Prev: Glucose Intolerance and Hemosiderosis
Next: creatinine 3.0 GFR = 22
From: ironjustice on 11 Jul 2008 03:41
Effect of vitamin E-coated dialysis membranes on anemia in patients
with chronic kidney disease: An Italian multicenter study. Cruz DN, De
Cal M, Garzotto F, Brendolan A, Nalesso D, Corradi V, Ronco C
Int J Artif Organs 2008 Jun; 31(6):545-52.

Background: Increased oxidant stress is increasingly recognized as a
crucial factor in anemia in patients with chronic kidney disease.
Vitamin E-coated membranes (VECMs) consist of a multilayer membrane
with liposoluble vitamin E on the blood surface allowing direct free
radical scavenging at the membrane site, which is of potential
clinical benefit. Our objective was to examine the effect of VECMs on
anemia in chronic hemodialysis (HD).
Methods: We enrolled 172 stable chronic HD patients (94 men, 78 women,
age 65.4 +/- 13.4 years) in an open-label multicenter study. They were
shifted from their previous dialyzer to VECM for 1 year. Hemoglobin
(Hb) levels and recombinant human erythropoietin (rHuEpo) dosage were
analyzed after 4, 8, and 12 months on the VECM and compared with
baseline values using paired tests.
Results: Hb significantly increased from 10.9 +/- 1.2 g/dL at baseline
to 11.7 +/- 1.2 g/dL after 12 months (p<0.001) on VECMs. Conversely,
the rHuEpo dosage decreased from 7,762 +/- 5,865 IU/week at baseline
to 6,390 +/- 5,679 IU/week after 12 months (p<0.001). The proportion
of patients who were at target Hb levels (European Best Practice
Guidelines) increased from 49.4% at baseline to 80% after 12 months
(p<0.001).
Conclusions: Dialysis with VECM in stable chronic HD patients was
associated with significantly improved Hb levels and lower rHuEpo
requirements. These results suggest that the antioxidant properties of
VECMs may impact favorably on anemia management in chronic HD
patients. Possible mechanisms include enhanced membrane
biocompatibility, reduced oxidative stress and inflammation with
VECMs, resulting in improved red blood cell survival and/or rHuEpo
responsiveness. This therapy may potentially contribute to more
effective anemia management in hemodialysis patients, and merits
further rigorous study.

The International journal of artificial organs [Int J Artif Organs]
--------------------------------------------------------------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
 | 
Pages: 1
Prev: Glucose Intolerance and Hemosiderosis
Next: creatinine 3.0 GFR = 22