Prev: Launching programs from EagleSoft (i.e. bridging)
Next: Do I Need An Implant?
From: oralhealth on 19 Aug 2008 20:18

(1) Isolate the organism from the infected

(2) reproduce the organism in a culture

(3) inoculate a susceptible host

(4)re-isolate the organism from the diseased host


Why is it needed? To prove organisms cause a specific disease.

Then why doesn't periodontal disease follow Koch's postulates?





From: Steven Bornfeld on 19 Aug 2008 23:16
oralhealth(a)comcast.net wrote:
> (1) Isolate the organism from the infected
>
> (2) reproduce the organism in a culture
>
> (3) inoculate a susceptible host
>
> (4)re-isolate the organism from the diseased host
>
>
> Why is it needed? To prove organisms cause a specific disease.
>
> Then why doesn't periodontal disease follow Koch's postulates?
>
>
>
>
>
http://cat.inist.fr/?aModele=afficheN&cpsidt=16784225

Steve
From: tenthmed on 20 Aug 2008 17:43
More correctly what "are" instead of "is" for a plural direct object in
the English language.
From: Mark & Steven Bornfeld on 20 Aug 2008 18:07
tenthmed wrote:
> More correctly what "are" instead of "is" for a plural direct object in
> the English language.


You are forgiven, my son. In Brooklyn, correct usage dictates what "be".

Steve

--
Mark & Steven Bornfeld DDS
http://www.dentaltwins.com
Brooklyn, NY
718-258-5001
From: oralhealth on 20 Aug 2008 19:23
On Aug 19, 11:16 pm, Steven Bornfeld <dentaltwinm...(a)earthlink.net>
wrote:
> oralhea...(a)comcast.net wrote:
> > (1) Isolate the organism from the infected
>
> > (2) reproduce the organism in a culture
>
> > (3) inoculate a susceptible host
>
> > (4)re-isolate the organism from the diseased host
>
> > Why is it needed? To prove organisms cause a specific disease.
>
> > Then why doesn't periodontal disease follow Koch's postulates?
>
> http://cat.inist.fr/?aModele=afficheN&cpsidt=16784225
>
> Steve



Dentists forget the difference between Caries and P.D. Caries is
easy to understand, P.D. is not.

From the abstract, and from the first line: "The Pathogenesis of
periodontal disease is not well known." I didn't say it, the first
sentence of the abstract did.

Bone loss can only occur from osteoclasts!!! Osteoclasts cause bone
loss. Period.

Cystokines, chemotactic factors influence the osteoclasts by way of
inflammatory cells.

This study says that A.A. inoculated in mice resulted in inflammation
and different mediators were present over time.

Obvious questions about the study?

(1) were there controls?
(2) What kind of mice did they use? What gene type? What is the
lifespan of these mice?
(3) Were they prebubescence mice?
(4) Why weren't dogs selected vs mice? How good is the mouse model?
In cancer it is not that good.
(5) Explain the inoculation process? Did they inject the gingiva? In
man, no organism are found in the gum tissue, only in the sulcus.
(6) Did all sites breakdown?
(7) How many organisms were introduced?

And the last sentence is interesting, "our results suggest that
expression of cytokines and chemokines can the drive the selective
recruitment of leukocyte subsets to periodontal tissues, which could
determine the stable or progessive nature of the lesion."

Also, the periodontal textbooks say that bone loss can occur without
any inflammation. Some of the most destructive P.D. lesions occur
without any inflammation.













 |  Next  |  Last
Pages: 1 2 3 4
Prev: Launching programs from EagleSoft (i.e. bridging)
Next: Do I Need An Implant?