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From: MartinS on 1 Feb 2010 16:07
Helen Howes <helenhowestextiles(a)googlemail.com> wrote:

> It seems that Metformin is what I call a "bucket' drug. Until your
> body is almost saturated it has little therapeutic effect; then you
> add a little each day to make up for the little you have used; leaving
> most of the bucketful in your system. Some drugs have a very long
> half-life like this, others disappear like magic (try me if I forget
> my steroids for an hour or two after they should have been taken...)
>
> Anyway, after much experimentation I decided that the time of day for
> taking Metformin was almost irrelevant to the result; as it mostly
> affects the liver and not the digestive process there is a
> considerable lag. You can't offset a big meal with an extra tablet
> either. I take 1000mg morning and evening, as it means I don't have to
> carry tablet around with me..
>
> YMMV as we say..
>
> Keep on trucking
>
> Helen Howes

I take 500mg Metformin at breakfast time and 1000mg at bedtime with my
other night-time pills. I've never had any gastric reaction, and it's
easier to take all my bedtime pills together than to remember to take the
Metformin with dinner. I also take 30mg Diamicron/Gliclazide SR in the
morning.

--
Martin S. (Canada)
From: Urlay Nook on 1 Feb 2010 16:32
I take a 500mg after breakfast and another 500mg after tea.
John (UK)

"MartinS" <me(a)my.place> wrote in message
news:ooH9n.40721$mT7.14786(a)newsfe05.iad...
> Helen Howes <helenhowestextiles(a)googlemail.com> wrote:
>
>> It seems that Metformin is what I call a "bucket' drug. Until your
>> body is almost saturated it has little therapeutic effect; then you
>> add a little each day to make up for the little you have used; leaving
>> most of the bucketful in your system. Some drugs have a very long
>> half-life like this, others disappear like magic (try me if I forget
>> my steroids for an hour or two after they should have been taken...)
>>
>> Anyway, after much experimentation I decided that the time of day for
>> taking Metformin was almost irrelevant to the result; as it mostly
>> affects the liver and not the digestive process there is a
>> considerable lag. You can't offset a big meal with an extra tablet
>> either. I take 1000mg morning and evening, as it means I don't have to
>> carry tablet around with me..
>>
>> YMMV as we say..
>>
>> Keep on trucking
>>
>> Helen Howes
>
> I take 500mg Metformin at breakfast time and 1000mg at bedtime with my
> other night-time pills. I've never had any gastric reaction, and it's
> easier to take all my bedtime pills together than to remember to take the
> Metformin with dinner. I also take 30mg Diamicron/Gliclazide SR in the
> morning.
>
> --
> Martin S. (Canada)

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