glyburide
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From: Jason on 1 Dec 2005 15:43 I control my sugars well with Metformin and Glyburide. Without Glyburide and using only Metformin (on an ultra low-carb diet), my sugars run 115=120. But all of this research about Glyburide causing cardiac events and burning out my beta cells has me concerned. What could be another alternative to Glyburide? Thanks
From: Jenny on 1 Dec 2005 16:28 Jason wrote: > I control my sugars well with Metformin and Glyburide. Without Glyburide > and using only Metformin (on an ultra low-carb diet), my sugars run 115=120. > But all of this research about Glyburide causing cardiac events and burning > out my beta cells has me concerned. What could be another alternative to > Glyburide? Thanks > > Tolbutamide was the drug that the article I posted said was selective in targeting the beta cells. It's an older drug and cheaper then amaryl, but I don't know anything else about it. It's still a sulf drug. There are also the newer drugs like Prandin which supposedly only stimulate the beta cells in response to carbs. They are shorter acting and might be kinder to the body. I don't really know about that. Beyond that, there are the glitazone drugs: Avandia and Actos, which are supposed to reduce insulin resistance. Some people find them extremely helpful along with metformin. Others, like myself, find that they cause unacceptable water retention. If you can tolerate them, there's some evidence that they may have a protective effect on beta cells, but they are too new for it to be entirely clear how they work. The negative with them is that they can cause weight gain, however if you use them with a low carb diet, that may not be a problem.
From: W. Baker on 1 Dec 2005 16:54 Jason <johndoe(a)hotmail.com> wrote: : I control my sugars well with Metformin and Glyburide. Without Glyburide : and using only Metformin (on an ultra low-carb diet), my sugars run 115=120. : But all of this research about Glyburide causing cardiac events and burning : out my beta cells has me concerned. What could be another alternative to : Glyburide? Thanks There are two shorter acting bta cell pushers, Prandin and Starliz, taken right before meals that might work while putting less of a lead o the pancres. They also don't give he appetiie increse tht tthe adding of insulin form you pancreas all day can cause. There are other modalities, like using Actos or Avandia, either of which work to reduce insulin resistnce. Wendy
From: old al on 1 Dec 2005 18:18 Jason wrote: > I control my sugars well with Metformin and Glyburide. Without Glyburide > and using only Metformin (on an ultra low-carb diet), my sugars run 115=120. > But all of this research about Glyburide causing cardiac events and burning > out my beta cells has me concerned. What could be another alternative to > Glyburide? Thanks See Jenny's post for remarks on alternate beta stimulators (the meglitinides Prandin and Starlix ). If you want to avoid the beta stimulators, one sequence I have seen: Start with metformin up to 2500 mg/day Add Actos or Avandia if needed Add insulin injections if needed However, nowadays, there is Byetta (very expensive, injected before meals) which can be slipped in before the insulin. That sequence maximizes the amount of protection you can offer your tired beta cells. Regards Old Al
From: Jefferson on 1 Dec 2005 21:12
old al wrote: > Add insulin injections if needed > > However, nowadays, there is Byetta (very expensive, injected > before meals) which can be slipped in before the insulin. The only person I know that uses Byetta came off of insulin after Byetta therapy started. She happens to be a diabetic educator. Frank |