From: Mark Probert on
On Feb 24, 12:18 am, Mike <M...(a)localhost.localdomain> wrote:
> Mark Probert wrote:
> > In this post:
>
> > ------Begin quote------
>
> > Message from discussion Why Vaccines May Be Bad
>
> > View parsed - Show only message text
>
> > Path: g2news2.google.com!postnews.google.com!
> > v25g2000yqk.googlegroups.com!not-for-mail
> > From: Jan Drew <jdrew63...(a)aol.com>
> > Newsgroups:
> > sci.med,sci.med.nursing,sci.med.pharmacy,misc.health.alternative,misc.kids.­health
> > Subject: Re: Why Vaccines May Be Bad
> > Date: Sun, 21 Feb 2010 13:47:24 -0800 (PST)
> > Organization:http://groups.google.com
> > Lines: 8
> > Message-ID: <c4bf5652-
> > ccf4-4016-9801-1cf4730ab...(a)v25g2000yqk.googlegroups.com>
> > References: <242544b1-bafb-4abd-9be8-
> > e8752df05...(a)x22g2000yqx.googlegroups.com>
> >    <d6c8c599-bcd3-45bb-a2ca-cd208c0fb...(a)z1g2000prc.googlegroups.com>
> >    <ddf1c82b-77a5-4f3f-b0b4-edd4239ae...(a)15g2000yqi.googlegroups.com>
> >    <WoWdnVH3NPs25RzWnZ2dnUVZ_u5i4...(a)giganews.com>
> > NNTP-Posting-Host: 205.188.116.65
> > Mime-Version: 1.0
> > Content-Type: text/plain; charset=UTF-8
> > Content-Transfer-Encoding: quoted-printable
> > X-Trace: posting.google.com 1266788844 891 127.0.0.1 (21 Feb 2010
> > 21:47:24 GMT)
> > X-Complaints-To: groups-ab...(a)google.com
> > NNTP-Posting-Date: Sun, 21 Feb 2010 21:47:24 +0000 (UTC)
> > Complaints-To: groups-ab...(a)google.com
> > Injection-Info: v25g2000yqk.googlegroups.com; posting-
> > host=205.188.116.65;
> >    posting-account=40HPKQoAAABwSFWWdvGlBjB7F-dFMkyi
> > User-Agent: G2/1.0
> > X-HTTP-Via: HTTP/1.1 (Velocity/3.1.1.5 [uScMs f p eN:t cCMp s ]), HTTP/
> > 1.1
> >    spider-dtc-tf08.proxy.aol.com[CDBC70A8] (Prism/1.2.1), HTTP/1.1
> >    cache-dtc-ab01.proxy.aol.com[CDBC7441] (Traffic-Server/6.1.5 [uScM])
> > X-HTTP-UserAgent: Mozilla/4.0 (compatible; MSIE 7.0; AOL 9.0; Windows
> > NT 6.1;
> >    WOW64; Trident/4.0; SLCC2; .NET CLR 2.0.50727; .NET CLR
> > 3.5.30729; .NET CLR
> >    3.0.30729; Media Center PC 6.0),gzip(gfe),gzip(gfe)
>
> > On Feb 21, 1:17=EF=BF=BDpm, dr_jeff <u...(a)msu.edu> wrote:
> >  > Enough said.
>
> > More than enough since you are not a doctor, but continue to lie.
>
> > For a real M.D.  See:
>
> >http://www.millerfamilymedicine.com/
> >  -------End Quote_____
>
> > Jan endorses Dr. Miller.
>
> > I visited his website and can see that he is a hard working member of
> > the medical profession.
>
> > I also found links which resulted in these:
>
> > "With proper hygiene and proper precautions, in addition to numerous
> > vaccines and rapidly advancing medical technology, people are better
> > equipped than ever to avoid getting sick."
>
> > and
>
> >http://www.ecommunity.com/health/index.aspx?pageid=P02523
>
> <irrelevant stuff snipped>
>
> Mark, you are an idiot. You followed a link athttp://www.millerfamilymedicine.com/, found more links at
> the linked site and concluded that Dr.Miller endorsed whatever
> is there. He may, or he may not, there is no evidence.

Explain why he would link to information that he does not endorse. If
you had a website, would you link to the CDC? Of course you wouldn't.

> He does not "recommend immunizations". He has a generic link to a web
> site that has a different page (not referred by him) that recommends
> immunizations.

See above, logic challenged one.

> And why does he have this link? Given these links and that his web site
> and ecommunity.com have the same IP address 204.108.61.25 I would
> suggest there is a relationship. Most likely, he is a member of
> ecommunity.com (there is membership there), they may host his web site
> in exchange for links, this is common practice.

If he disagreed with the content, he could have separate hosting at
another provider. If he is doing it to "save money" then you are
calling him unethical. I do not see that.

> Here is a web site of another member:http://www.arborlanemed.com

Supports vaccinations.

> It looks very similar and has the same links.
> Needless to say, same IP address.-

Irrelevant.

From: Jan Drew on
On Feb 22, 9:55�am, Mark Probert <mark.prob...(a)gmail.com> wrote:
> In this post:
>
> ------Begin quote------
>
> Message from discussion Why Vaccines May Be Bad
>
> View parsed - Show only message text
>
> Path: g2news2.google.com!postnews.google.com!
> v25g2000yqk.googlegroups.com!not-for-mail
> From: Jan Drew <jdrew63...(a)aol.com>
> Newsgroups:
> sci.med,sci.med.nursing,sci.med.pharmacy,misc.health.alternative,misc.kids.�health
> Subject: Re: Why Vaccines May Be Bad
> Date: Sun, 21 Feb 2010 13:47:24 -0800 (PST)
> Organization:http://groups.google.com
> Lines: 8
> Message-ID: <c4bf5652-
> ccf4-4016-9801-1cf4730ab...(a)v25g2000yqk.googlegroups.com>
> References: <242544b1-bafb-4abd-9be8-
> e8752df05...(a)x22g2000yqx.googlegroups.com>
> � � � � <d6c8c599-bcd3-45bb-a2ca-cd208c0fb...(a)z1g2000prc.googlegroups.com>
> � � � � <ddf1c82b-77a5-4f3f-b0b4-edd4239ae...(a)15g2000yqi.googlegroups.com>
> � � � � <WoWdnVH3NPs25RzWnZ2dnUVZ_u5i4...(a)giganews.com>

Completely wrong, never have used giganews.com

> NNTP-Posting-Host: 205.188.116.65
> Mime-Version: 1.0
> Content-Type: text/plain; charset=UTF-8
> Content-Transfer-Encoding: quoted-printable
> X-Trace: posting.google.com 1266788844 891 127.0.0.1 (21 Feb 2010
> 21:47:24 GMT)
> X-Complaints-To: groups-abuse(a)google.com
> NNTP-Posting-Date: Sun, 21 Feb 2010 21:47:24 +0000 (UTC)
> Complaints-To: groups-abuse(a)google.com
> Injection-Info: v25g2000yqk.googlegroups.com; posting-
> host=205.188.116.65;
> � � � � posting-account=40HPKQoAAABwSFWWdvGlBjB7F-dFMkyi
> User-Agent: G2/1.0
> X-HTTP-Via: HTTP/1.1 (Velocity/3.1.1.5 [uScMs f p eN:t cCMp s ]), HTTP/
> 1.1
> � � � � spider-dtc-tf08.proxy.aol.com[CDBC70A8] (Prism/1.2.1), HTTP/1.1
> � � � � cache-dtc-ab01.proxy.aol.com[CDBC7441] (Traffic-Server/6.1.5 [uScM])
> X-HTTP-UserAgent: Mozilla/4.0 (compatible; MSIE 7.0; AOL 9.0; Windows
> NT 6.1;
> � � � � WOW64; Trident/4.0; SLCC2; .NET CLR 2.0.50727; .NET CLR
> 3.5.30729; .NET CLR
> � � � � 3.0.30729; Media Center PC 6.0),gzip(gfe),gzip(gfe)

Don't use any of that either, So much for Mark S Probert's
investigations skills.
>
> On Feb 21, 1:17=EF=BF=BDpm, dr_jeff <u...(a)msu.edu> wrote:
> �> Enough said.
>
> More than enough since you are not a doctor, but continue to lie.
>
> For a real M.D. �See:
>
> http://www.millerfamilymedicine.com/
> �-------End Quote_____
>
> Jan endorses Dr. Miller.
>
> I visited his website and can see that he is a hard working member of
> the medical profession.

You finally got something right.
>
> I also found links which resulted in these:
>
> "With proper hygiene and proper precautions, in addition to numerous
> vaccines and rapidly advancing medical technology, people are better
> equipped than ever to avoid getting sick."
>
> and
>
> http://www.ecommunity.com/health/index.aspx?pageid=P02523
>
> "The importance of immunizations:
> Immunization is key to preventing disease among the general
> population. Vaccines benefit both the people who receive them, and the
> vulnerable, unvaccinated people around them, because the infection can
> no longer spread. In addition, immunizations reduce the number of
> deaths and disability from infections, such as whooping cough and
> chickenpox.
>
> Although children receive the majority of the vaccinations, adults
> also need to stay up-to-date on certain vaccinations, including
> tetanus and diphtheria. In addition, those adults who have never had
> chickenpox or measles during childhood (nor the vaccines against these
> specific diseases) should consider being vaccinated. Childhood
> illnesses such as mumps, measles, and chickenpox can cause serious
> complications in adults.
>
> About guidelines for childhood immunizations:
> Many childhood diseases can now be prevented by following recommended
> guidelines for vaccinations:
>
> Meningococcal vaccine �- to protect against meningococcal disease..
> Hip B - to protect against hepatitis B.
> Polio vaccine �- to protect against polio.
> DTaP and Tdap - to protect against diphtheria, tetanus (lockjaw), and
> pertussis (whooping cough).
> Hib vaccine - to protect against Haemophilus influenzae type b (which
> causes spinal meningitis).
> MMR - to protect against measles, mumps and rubella (German measles).
> Pneumococcal vaccine �- to protect against pneumonia, infection in the
> blood, and meningitis.
> Varicella - to protect against chickenpox.
> RotaTeq� - to prevent rotavirus gastroenteritis in infants.
> Hep A - to prevent viral infection of the liver.
> HPV - to protect females from human papillomavirus, which is linked to
> cervical cancer. "
>
> and much more.
>
> Interestingly, Jan's "Real M.D." recommends the RotaTEQ vaccination
> invented by Dr. Paul Offit.
>
> I surely do wonder what Dr. Miller, who sounds like a really wonderful
> doctor, would say about Jan's incessent trashing of vaccinations and
> Dr. Offit?

Keep wondering. You might want to stop lying. I only post there are
no studies proving vaccination to be safe, You see I don't fall for
the lies of the CDC, FDA, or AMA, as they are *organized medicine*
And the fraud of all four including Offit, plus their vested interest,
From: Peter B on
"Jan Drew" <jdrew63929(a)aol.com> wrote in message
news:6f8fc9bb-6fb8-4da3-a64e-61711a904fff(a)k19g2000yqc.googlegroups.com...
On Feb 22, 9:55�am, Mark Probert <mark.prob...(a)gmail.com> wrote:
> In this post:
>
> ------Begin quote------
>
> Message from discussion Why Vaccines May Be Bad
>
> View parsed - Show only message text
>
> Path: g2news2.google.com!postnews.google.com!
> v25g2000yqk.googlegroups.com!not-for-mail
> From: Jan Drew <jdrew63...(a)aol.com>
> Newsgroups:
> sci.med,sci.med.nursing,sci.med.pharmacy,misc.health.alternative,misc.kids.�health
> Subject: Re: Why Vaccines May Be Bad
> Date: Sun, 21 Feb 2010 13:47:24 -0800 (PST)
> Organization:http://groups.google.com
> Lines: 8
> Message-ID: <c4bf5652-
> ccf4-4016-9801-1cf4730ab...(a)v25g2000yqk.googlegroups.com>
> References: <242544b1-bafb-4abd-9be8-
> e8752df05...(a)x22g2000yqx.googlegroups.com>
> � � � �
> <d6c8c599-bcd3-45bb-a2ca-cd208c0fb...(a)z1g2000prc.googlegroups.com>
> � � � �
> <ddf1c82b-77a5-4f3f-b0b4-edd4239ae...(a)15g2000yqi.googlegroups.com>
> � � � � <WoWdnVH3NPs25RzWnZ2dnUVZ_u5i4...(a)giganews.com>

Completely wrong, never have used giganews.com

> NNTP-Posting-Host: 205.188.116.65
> Mime-Version: 1.0
> Content-Type: text/plain; charset=UTF-8
> Content-Transfer-Encoding: quoted-printable
> X-Trace: posting.google.com 1266788844 891 127.0.0.1 (21 Feb 2010
> 21:47:24 GMT)
> X-Complaints-To: groups-abuse(a)google.com
> NNTP-Posting-Date: Sun, 21 Feb 2010 21:47:24 +0000 (UTC)
> Complaints-To: groups-abuse(a)google.com
> Injection-Info: v25g2000yqk.googlegroups.com; posting-
> host=205.188.116.65;
> � � � � posting-account=40HPKQoAAABwSFWWdvGlBjB7F-dFMkyi
> User-Agent: G2/1.0
> X-HTTP-Via: HTTP/1.1 (Velocity/3.1.1.5 [uScMs f p eN:t cCMp s ]),
> HTTP/
> 1.1
> � � � � spider-dtc-tf08.proxy.aol.com[CDBC70A8] (Prism/1.2.1),
> HTTP/1.1
> � � � � cache-dtc-ab01.proxy.aol.com[CDBC7441]
> (Traffic-Server/6.1.5 [uScM])
> X-HTTP-UserAgent: Mozilla/4.0 (compatible; MSIE 7.0; AOL 9.0; Windows
> NT 6.1;
> � � � � WOW64; Trident/4.0; SLCC2; .NET CLR 2.0.50727; .NET
> CLR
> 3.5.30729; .NET CLR
> � � � � 3.0.30729; Media Center PC 6.0),gzip(gfe),gzip(gfe)

Don't use any of that either, So much for Mark S Probert's
investigations skills.
>
> On Feb 21, 1:17=EF=BF=BDpm, dr_jeff <u...(a)msu.edu> wrote:
> �> Enough said.
>
> More than enough since you are not a doctor, but continue to lie.
>
> For a real M.D. �See:
>
> http://www.millerfamilymedicine.com/
> �-------End Quote_____
>
> Jan endorses Dr. Miller.
>
> I visited his website and can see that he is a hard working member of
> the medical profession.

You finally got something right.
>
> I also found links which resulted in these:
>
> "With proper hygiene and proper precautions, in addition to numerous
> vaccines and rapidly advancing medical technology, people are better
> equipped than ever to avoid getting sick."
>
> and
>
> http://www.ecommunity.com/health/index.aspx?pageid=P02523
>
> "The importance of immunizations:
> Immunization is key to preventing disease among the general
> population. Vaccines benefit both the people who receive them, and the
> vulnerable, unvaccinated people around them, because the infection can
> no longer spread. In addition, immunizations reduce the number of
> deaths and disability from infections, such as whooping cough and
> chickenpox.
>
> Although children receive the majority of the vaccinations, adults
> also need to stay up-to-date on certain vaccinations, including
> tetanus and diphtheria. In addition, those adults who have never had
> chickenpox or measles during childhood (nor the vaccines against these
> specific diseases) should consider being vaccinated. Childhood
> illnesses such as mumps, measles, and chickenpox can cause serious
> complications in adults.
>
> About guidelines for childhood immunizations:
> Many childhood diseases can now be prevented by following recommended
> guidelines for vaccinations:
>
> Meningococcal vaccine �- to protect against meningococcal disease.
> Hip B - to protect against hepatitis B.
> Polio vaccine �- to protect against polio.
> DTaP and Tdap - to protect against diphtheria, tetanus (lockjaw), and
> pertussis (whooping cough).
> Hib vaccine - to protect against Haemophilus influenzae type b (which
> causes spinal meningitis).
> MMR - to protect against measles, mumps and rubella (German measles).
> Pneumococcal vaccine �- to protect against pneumonia, infection in
> the
> blood, and meningitis.
> Varicella - to protect against chickenpox.
> RotaTeq� - to prevent rotavirus gastroenteritis in infants.
> Hep A - to prevent viral infection of the liver.
> HPV - to protect females from human papillomavirus, which is linked to
> cervical cancer. "
>
> and much more.
>
> Interestingly, Jan's "Real M.D." recommends the RotaTEQ vaccination
> invented by Dr. Paul Offit.
>
> I surely do wonder what Dr. Miller, who sounds like a really wonderful
> doctor, would say about Jan's incessent trashing of vaccinations and
> Dr. Offit?

Keep wondering. You might want to stop lying. I only post there are
no studies proving vaccination to be safe, You see I don't fall for
the lies of the CDC, FDA, or AMA, as they are *organized medicine*
And the fraud of all four including Offit, plus their vested interest,
=========================================================
So you wouldn't like the messages to include your rabid anti-vac and
pro-alternative health being brought up to him? You may have been far
too late. LOL

What happens when he answers someone and says that he DID give you shots
as normal?
What will happen if all your lies and hypocrisies are shown to the
church?
If you were a deaconess you soon won't be. ;)


From: Mike on
Mark Probert wrote:
> On Feb 24, 12:18 am, Mike <M...(a)localhost.localdomain> wrote:
>> Mark Probert wrote:
>>> In this post:
>>> ------Begin quote------
>>> Message from discussion Why Vaccines May Be Bad
>>> View parsed - Show only message text
>>> Path: g2news2.google.com!postnews.google.com!
>>> v25g2000yqk.googlegroups.com!not-for-mail
>>> From: Jan Drew <jdrew63...(a)aol.com>
>>> Newsgroups:
>>> sci.med,sci.med.nursing,sci.med.pharmacy,misc.health.alternative,misc.kids.�health
>>> Subject: Re: Why Vaccines May Be Bad
>>> Date: Sun, 21 Feb 2010 13:47:24 -0800 (PST)
>>> Organization:http://groups.google.com
>>> Lines: 8
>>> Message-ID: <c4bf5652-
>>> ccf4-4016-9801-1cf4730ab...(a)v25g2000yqk.googlegroups.com>
>>> References: <242544b1-bafb-4abd-9be8-
>>> e8752df05...(a)x22g2000yqx.googlegroups.com>
>>> <d6c8c599-bcd3-45bb-a2ca-cd208c0fb...(a)z1g2000prc.googlegroups.com>
>>> <ddf1c82b-77a5-4f3f-b0b4-edd4239ae...(a)15g2000yqi.googlegroups.com>
>>> <WoWdnVH3NPs25RzWnZ2dnUVZ_u5i4...(a)giganews.com>
>>> NNTP-Posting-Host: 205.188.116.65
>>> Mime-Version: 1.0
>>> Content-Type: text/plain; charset=UTF-8
>>> Content-Transfer-Encoding: quoted-printable
>>> X-Trace: posting.google.com 1266788844 891 127.0.0.1 (21 Feb 2010
>>> 21:47:24 GMT)
>>> X-Complaints-To: groups-ab...(a)google.com
>>> NNTP-Posting-Date: Sun, 21 Feb 2010 21:47:24 +0000 (UTC)
>>> Complaints-To: groups-ab...(a)google.com
>>> Injection-Info: v25g2000yqk.googlegroups.com; posting-
>>> host=205.188.116.65;
>>> posting-account=40HPKQoAAABwSFWWdvGlBjB7F-dFMkyi
>>> User-Agent: G2/1.0
>>> X-HTTP-Via: HTTP/1.1 (Velocity/3.1.1.5 [uScMs f p eN:t cCMp s ]), HTTP/
>>> 1.1
>>> spider-dtc-tf08.proxy.aol.com[CDBC70A8] (Prism/1.2.1), HTTP/1.1
>>> cache-dtc-ab01.proxy.aol.com[CDBC7441] (Traffic-Server/6.1.5 [uScM])
>>> X-HTTP-UserAgent: Mozilla/4.0 (compatible; MSIE 7.0; AOL 9.0; Windows
>>> NT 6.1;
>>> WOW64; Trident/4.0; SLCC2; .NET CLR 2.0.50727; .NET CLR
>>> 3.5.30729; .NET CLR
>>> 3.0.30729; Media Center PC 6.0),gzip(gfe),gzip(gfe)
>>> On Feb 21, 1:17=EF=BF=BDpm, dr_jeff <u...(a)msu.edu> wrote:
>>> > Enough said.
>>> More than enough since you are not a doctor, but continue to lie.
>>> For a real M.D. See:
>>> http://www.millerfamilymedicine.com/
>>> -------End Quote_____
>>> Jan endorses Dr. Miller.
>>> I visited his website and can see that he is a hard working member of
>>> the medical profession.
>>> I also found links which resulted in these:
>>> "With proper hygiene and proper precautions, in addition to numerous
>>> vaccines and rapidly advancing medical technology, people are better
>>> equipped than ever to avoid getting sick."
>>> and
>>> http://www.ecommunity.com/health/index.aspx?pageid=P02523
>> <irrelevant stuff snipped>
>>
>> Mark, you are an idiot. You followed a link athttp://www.millerfamilymedicine.com/, found more links at
>> the linked site and concluded that Dr.Miller endorsed whatever
>> is there. He may, or he may not, there is no evidence.
>
> Explain why he would link to information that he does not endorse. If
> you had a website, would you link to the CDC? Of course you wouldn't.

I do not have a website but I do not see a reason why not link
to CDC for reference for policy information, vaccination schedules etc.
Web sites have all kinds of links, for example, buzzflash.com
has a link to nypost.com, so what?

>
>> He does not "recommend immunizations". He has a generic link to a web
>> site that has a different page (not referred by him) that recommends
>> immunizations.
>
> See above, logic challenged one.

See above and below, logic challenged one.

>
>> And why does he have this link? Given these links and that his web site
>> and ecommunity.com have the same IP address 204.108.61.25 I would
>> suggest there is a relationship. Most likely, he is a member of
>> ecommunity.com (there is membership there), they may host his web site
>> in exchange for links, this is common practice.
>
> If he disagreed with the content, he could have separate hosting at
> another provider. If he is doing it to "save money" then you are
> calling him unethical. I do not see that.
>

Here is a better example - just for retards like you.

David Gorski aka Orac has a blog at http://scienceblogs.com/insolence/.
On the top of the page there are links. If you follow the link
"Medicine" you will get to
http://scienceblogs.com/channel/medicine/?utm_source=globalChannel&utm_medium=link

That page has an article called Autism and the Link to Infectious
Disease. Follow the link. Here is a quote:
-------------------------------------------------------------------
This might even explain why vaccines would lead to autism in some
children, because these viruses live and divide and grow in lymphocytes
-- the immune response cells, the B and the T cells. So when you give a
vaccine, you send your B and T cells in your immune system into overdrive.
-------------------------------------------------------------------

If "Orac" disagrees with this content he can have a separate hosting
at another provider, right? He used to have a page at oracknows.com,
let's see what links are there - oh, wait...

Did he abandon his domain to save money? Is he unethical? (To me, the
answers to both questions are obvious but unrelated to each other,)

>> Here is a web site of another member:http://www.arborlanemed.com
>
> Supports vaccinations.
>

About as much a "Orac" supports a possibility of a mechanism
linking vaccines to autism.

>> It looks very similar and has the same links.
>> Needless to say, same IP address.-
>
> Irrelevant.
>

Relevant. Membership based hosting, links mean business relation,
nothing else.
From: dr_jeff on
Jan Drew wrote:

> Keep wondering. You might want to stop lying. I only post there are
> no studies proving vaccination to be safe, You see I don't fall for
> the lies of the CDC, FDA, or AMA, as they are *organized medicine*
> And the fraud of all four including Offit, plus their vested interest,

Every single vaccine that is licensed for use in children is tested in
clinical trials.

For example, with Rotatec, the new rotavirus vaccine, 68,000 infants
were in a study that showed that it was safe and effective. If this is
not a study that shows that the vaccine is safe and effective, please
explain what kind of study should have been done.

Jeff

From the New England Journal of Medicine:

Safety and Efficacy of a Pentavalent Human�
Bovine (WC3) Reassortant Rotavirus Vaccine
Timo Vesikari, M.D., David O. Matson, M.D., Ph.D., Penelope Dennehy, M.D.,
Pierre Van Damme, M.D., Ph.D., Mathuram Santosham, M.D., M.P.H.,
Zoe Rodriguez, M.D., Michael J. Dallas, Ph.D., Joseph F. Heyse, Ph.D.,
Michelle G. Goveia, M.D., M.P.H., Steven B. Black, M.D., Henry R.
Shinefield, M.D.,
Celia D.C. Christie, M.D., M.P.H., Samuli Ylitalo, M.D., Robbin F.
Itzler, Ph.D.,
Michele L. Coia, B.A., Matthew T. Onorato, B.S., Ben A. Adeyi, M.P.H.,
Gary S. Marshall, M.D., Leif Gothefors, M.D., Dirk Campens, M.D.,
Aino Karvonen, M.D., James P. Watt, M.D., M.P.H.,
Katherine L. O�Brien, M.D., M.P.H., Mark J. DiNubile, M.D., H Fred
Clark, D.V.M., Ph.D.,
John W. Boslego, M.D., Paul A. Offit, M.D., and Penny M. Heaton, M.D.,
for the Rotavirus Efficacy and Safety Trial (REST) Study Team

Background
Rotavirus is a leading cause of childhood gastroenteritis and death
worldwide.


Methods
We studied healthy infants approximately 6 to 12 weeks old who were
randomly assigned to receive three oral doses of live pentavalent
human�bovine (WC3 strain) reassortant rotavirus vaccine containing human
serotypes G1, G2, G3, G4, and P[8] or placebo at 4-to-10-week intervals
in a blinded fashion. Active surveillance was used to identify subjects
with serious adverse and other events.

Results
The 34,035 infants in the vaccine group and 34,003 in the placebo group
were monitored for serious adverse events. Intussusception occurred in
12 vaccine recipients and 15 placebo recipients within one year after
the first dose including six vaccine recipients and five placebo
recipients within 42 days after any dose (relative risk, 1.6; 95 percent
confidence interval, 0.4 to 6.4). The vaccine reduced hospitalizations
and emergency department visits related to G1�G4 rotavirus
gastroenteritis occurring 14 or more days after the third dose by 94.5
percent (95 percent confidence interval, 91.2 to 96.6 percent). In a
nested substudy, efficacy against any G1�G4 rotavirus gastroenteritis
through the first full rotavirus season after vaccination was 74.0
percent (95 percent confidence interval, 66.8 to 79.9 percent); efficacy
against severe gastroenteritis was 98.0 percent (95 percent confidence
interval, 88.3 to 100 percent). The vaccine reduced clinic visits for
G1�G4 rotavirus gastroenteritis by 86.0 percent (95 percent confidence
interval, 73.9 to 92.5 percent).

Conclusions
This vaccine was efficacious in preventing rotavirus gastroenteritis,
decreasing severe disease and health care contacts. The risk of
intussusception was similar in vaccine and placebo recipients.
(ClinicalTrials.gov number, NCT00090233.)

From N Engl J Med 2006;354:23-33.