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From: Allan WW on 24 Mar 2006 06:26

Why do antidepressants (SSRIs in particular) take so long to work?

Thank you,

Allan
From: Cassandra on 24 Mar 2006 19:39
I don't think anyone really knows why, actually. One theory, though,
is that that's how long it takes new neurons to develop, or new
receptors to be created.

Newer studies have shown that antidepressant medication therapy results
in increased volume in the hippocampus, which would tend to support
that theory.

But the bad news is, it still takes SSRIs a while to kick in...

From: Nom dePlume on 24 Mar 2006 19:55
"Cassandra" <babbler39(a)excite.com> wrote in message
news:1143247175.957445.124550(a)t31g2000cwb.googlegroups.com...
>I don't think anyone really knows why, actually. One theory, though,
> is that that's how long it takes new neurons to develop, or new
> receptors to be created.
>
> Newer studies have shown that antidepressant medication therapy
> results
> in increased volume in the hippocampus, which would tend to support
> that theory.
>
> But the bad news is, it still takes SSRIs a while to kick in...

What Cassandra said--there is evidence that serotonergic
antidepressants stimulate the growth of serotonin receptors, a process
that takes about two weeks.

Antidepressant effects that result from increases in norepinephrine or
dopamine concentration can be much quicker.

--
Nom dePlume, Ph.D.
Why, yes, in fact, I am a rocket scientist.

Guide to Medications for Mental Illness:
http://www.geocities.com/nomdeplume1000/

=====


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