omeprazole
in [Heart Medication]
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From: gobionessert on 11 Nov 2007 21:37 I am currently trying gaviscon, will try it in liquid and tablet form for the next two weeks. Doesnt seem to be working too well Anyway, regarding omeprazole or similar drugs one of my co-workers had GERD and she said she didnt want to go on the medication at the time because she said once on it you are always on it. Is this true? Or should I try it out to find out once and for all if I really have GERD by seeing if it works. Some other posters have mention these drugs being toxic if taken for a long time. And lastly, should you be tested for the h pyroli bacteria or something in your gut before taking it?
From: trigonometry1972 on 12 Nov 2007 13:31 On Nov 11, 6:37 pm, "gobioness...(a)yahoo.com" <gobioness...(a)yahoo.com> wrote: > I am currently trying gaviscon, will try it in liquid and tablet form > for the next two weeks. Doesnt seem to be working too well > > Anyway, regarding omeprazole or similar drugs one of my co-workers had > GERD and she said she didnt want to go on the medication at the time > because she said once on it you are always on it. Is this true? Or > should I try it out to find out once and for all if I really have GERD > by seeing if it works. Some other posters have mention these drugs > being toxic if taken for a long time. > > And lastly, should you be tested for the h pyroli bacteria or > something in your gut before taking it? It is possible to get off of the PPI meds. It is true though there is some rebound stomach acidity that lasts for at least several days due to the build up of gastrin. Gastrin is the horrnone that among other things tell the glands in the stomach to make acid. The hormone comes is a number of forms some of which are longer acting than others. In my case, I was told by the NP I would needed to think of PPI meds like a diabetic thinks of metaformin. I was to quit PPI meds twice first Aciphex (rabeprazole) and then later omeprazole due adverse effects. The last time the adverse effects were very strong such that I became absolutely determined to try ANYTHING else first. I'vebeen able to stay in remission for 3 years and 5 months without the PPI meds using a mixture of conservative actions (sleeping on a 12 to 18 inch inclined bed and the use of an alternative medicine idea which claims much of the dyspepsia seen in the population is the lack of enough stomach acidity. Understand this is NOT true for everyone and some folks have a number of disease processes going on at the same time. Due to my taking generous doses (larger that what the bottle says) of betaine HCL I've been able to prevent the day time dyspepsia. In the past prior to this action, meals often just set in the stomach and caused belching of somewhat acid stomach contents. I also still avoid chocolate, Cola drinks, coffee and china tea as these make the LES relax. Anyway with the digestive supplement, I do really well. But I still must sleep on an incline. I DO NOT believe taking the digestive supplement without the inclined sleeping position is wise in the context of a relaxation prone LES. Further, I do some other things that MAY help. I use melatonin and taurine which may help with inflammation. And I've used a GABA supplement off and on which may help the LES to stay closed though I not sure of this. These are out of the alternative medicine playbook and are even a little on the edge from that point of view. A standard MD will only sneer at some of these ideas but they work for me. Yes you should be tested for Helicobactor pylori as the use of PPI meds in the context of said infection will speed gastric atropy as I recall. I believe this in the conventional medical journals and isn't an alternative medical idea. Though it is likely some alt med Docs are aware of this problem with the PPI meds.
From: trigonometry1972 on 12 Nov 2007 21:09 Here is randomised controlled trial that supports the value of being checked for Helicobacter pylor in the context of GERD. I've included the link and the abstract. Be sure to read the conclusion of the abstract to get the point. Full article is available without charge at this link. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=14684569 : Gut. 2004 Jan;53(1):12-20. Comment in: Gut. 2004 Jan;53(1):5-7. Gut. 2004 Jun;53(6):912. Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial. Kuipers EJ, Nelis GF, Klinkenberg-Knol EC, Snel P, Goldfain D, Kolkman JJ, Festen HP, Dent J, Zeitoun P, Havu N, Lamm M, Walan A. Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands. e.j.kuipers(a)erasmusmc.nl BACKGROUND: Helicobacter pylori gastritis may progress to glandular atrophy and intestinal metaplasia, conditions that predispose to gastric cancer. Profound suppression of gastric acid is associated with increased severity of H pylori gastritis. This prospective randomised study aimed to investigate whether H pylori eradication can influence gastritis and its sequelae during long term omeprazole therapy for gastro-oesophageal reflux disease (GORD). METHODS: A total of 231 H pylori positive GORD patients who had been treated for > or =12 months with omeprazole maintenance therapy (OM) were randomised to either continuation of OM (OM only; n = 120) or OM plus a one week course of omeprazole, amoxycillin, and clarithromycin (OM triple; n = 111). Endoscopy with standardised biopsy sampling as well as symptom evaluation were performed at baseline and after one and two years. Gastritis was assessed according to the Sydney classification system for activity, inflammation, atrophy, intestinal metaplasia, and H pylori density. RESULTS: Corpus gastritis activity at entry was moderate or severe in 50% and 55% of the OM only and OM triple groups, respectively. In the OM triple group, H pylori was eradicated in 90 (88%) patients, and activity and inflammation decreased substantially in both the antrum and corpus (p<0.001, baseline v two years). Atrophic gastritis also improved in the corpus (p<0.001) but not in the antrum. In the 83 OM only patients with continuing infection, there was no change in antral and corpus gastritis activity or atrophy, but inflammation increased (p<0.01). H pylori eradication did not alter the dose of omeprazole required, or reflux symptoms. CONCLUSIONS: Most H pylori positive GORD patients have a corpus predominant pangastritis during omeprazole maintenance therapy. Eradication of H pylori eliminates gastric mucosal inflammation and induces regression of corpus glandular atrophy. H pylori eradication did not worsen reflux disease or lead to a need for increased omeprazole maintenance dose. We therefore recommend eradication of H pylori in GORD patients receiving long term acid suppression. PMID: 14684569 [PubMed - indexed for MEDLINE] Related Links Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy. [Gut. 2000] PMID:10764703 Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression. [Helicobacter. 2000] PMID:11179985 Effect of Helicobacter pylori eradication on treatment of gastro-oesophageal reflux disease: a double blind, placebo controlled, randomised trial. [Gut. 2004] PMID:14724146 Changes in Helicobacter pylori-induced gastritis in the antrum and corpus during long-term acid-suppressive treatment in Japan. [Aliment Pharmacol Ther. 2000] PMID:11012481 Increase of Helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for long-term safety. [Am J Gastroenterol. 1995] PMID:7661157
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