Zoladex (Goselerin) How long does it work?
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From: Steve Kramer on 1 Oct 2005 07:10 I'm glad to hear from you. I mean I'm really glad to hear. I'm on Lupon for 2+ years with half your original PSA and 'only' a 7 Gleason. Of course, I was 20 years younger which works against me, I guess. But, I still watch your posts with great interest. -- PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum "Di ck Winters" <wintersrm(a)webtv.net> wrote in message news:1128008280.907091.16170(a)o13g2000cwo.googlegroups.com... > I have been on Lupron, starting 3 years after my prostate was removed, > for five and a half years now. I was also on Casodex for 3 of those > years. My PSA has remained at <0.1. I always am concerned about each > quarterly appointment with my doctor, but so far so good. I see him > again in October. >
From: Steve Kramer on 1 Oct 2005 07:15 I concur. I don't know your age or stats (other than a 28 PSA), but I was surprised when you got HT before RT. RRP can cure. RT can still cure. HT almost never cures. -- PSA 16 10/17/2000 @ 46 Biopsy 11/01/2000 G7 (3+4), T2c RRP 12/15/2000 G7 (3+4), T3cN0M0 Neg margins PSA .1 .1 .1 .27 .37 .75 EBRT 05-07/2002 @ 47 PSA .34 .22 .15 .21 .32 Lupron 07/03 (1 mo) 8/03 (4 mo), 12/03, 4/04, 09/04, 01/05 PSA .07 .05 .06 .05 non Illegitimi carborundum "Justin Case" <krblmb(a)brainspring.com> wrote in message news:ekd%e.1442$4h2.634(a)newsread3.news.pas.earthlink.net... > > "Alan Meyer" <ameyer2(a)yahoo.com> wrote in message > news:1128036860.652107.141390(a)z14g2000cwz.googlegroups.com... > : Gareth Jefferson wrote: > : > : > I was put on Zoladex a year ago, stopped last December, > : > then told to resume a week ago. > : > > : > Does anyone know how long this ablates testosterone? > : > > : > I thought about 18 months was it. > : > : Gareth, > : > : I'm not an expert, but here's the theory as I understand it. > : > : Lupron, Zoladex, and other LHRH agonists suppress the > : production of testosterone for as long as you > : take them. > > <Remainder snipped> > > Your explanation, Alan, is certainly more complete than anything I can offer > but my doctor said that, in layman's terms, Lupron, the one hormone I was > injected with twice, essentially "puts the cancer cells to sleep, makes them > dormant, for a while but does nothing to kill or destroy them." It was > explained to me that most men achieve benefit from hormone injections, if > they benefit at all, for little more than two years, at which time the > cancer cells, again speaking metaphorically, reawaken. > > After two such injections of Lupron and dubious PSA results following it was > recommended that radiation should be my next option. Radiation has its > undesirable consequences as well but in my case my PSA checks have been > undetectable for nearly four years. > > Ken Bland > >
From: Gareth Jefferson on 2 Oct 2005 08:06 Thanks for all the encouraging response. The on-again-off-again story of my Zoladex (more or less = Luperon) is this. Somewhat over a year ago my MRI scan showed a dark lump in my right pelvic lymph node that, according to the radiologist's report, was "probably metastasis". So my oncologist put me on Zoladex as "only palliative care is available to you now". Later my urologist thought the "metastasis" was more likely calcification of the lymph node; I was subsequently offered a place on a trial at University College Hospital, London for the HIFU modality (at present still fairly new in the UK), but was told that to be eligible for the trial I would have to be off Zoladex, Lupron and similar LHRH agonists for a minimum of six months. So I stopped last December. A couple of weeks ago the hospital contacted me to say I should go back on Zoladex (read: "You're not on the trial any more") University College Hospital London (aka The Middlesex Hospital) may, in the fullness of time, acquire a new HIFU machine, but how long this could take, and how soon I could be expected to be operated on is unknown, and very likely unknowable. So I am considering having the procedure done in France, or possibly Japan. The British National Health Service certainly spreads round the misery very equably between those who have and those who have not. America is so much more Biblical: "Unto every one that hath shall be given, and he shall have abundance: but but from him that hath not shall be taken away even that which he hath. Regards, -- Gareth. On 1/10/05 12:10 pm, in article I8u%e.61386$vJ4.49886(a)tornado.ohiordc.rr.com, "Steve Kramer" <skramer(a)cinci.rr.com> wrote: > I'm glad to hear from you. I mean I'm really glad to hear. I'm on Lupon > for 2+ years with half your original PSA and 'only' a 7 Gleason. Of course, > I was 20 years younger which works against me, I guess. But, I still watch > your posts with great interest.
From: I. P. Freely on 2 Oct 2005 13:57 "Gareth Jefferson" > > America is so much > more Biblical: "Unto every one that hath shall be given, and he shall have > abundance: but but from him that hath not shall be taken away even that > which he hath. Someone's been reading and watching too much anti-American propaganda. Get back to us when you learn some, you know . . . FACTS. Example: Everyone has access to medical care . . . and it ain't the poor who pay for most of it. I.P.
From: Alan Meyer on 2 Oct 2005 21:10
"Steve Kramer" <skramer(a)cinci.rr.com> wrote in message news:3du%e.61412$vJ4.39847(a)tornado.ohiordc.rr.com... >I concur. I don't know your age or stats (other than a 28 PSA), but I was > surprised when you got HT before RT. RRP can cure. RT can still cure. HT > almost never cures. Agreed. Did Gareth's doctors think his cancer was inoperable and inaccessible to x-rays? If so, HT would be the recommended treatment. If not, unless he was already advanced in years or seriously ill with other conditions, you'd think they'd have sent him for RP or RT. Alan |