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From: ironjustice on 5 Oct 2008 16:01
Iron causes vitamin E deficiency AND vitamin D deficiency.
Vitamin E deficiency depletes vitamin D .

Phlebotomy / blood donation is KNOWN to increase vitamin D.

--------------

Vitamin D Deficiency May Cause Severe Muscle Weakness in Fibromyalgia

Endocrinologists at the University at Buffalo suggest that adults
afflicted with incapacitating muscle weakness and pain may be
suffering from an easily treatable vitamin D deficiency. A report by
Paresh Dandona, M.D. in the Archives of Internal Medicine (April 24,
2000) reported that five patients confined to wheelchairs because of
severe muscle weakness regained normal muscle strength after four to
six weeks of vitamin D supplementation.

This study was the first to describe cases of severe myopathy due to a
lack of vitamin D in the United States.

Vitamin D is produced by the liver in the presence of sufficient
calcium and sunlight.

Dandona, a native of India and educated in the United Kingdom, said
that individuals who have limited exposure to the sun are particularly
vulnerable to this condition. "In addition to osteomalacia (softening
of the bones), myopathy is a well-recognized feature of this
condition.”

"In the United States, vitamin D deficiency has only recently been
appreciated, especially in the northern areas bordering Canada. We see
vitamin D deficiency in the hospital setting and in the community at
large during the winter months, but in this country, there are no
reports of incapacitating muscle weakness associated with vitamin D
deficiency."

In each of his cases, the weakness had been attributed previously to
other causes: old age, problems associated with diabetes, and general
debility. "The diagnosis in these cases was either masked by the
presence of neurological disease or had been totally unrecognized
because of its insidious onset," said Dr. Dandona. Tests revealed
vitamin D deficiency in all five patients. After vitamin D replacement
therapy, four patients regained normal muscle strength and were able
to walk without support. The fifth -- the patient with anorexia
nervosa -- was able to stop using a wheelchair and walk with support.

Dr. Dandona listed the following situations that should raise
suspicions about a severe vitamin D deficiency:

limited sunlight exposure, due to climate or limited sun exposure
Body aches and pains, especially in the shins and ribs
Impaired absorption of nutrients


Vitamin D Deficiency Study Raises New Questions About Disease And
Supplements

------------------------

Increased oxidative stress suggested by low serum vitamin E
concentrations in patients with chronic fatigue syndrome.
Miwa K, Fujita M
Int J Cardiol 2008 Aug 4.

Serum alpha-tocopherol concentrations were determined in 50 patients
with chronic fatigue syndrome (CFS) and 40 control subjects
(Control).
Prevalence of each or any coronary risk factor was not significantly
different between CFS and Control. CFS had significantly lower alpha-
tocopherol concentrations than Control.
The concentrations were significantly lower in the subjects with any
coronary risk factors than those without in CFS as well as Control.
Even among the subjects with any coronary risk factors and also among
those without, CFS had significantly lower alpha-tocopherol
concentrations than Control.
In conclusion, CFS had significantly lower alpha-tocopherol
concentrations irrespective of coronary risk factors than Control,
suggesting the presence of increased oxidative stress in CFS.


International journal of cardiology [Int J Cardiol]


-----------------------


ScienceDaily (Jan. 27, 2008) — Low blood levels of vitamin D have long
been associated with disease, and the assumption has been that vitamin
D supplements may protect against disease. However, this new research
demonstrates that ingested vitamin D is immunosuppressive and that low
blood levels of vitamin D may be actually a result of the disease
process. Supplementation may make the disease worse.

In a new report Trevor Marshall, Ph.D., professor at Australia’s
Murdoch University School of Biological Medicine and Biotechnology,
explains how increased vitamin D intake affects much more than just
nutrition or bone health. The paper explains how the Vitamin D Nuclear
Receptor (VDR) acts in the repression or transcription of hundreds of
genes, including genes associated with diseases ranging from cancers
to multiple sclerosis.

"The VDR is at the heart of innate immunity, being responsible for
expression of most of the antimicrobial peptides, which are the body’s
ultimate response to infection," Marshall said.

"Molecular biology is now forcing us to re-think the idea that a low
measured value of vitamin D means we simply must add more to our diet.
Supplemental vitamin D has been used for decades, and yet the
epidemics of chronic disease, such as heart disease and obesity, are
just getting worse."

"Our disease model has shown us why low levels of vitamin D are
observed in association with major and chronic illness," Marshall
added. "Vitamin D is a secosteroid hormone, and the body regulates the
production of all it needs. In fact, the use of supplements can be
harmful, because they suppress the immune system so that the body
cannot fight disease and infection effectively."

Marshall's research has demonstrated how ingested vitamin D can
actually block VDR activation, the opposite effect to that of
Sunshine. Instead of a positive effect on gene expression, Marshall
reported that his own work, as well as the work of others, shows that
quite nominal doses of ingested vitamin D can suppress the proper
operation of the immune system. It is a different metabolite, a
secosteroid hormone called 1,25-dihydroxyvitamin D, which activates
the VDR to regulate the expression of the genes. Under conditions that
exist in infection or inflammation, the body automatically regulates
its production of all the vitamin D metabolites, including 25-
hydroxyvitamin D, the metabolite which is usually measured to indicate
vitamin D status.

Vitamin D deficiency, long interpreted as a cause of disease, is more
likely the result of the disease process, and increasing intake of
vitamin D often makes the disease worse. "Dysregulation of vitamin D
has been observed in many chronic diseases, including many thought to
be autoimmune," said J.C. Waterhouse, Ph.D., lead author of a book
chapter on vitamin D and chronic disease.

"We have found that vitamin D supplementation, even at levels many
consider desirable, interferes with recovery in these patients."

"We need to discard the notion that vitamin D affects a disease state
in a simple way," Marshall said. "Vitamin D affects the expression of
over 1,000 genes, so we should not expect a simplistic cause and
effect between vitamin D supplementation and disease. The
comprehensive studies are just not showing that supplementary vitamin
D makes people healthier."

Journal reference: Marshall TG. Vitamin D discovery outpaces FDA
decision making. Bioessays. 2008 Jan 15;30(2):173-182 [Epub ahead of
print] Online ISSN: 1521-1878 Print ISSN: 0265-9247 PMID: 18200565

Adapted from materials provided by Autoimmunity Research Foundation,
via AlphaGalileo.

--------------------------------------------------------------------------------

Bleeding / venesection / bloodletting / phlebotomy .. RESTORES ..
vitamin D .


"Low 25-OHD concentration is directly related to iron loading"
"Improved by venesection therapy."

"Iron may impair bone formation and aggravate osteomalacia."

Saccharated ferric oxide (SFO)-induced osteomalacia: in vitro
inhibition by SFO of bone formation and 1,25-dihydroxy-vitamin D
production in renal tubules.
Sato K, Nohtomi K, Demura H, Takeuchi A, Kobayashi T, Kazama J, Ozawa
H


Bone. 1997 Jul ; 21(1): 57-64


A 60-year-old man with portal hypertensive gastropathy due to type C
liver cirrhosis developed severe bone pains, marked hypophosphatemia
with inappropriately increased urinary excretion of phosphate (%TRP;
9.6%), and hyperalkaline phosphatasia, after intravenous
administration of saccharated ferric oxide (SFO) at a dose of 80-240
mg/week over a period of more than 5 years.
The total iron infused was estimated to be more than 25 g.
On a diagnosis of SFO-induced osteomalacia, the infusion of iron was
immediately discontinued, and phosphate and vitamin D2 (1000 IU/day)
were administered.
Serum levels of 25-OHD2 increased after 1 week, whereas levels of 1,25-
(OH)2D2 did not increase until 3 months later, accompanied by
improvement of renal tubular reabsorption of phosphate and gradual
improvement of the bone pains.
The patient has been doing well for the last 2 years, with normal
serum levels of phosphate, calcium, and alkaline phosphatase, without
any supplementation of phosphate, vitamin D, or iron-containing
agents.
In primary culture of neonatal mouse renal tubules, in which 1,25-
(OH)2D3 was produced from 25-OHD3 in response to PTH, SFO
significantly inhibited PTH-induced production of 1,25-(OH)2D3 at 30
mumol/L, which is attainable in the urine of patients receiving a
therapeutic intravenous dose of SFO.
Furthermore, SFO decreased the calcium content and inhibited 45Ca
incorporation in cultured fetal mouse parietal bones
at 3 mumol/L.
Such SFO concentration may be transiently observed in the
plasma of patients receiving excessive intravenous doses of SFO for a
prolonged period.
These in vitro findings together with the clinical observations
suggest that SFO, after filtration through the glomerulus
and reabsorption in the proximal renal tubules, impaired proximal
renal tubular function, such as tubular reabsorption of phosphate and
1 alpha-hydroxylase activity, leading to hypophosphatemic
osteomalacia.
Furthermore, it is highly likely that SFO in the peripheral blood,
when transferrin is saturated with iron, may impair bone formation and
aggravate osteomalacia.
Although SFO-induced osteomalacia is reversible
simply by discontinuation of the agent, excessive and prolonged
administration of SFO should be avoided.
---------------------------------------------------------------------------­­­----------------


1: Gastroenterology. 1985 Apr;88(4):865-9. Related Articles, Links


Low serum 25-hydroxyvitamin D in hereditary hemochromatosis: relation
to iron status.

Chow LH, Frei JV, Hodsman AB, Valberg LS.

Under normal conditions, vitamin D absorbed from the diet or
synthesized in the skin is transported to the liver where it undergoes
hydroxylation.
The purpose of this study was to determine whether
excess hepatic iron affects this process and the subsequent production
of 1,25-dihydroxyvitamin D (1,25-[OH]2D) in the kidney. Mean serum 25-
hydroxyvitamin D (25-OHD) concentrations in untreated hereditary
hemochromatosis were 13 +/- 6 (SD) in 9 patients with cirrhosis, 13
+/- 6 in 5 patients with hepatic fibrosis, and 22 +/- 6 in 10 patients
with normal hepatic architecture aside from siderosis and were
significantly lower than the levels found in 24 controls matched for
age, sex, and season, p less than 0.05.
The mean serum 25-OHD levels in the two groups with hemochromatosis
and hepatic damage were significantly lower
than the value in the group with normal hepatic architecture, p less
than 0.05.
Serum 25-OHD levels in individual patients were inversely
related to the size of body iron stores as measured by exchangeable
body iron, r = -0.64, or serum ferritin, r = -0.47, p less than 0.05.
In 15 patients removal of excess body iron by venesection therapy
produced a significant increase in the mean serum 25-OHD from 20 ng/ml
to 30 ng/ml, p less than 0.05. In contrast, mean serum 1,25-[OH]2D
levels were similar in iron-loaded and control subjects, indicating
that the regulation of this metabolite was intact in patients with
hemochromatosis.
The results reveal that the low serum 25-OHD
concentration in patients with hemochromatosis is directly related to
the extent of iron loading and it is improved by venesection therapy.


PMID: 3838288


----------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/634q5a


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
From: anonymous on 5 Oct 2008 16:45
Get Iron to Beat Fatigue

http://thyroid.about.com/cs/fatigueenergy/l/bliron.htm

October 2001 -- If you're one of the millions of women who experience
constant fatigue, an expert in women's and children's health says
taking a simple quiz for iron deficiency could be the first step on
the road to recovering your energy and vitality.
"Fatigue is the most common symptom of iron deficiency -- a
deficiency
that affects 25% of all women in North America," says Dr. Cathy
From: ironjustice on 6 Oct 2008 01:04
On Oct 5, 1:45 pm, anonym...(a)nowhere.you.know wrote:
iron deficiency -- a deficiency that affects 25% of all women in North
America," <<

These are well fed women.
THE best fed women of the whole world.

25% are iron deficient says Dr. Cathy.

Yeah .. right ..

The rest of the world must be .. screwed .. big time.

One wonders how the species .. survived .. without iron filings in all
our food.

"Human female is the only female of a species who is universally iron
deficient"

Iron deficiency protects the mother from gestational diabetes.
Iron deficiency protects the baby from malaria transferance from
mother.

Iron deficiency seems to be a good thing.

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


From: William R. Thompson on 6 Oct 2008 01:23
anonymous wrote:

> Get Iron to Beat Fatigue

If you have to reply to Rusty's rubbish, could you please remove
alt.support.lupus from the headers? None of this is on-topic
for ASL and we're tired of having his silliness clutter the group.

If you really want to give him attention, forward his posts to
his ISP's abuse department. That's abuse(a)telus.com. Include
the full message, its headers, a complaint about his activities
(off-topic, cross-posted, flooding, insulting, and all the other
abuses that define Tom Hennessy/Ironjustice) along with a copy
of your newsgroups' charter.

--Bill Thompson




From: ironjustice on 6 Oct 2008 02:20
On Oct 5, 10:23 pm, "William R. Thompson" <crea...(a)yadtel.net> wrote:
If you have to reply to Rusty's rubbish, could you please remove
alt.support.lupus from the headers?   <<

YOU **specifically** were TOLD to stay off my threads ..

You got some problem with those orders .. ?

Stay off my threads ..

On Oct 5, 10:23 pm, "William R. Thompson" <crea...(a)yadtel.net> wrote:
None of this is on-topic for ASL <<

Which one of the below is not related to lupus .. ?

Fibromyalgia .. ?
Chronic fatigue .. ?

You are STUPID .. ? .. or .. subversive ..

Which one ..

You gotta pick .. one ..

"Vitamin D Deficiency May Cause Severe Muscle Weakness in Fibromyalgia
Increased oxidative stress suggested by low serum vitamin E
concentrations in patients with chronic fatigue syndrome."


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




>
> If you really want to give him attention, forward his posts to
> his ISP's abuse department.  That's ab...(a)telus.com.  Include
> the full message, its headers, a complaint about his activities
> (off-topic, cross-posted, flooding, insulting, and all the other
> abuses that define Tom Hennessy/Ironjustice) along with a copy
> of your newsgroups' charter.
>
> --Bill Thompson

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