Vitamin K: The coagulation vitamin that became omnipotent.
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From: betaine_hcl on 1 Jul 2007 05:43 1: Thromb. Haemost. 2007 Jul;98(1):120-5. Vitamin K: The coagulation vitamin that became omnipotent. Cranenburg EC, Schurgers LJ, Vermeer C. Department of Biochemistry, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands. E-mail: c.vermeer(a)bioch.unimaas.nl. Vitamin K, discovered in the 1930s, functions as cofactor for the posttranslational carboxylation of glutamate residues. Gammacarboxy glutamic acid (Gla)-residues were first identified in prothrombin and coagulation factors in the 1970s; subsequently, extra-hepatic Gla proteins were described, including osteocalcin and matrix Gla protein (MGP). Impairment of the function of osteocalcin and MGP due to incomplete carboxylation results in an increased risk for developing osteoporosis and vascular calcification, respectively, and is an unexpected side effect of treatment with oral anticoagulants. It is conceivable that other side effects, possible involving growth-arrest-specific gene 6 (Gas6) protein will be identified in forthcoming years. In healthy individuals, substantial fractions of osteocalcin and MGP circulate as incompletely carboxylated species, indicating that the majority of these individuals is subclinically vitamin K-deficient. Potential new application areas for vitamin K are therefore its use in dietary supplements and functional foods for healthy individuals to prevent bone and vascular disease, as well as for patients on oral anticoagulant treatment to offer them protection against coumarin-induced side effects and to reduce diet-induced fluctuations in their INR values. PMID: 17598002 [PubMed - in process] Related Links Role of vitamin K and vitamin K-dependent proteins in vascular calcification. [Z Kardiol. 2001] PMID:11374034 Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. [J Biol Chem. 1985] PMID:3877721 Adverse effects of coumarin anticoagulants. [Drug Saf. 1993] PMID:8260120 Effects of vitamin K on bone mass and bone metabolism. [J Nutr. 1996] PMID:8642454 Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. [Arterioscler Thromb Vasc Biol. 2005] PMID:15961706
From: Juhana Harju on 1 Jul 2007 06:47 betaine_hcl(a)yahoo.com wrote: > 1: Thromb. Haemost. 2007 Jul;98(1):120-5. > > Vitamin K: The coagulation vitamin that > became omnipotent. > > Cranenburg EC, Schurgers LJ, Vermeer C. > > Department of Biochemistry, > University of Maastricht, > P.O. Box 616, 6200 MD > Maastricht, The Netherlands. > E-mail: c.vermeer(a)bioch.unimaas.nl. > > Vitamin K, discovered in the 1930s, functions as cofactor > for the posttranslational carboxylation of glutamate > residues. Gammacarboxy glutamic acid (Gla)-residues were > first identified in prothrombin and coagulation factors in > the 1970s; subsequently, extra-hepatic Gla proteins were > described, including osteocalcin and matrix Gla protein (MGP). > Impairment of the function of osteocalcin and MGP due to > incomplete carboxylation results in an increased risk for > developing osteoporosis and vascular calcification, respectively, > and is an unexpected side effect of treatment with oral > anticoagulants. > It is conceivable that other side effects, possible involving > growth-arrest-specific gene 6 (Gas6) protein will be > identified in forthcoming years. In healthy individuals, > substantial fractions of osteocalcin and MGP circulate > as incompletely carboxylated species, indicating that the > majority of these individuals is subclinically vitamin > K-deficient. Potential new application areas for vitamin K > are therefore its use in dietary supplements and functional > foods for healthy individuals to prevent bone and vascular > disease, as well as for patients on oral anticoagulant > treatment to offer them protection against coumarin-induced side > effects and to reduce diet-induced fluctuations in their INR values. > > PMID: 17598002 [PubMed - in process] Thanks for posting. I noticed that the full study is freely downloadable. http://www.schattauer.de/index.php?id=1268&pii=th07070120&no_cache=1 > Related Links > > Role of vitamin K and vitamin K-dependent proteins in vascular > calcification. [Z Kardiol. 2001] PMID:11374034 > > Primary structure of bovine matrix Gla protein, > a new vitamin K-dependent bone protein. [J Biol Chem. 1985] > PMID:3877721 > > Adverse effects of coumarin anticoagulants. > [Drug Saf. 1993] PMID:8260120 > > Effects of vitamin K on bone mass and bone metabolism. > [J Nutr. 1996] > PMID:8642454 > > Novel conformation-specific antibodies against > matrix gamma-carboxyglutamic acid (Gla) protein: > undercarboxylated matrix Gla protein as marker for vascular > calcification. [Arterioscler Thromb Vasc Biol. 2005] > PMID:15961706 -- Juhana
From: Ice Man on 8 Jul 2007 11:53 Nice find. Made me realize how useless my K-1 supplement is for preventing soft tissue calcification from D supplementation. I should be supplementing with K-2 instead, or perhaps both Ks.
From: trigonometry1972 on 27 Jul 2007 06:07 On Jul 8, 8:53 am, Ice Man <iceman458...(a)yahoo.com> wrote: > Nice find. Made me realize how useless my K-1 supplement is for > preventing soft tissue calcification from D supplementation. I should > be supplementing with K-2 instead, or perhaps both Ks. I'll add there are a couple of forms of vitamin K2 now available in supplement form. MK-4 and MK-7. LEF reformulated the supplement to contain both. And there is a vitamin K supplement derived from the fermented soy product Natto which I recall to be MK-7. Natto is said to be nasty as foods go, I guess it has a bad smell or taste?
From: Juhana Harju on 27 Jul 2007 12:37
trigonometry1972(a)gmail.com wrote: > On Jul 8, 8:53 am, Ice Man <iceman458...(a)yahoo.com> wrote: >> Nice find. Made me realize how useless my K-1 supplement is for >> preventing soft tissue calcification from D supplementation. I should >> be supplementing with K-2 instead, or perhaps both Ks. > > I'll add there are a couple of forms of vitamin K2 now available in > supplement form. MK-4 and MK-7. LEF reformulated the supplement > to contain both. And there is a vitamin K supplement derived from the > fermented > soy product Natto which I recall to be MK-7. Natto is said to be > nasty as foods go, I guess it has a bad smell or taste? First you get accustomed to it and eventually you will like it. :-P -- Juhana |