Whats Next?
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From: welshboy on 2 Mar 2006 11:41 Its a while since I posted this question and am wondering with the developments in the pharmaceutical world what is next in the line against depression. Will there be any seretonin meds that work better than SSRI's on seretonin? Meds for other neurotransmitters? Other ways of meds targeting the brain? Any invasive developments such as ECT, VNS? Probably neieve question and sub questions but interested. D
From: Nom dePlume on 2 Mar 2006 22:30 "welshboy" <dylan(a)nospam.com> wrote in message news:f007a08eebeb9307609e1742fbbfae81(a)localhost.talkaboutsupport.com... > Its a while since I posted this question and am wondering with the > developments in the pharmaceutical world what is next in the line against > depression. > Will there be any seretonin meds that work better than SSRI's on > seretonin? > Meds for other neurotransmitters? > Other ways of meds targeting the brain? > Any invasive developments such as ECT, VNS? > > Probably neieve question and sub questions but interested. No, not naive. I think serotonin, norepinephrine, and dopamine have been worked over well enough by now that we're not going to see much new in drugs that affect them. New avenues might include drugs that affect glutamate, cortisol, or inositol. For non-drug therapy, I think deep brain stimulation (DBS) and deep transcranial magnetic stimulation (deep TMS) are interesting. I don't know of anything coming out soon, though. -- Nom dePlume, Ph.D. Why, yes, in fact, I am a rocket scientist. Guide to Medications for Mental Illness: http://www.geocities.com/nomdeplume1000/ =====
From: radiohead on 2 Mar 2006 23:09 ive read about opioids being tested as drugs used for treatment resistent depression. buperenorphine was the main one ive read about. its a better choice then the more traditional opiates because the tolerance only goes up so high do to its antagonist proporties. i remember reading somewhere that low doses of kappa agonist opioids taken over a peroid of time act as antidepressants as well. they induce dysphoria instead of euphoria in high doses. i dont know if any of this will ever become standard medical practice seeing as how we are currently in the grips of a anti narcotic hysteria.
From: welshboy on 3 Mar 2006 03:13 so would a drug made out of opiates say, supercede the qualities of SSRI's for depression. i.e. I am on SSRI and Laictal, OK for about 3 week run and then terrible for 3-7 days. I know I have seretonin issues. Would opiate meds kind of supercede and kind of takeover from where the SSRI left off. Or would it mask the ssri action totally. Would it be like taking paracetamol for pain which works a bit and then taking methadone which numbs you completely. wouldnt opiod meds put you in a daze?
From: Larry Hoover on 3 Mar 2006 09:25
"welshboy" <dylan(a)nospam.com> wrote in message news:f007a08eebeb9307609e1742fbbfae81(a)localhost.talkaboutsupport.com... > Its a while since I posted this question and am wondering with the > developments in the pharmaceutical world what is next in the line against > depression. > Will there be any seretonin meds that work better than SSRI's on > seretonin? > Meds for other neurotransmitters? > Other ways of meds targeting the brain? > Any invasive developments such as ECT, VNS? > > Probably neieve question and sub questions but interested. > > D I think serotonin has been good and thoroughly flogged as the depressogenic neurotransmitter being blamed. Look for novel mechanisms to come to the fore, soon. Cannabinoid receptor research has been making some great strides (in countries where the War on Drugs mentality has not paralyzed thinking). One other novel approach that just won't come to the front of my cerebral cortex. I'm going to have to see if I can find this link that I know of......it lists all the psych research that has gotten good results at Phase 2, or more fully developed than Phase 2. There are hundreds of research projects underway. Lar |