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From: rosbif on 22 Jul 2008 13:23
On Tue, 22 Jul 2008 17:26:42 +0100, MikeHi(a)anon.com wrote:

>I'm a target candidate. I'll report back. I'll either be on it
>or my onco will be walking with a permanent limp.

Kindly provide address of railings if you need me to chain myself up
in support of your demands for this. If there's any self-hurling
under the Queen's horses......I might have to leave that to you....
From: tarhoosier on 22 Jul 2008 17:25
On Jul 22, 1:23 pm, rosbif wrote:
> On Tue, 22 Jul 2008 17:26:42 +0100, Mik...(a)anon.com wrote:
> >I'm a target candidate. I'll report back. I'll either be on it
> >or my onco will be walking with a permanent limp.
>
> Kindly provide address of railings if you need me to chain myself up
> in support of your demands for this. If there's any self-hurling
> under the Queen's horses......I might have to leave that to you....

Not really old news. The appearance and testing of AA and its promise
has been known for some time. The advancing to Phase III, the use of
chemo refractory patients as the first trial group, and the release of
the full Phase II results with patient anecdotes, and predictions(!)
from such an august voice as Dr de Bono is newly news.
From: kh on 22 Jul 2008 20:12
On Jul 22, 12:26 pm, Mik...(a)anon.com wrote:

> And kh, after all you've been through, we don't want you to go of
> sunstroke just when the cavalry's appearing. Here's the best and
> simplest and surest therapy you've ever been offered. You've got a
> bald head. Wear a sun hat. Works wonders.

I must be a mad-dog to go out into the sun, only one type does that.

I was out there on purpose, trying to get the sides tanned to match
the top. When my hair fell out, I discovered pale sides and a tan
top. These are called the "White-sidewalls" look. I was developing
the "Friar Tuck" look with heavy hair on the side and bald on the
tippy-top.

This abiraterone is great news but I'm not getting my hopes up....
Who am I kidding. This is the news I've been waiting and watching
for. My hopes are up. Wa-hooo! You all read the articles and patient
experiences!

A couple pills once a day.

-kh compared to the half dozen I take now.
From: J on 23 Jul 2008 03:11
tarhoosier(a)carolina.rr.com wrote:

> On Jul 22, 1:23 pm, rosbif wrote:
> > On Tue, 22 Jul 2008 17:26:42 +0100, Mik...(a)anon.com wrote:
> > >I'm a target candidate. I'll report back. I'll either be on it
> > >or my onco will be walking with a permanent limp.
> >
> > Kindly provide address of railings if you need me to chain myself up
> > in support of your demands for this. If there's any self-hurling
> > under the Queen's horses......I might have to leave that to you....
>
> Not really old news. The appearance and testing of AA and its promise
> has been known for some time. The advancing to Phase III, the use of
> chemo refractory patients as the first trial group, and the release of
> the full Phase II results with patient anecdotes, and predictions(!)
>

The Phase III trial is in 37 locations
http://clinicaltrials.gov/ct2/show/NCT00638690
and it's not proven helpful for bone mets, so may help a small subset who
have other mets, but not brain mets.

" A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of
Abiraterone Acetate (CB7630) Plus Prednisone in Patients With Metastatic
Castration-Resistant Prostate Cancer Who Have Failed Docetaxel-Based
Chemotherapy
Estimated Enrollment: 1158
Study Start Date: April 2008
Estimated Study Completion Date: June 2011
Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator,
Outcomes Assessor), Placebo Control, Parallel Assignment, Safety/Efficacy
Study
Primary Outcome Measures:
* Overall Survival [ Time Frame: During the Study ] [ Designated as
safety issue: No ]
Estimated Primary Completion Date: June 2011 (Final data collection
date for primary outcome measure)
37 Study Locations

So it looks like it could be palliative, after Docetaxel, and before bone
or brain mets show up.
J


From: MikeHi on 23 Jul 2008 07:58
What is maybe interesting is the speed of development. I first
highlighted abiraterone (we better get used to calling it AA) from
this Institute of Center Research site March 10.

http://www.icr.ac.uk/research/new_research_highlights/research_highlights/8727.shtml
or
http://tiny.cc/WRD7M
Dr de Bono then concluded the report: "Further evaluation of
abiraterone, with American collaborators, is now ongoing with a view
to pursuing, in the near future, the studies required for regulatory
approval of the drug so that it can ultimately be used routinely in
hospitals", concludes Dr de Bono.

So in four months it's gone from 'what might be' to what is now
happening. I've already mentioned that in the latest report Dr de Bono
forsees three years for likely hospital ready.

Here's a guess for kh and others. Available in two years. If in
another year the studies continue to confirm the findings - these
trials too will be raced forward. Because if it does what it says on
the box, the clamour to get it out and save lives will be quite
something -and in the case of extreme sufferers, what's to lose?
If the kh's of this world say, 'Hey! I'll take it -and S/E's are down
to me' - who would stop them?

(Note for ng purists. A'guess' ranks even lower than 'anecdotal' by
way of evidence.)

>J writes: So it looks like it could be palliative, after Docetaxel,
> and before bone or brain mets show up.

J, it's right the clinical research said Docetaxel had to have been
used and failed on trialists. That's the fatal, uncurable, type the
research has focussed on.
But I do not think that is *only* when it is going to work - if this
phrase from the ICR research means anything:

'Abiraterone blocks the generation of these hormones in the
testes and elsewhere in the body, including the generation of hormones
in the cancer itself. '

So it should surely block the cancer when it is present, at whatever
stage. Even if the Pca becomes high risk metastatic before the use of
any HT or chemos (like me). But for those who have become hormone
resistant (and we know that then *new* pathways for the cancer are
opened up) it is the BIG white hope.

>Rosbif wrote:
>I got the impression it was hoped that this would be a relatively
>low toxicity replacement for chemo, rather than an addition to it.
That's certainly how I read the ICR report. The AA pill. Few side
effects.

(Chain yourself to the railings? Nahh. You gotta be a woman and do
that and get noticed. ..I'd only have to come and feed you..)

My very best wishes and big hopes for all.

MikeHi
"Exponential lightspeed". Def: The discovery of the cure for Pca at a
speed which defies Einstein.





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