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From: oralhealth on 11 Aug 2008 18:49
Is it because it is not caused by plaque?

David DiBenedetto, DMD "Insider's guide to gum disease, orthodontics
and dentistry. What is not taught in dental school."
From: tenthmed on 11 Aug 2008 20:03
Simply put, periodontopathic organisms + altered host immune response =
periodontal disease(s)

Do you know something "new"?
From: oralhealth on 11 Aug 2008 20:45
On Aug 11, 8:03 pm, tenthmed <tenth...(a)aol.com> wrote:
> Simply put, periodontopathic organisms + altered host immune response =
> periodontal disease(s)
>
> Do you know something "new"?

It is not that simple. First:

(1)What is an altered host immune response? (2) Who gets altered
host immune response?

(3)What other diseases follow this model? (4) How do you know when
one has an altered immune response? (5)How do I give this disease to
others?

(6)Does this mean I cure the disease by altering the host immune
response? (7) Does this mean I cure the disease by changing the
periodontopathetic organsims?

(8) It would seem that it should be an easy disease to cure if we
eliminated either the organisms or changed the host response?

(9) then why can't we change the organisms effortlessly with
antibiotics?

and (10) Why should we do surgery on someone with an altered immune
response?



From: Mark & Steven Bornfeld on 12 Aug 2008 11:16
oralhealth(a)comcast.net wrote:
> On Aug 11, 8:03 pm, tenthmed <tenth...(a)aol.com> wrote:
>> Simply put, periodontopathic organisms + altered host immune response =
>> periodontal disease(s)
>>
>> Do you know something "new"?
>
> It is not that simple. First:
>
> (1)What is an altered host immune response? (2) Who gets altered
> host immune response?


Good question. Back in the days when I read (ahem) more of the
literature there was a paper by Socransky in J. perio. about subtle
differences in chemotaxis of leukocytes of patients with juvenile
periodontitis. As this was over 30 years ago, I'm sure more of the
genetic basis for this, as well as garden variety perio disease, as well
as details on the phenotypic expression have been clarified since. IIRC
they presented evidence that this leukocytic defect was inherited as an
autosomal dominant.
I'm out of my depth discussing immunology generally, and certainly the
immunology of periodontal disease. But that certainly doesn't mean that
there aren't others out there that can't answer your questions in
greater depth.

Steve


>
> (3)What other diseases follow this model? (4) How do you know when
> one has an altered immune response? (5)How do I give this disease to
> others?
>
> (6)Does this mean I cure the disease by altering the host immune
> response? (7) Does this mean I cure the disease by changing the
> periodontopathetic organsims?
>
> (8) It would seem that it should be an easy disease to cure if we
> eliminated either the organisms or changed the host response?
>
> (9) then why can't we change the organisms effortlessly with
> antibiotics?
>
> and (10) Why should we do surgery on someone with an altered immune
> response?
>
>
>


--
Mark & Steven Bornfeld DDS
http://www.dentaltwins.com
Brooklyn, NY
718-258-5001
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