Vitamin C Injections Slow Tumor Growth In Mice
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From: Matti Narkia on 5 Aug 2008 05:38 The study Qi Chen, Michael Graham Espey, Andrew Y. Sun, Chaya Pooput, Kenneth L. Kirk, Murali C. Krishna, Deena Beneda Khosh, Jeanne Drisko, and Mark Levine. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. PNAS published ahead of print August 4, 2008 doi:10.1073/pnas.0804226105 <http://www.pnas.org/content/early/2008/08/01/0804226105.abstract> found that high-dose injections of vitamin C reduced tumor weight and growth rate by about 50 percent in mouse models of brain, ovarian, and pancreatic cancers. The researchers traced ascorbate's anti-cancer effect to the formation of hydrogen peroxide in the extracellular fluid surrounding the tumors. Normal cells were unaffected. Comments in Vitamin C Injections Slow Tumor Growth In Mice <http://www.sciencedaily.com/releases/2008/08/080804190645.htm> -- Matti Narkia http://ma.gnolia.com/groups/Nutrition
From: Matti Narkia on 5 Aug 2008 05:49 Matti Narkia wrote: > The study > > Qi Chen, Michael Graham Espey, Andrew Y. Sun, Chaya Pooput, Kenneth L. > Kirk, Murali C. Krishna, Deena Beneda Khosh, Jeanne Drisko, and Mark > Levine. > Pharmacologic doses of ascorbate act as a prooxidant and decrease > growth of aggressive tumor xenografts in mice. > PNAS published ahead of print August 4, 2008 > doi:10.1073/pnas.0804226105 > <http://www.pnas.org/content/early/2008/08/01/0804226105.abstract> > > found that high-dose injections of vitamin C reduced tumor weight > and growth rate by about 50 percent in mouse models of brain, ovarian, > and pancreatic cancers. The researchers traced ascorbate's anti-cancer > effect to the formation of hydrogen peroxide in the extracellular fluid > surrounding the tumors. Normal cells were unaffected. > > Comments in > > Vitamin C Injections Slow Tumor Growth In Mice > <http://www.sciencedaily.com/releases/2008/08/080804190645.htm> > Related earlier articles: Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14. PMID: 17502596 doi: 10.1073/pnas.0702854104 <http://www.pnas.org/content/104/21/8749> Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12. PMID: 16157892 doi: 10.1073/pnas.0506390102 <http://www.pnas.org/content/102/38/13604> Padayatty SJ, Levine M. Reevaluation of ascorbate in cancer treatment: emerging evidence, open minds and serendipity. J Am Coll Nutr. 2000 Aug;19(4):423-5. PMID: 10963459 <http://www.jacn.org/cgi/content/full/19/4/423> -- Matti Narkia http://ma.gnolia.com/groups/Nutrition
From: Matti Narkia on 5 Aug 2008 06:05 Matti Narkia wrote: > Matti Narkia wrote: > >> The study >> >> Qi Chen, Michael Graham Espey, Andrew Y. Sun, Chaya Pooput, Kenneth L. >> Kirk, Murali C. Krishna, Deena Beneda Khosh, Jeanne Drisko, and Mark >> Levine. >> Pharmacologic doses of ascorbate act as a prooxidant and decrease >> growth of aggressive tumor xenografts in mice. >> PNAS published ahead of print August 4, 2008 >> doi:10.1073/pnas.0804226105 >> <http://www.pnas.org/content/early/2008/08/01/0804226105.abstract> >> >> found that high-dose injections of vitamin C reduced tumor weight >> and growth rate by about 50 percent in mouse models of brain, ovarian, >> and pancreatic cancers. The researchers traced ascorbate's anti-cancer >> effect to the formation of hydrogen peroxide in the extracellular fluid >> surrounding the tumors. Normal cells were unaffected. >> >> Comments in >> >> Vitamin C Injections Slow Tumor Growth In Mice >> <http://www.sciencedaily.com/releases/2008/08/080804190645.htm> >> > Related earlier articles: > > Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, > Pooput C, Kirk KL, Buettner GR, Levine M. > Ascorbate in pharmacologic concentrations selectively generates > ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. > Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14. > PMID: 17502596 > doi: 10.1073/pnas.0702854104 > <http://www.pnas.org/content/104/21/8749> > > Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, > Shacter E, Levine M. > Pharmacologic ascorbic acid concentrations selectively kill cancer > cells: action as a pro-drug to deliver hydrogen peroxide to tissues. > Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12. > PMID: 16157892 > doi: 10.1073/pnas.0506390102 > <http://www.pnas.org/content/102/38/13604> > > Padayatty SJ, Levine M. > Reevaluation of ascorbate in cancer treatment: emerging evidence, open > minds and serendipity. > J Am Coll Nutr. 2000 Aug;19(4):423-5. > PMID: 10963459 > <http://www.jacn.org/cgi/content/full/19/4/423> > And here's a Korean trial with humans, probably with lower vitamin C concentrations than in the PNAS study: Yeom CH, Jung GC, Song KJ. Changes of terminal cancer patients' health-related quality of life after high dose vitamin C administration. J Korean Med Sci. 2007 Feb;22(1):7-11. PMID: 17297243 <http://jkms.org/fulltext/html/jkms227h.html> -- Matti Narkia http://ma.gnolia.com/groups/Nutrition
From: Taka on 5 Aug 2008 08:06 Have been telling you that previously - http://tinyurl.com/6h7af3 http://tinyurl.com/66w78p http://tinyurl.com/6zk4fr Well known fact already used in clinical trials and private clinics: http://www.drmagaziner.com/vitamin_c.htm http://www.lef.org:80/newsletter/2008/0104_Clinical-trial-vitamin-C-non-Hodgkin-lymphoma.htm http://www.lef.org/newsletter/2008/0805_High-Dose-Vitamin-C-Injections-Slash-Tumor-Growth-in-Mice.htm VitC+iron+PUFAs(n-3) = an efficient cancer chemotherapy. plus VitC is boosting immunity via arachidonic acid (AA) release My addition is no need for Fe which is abundant in vivo as Tom is constantly reminding us. And low carb or ketogenic diet prior to the VitC injection should increase the stem/cancer cell killing specificity (these types of cells thrive on sugar using glycolysis and will swallow tons of VitC when hungry for sugar so perhaps even oral VitC will do). And to guarantee success you can spice it with some "antioxidants" like resveratrol or catechin. Well for people with AA in their cells this may be the best cancer therapy option available today but when they beat cancer this way then they will have to start worrying about atherosclerosis resulting from the lipid peroxidation ... Taka On Aug 5, 7:38 pm, Matti Narkia <m...(a)mbnet.fi> wrote: > Matti Narkia wrote: > > Matti Narkia wrote: > > >> Matti Narkia wrote: > > >>> The study > > >>> Qi Chen, Michael Graham Espey, Andrew Y. Sun, Chaya Pooput, Kenneth L.. > >>> Kirk, Murali C. Krishna, Deena Beneda Khosh, Jeanne Drisko, and Mark > >>> Levine. > >>> Pharmacologic doses of ascorbate act as a prooxidant and decrease > >>> growth of aggressive tumor xenografts in mice. > >>> PNAS published ahead of print August 4, 2008 > >>> doi:10.1073/pnas.0804226105 > >>> <http://www.pnas.org/content/early/2008/08/01/0804226105.abstract> > > >>> found that high-dose injections of vitamin C reduced tumor weight > >>> and growth rate by about 50 percent in mouse models of brain, ovarian, > >>> and pancreatic cancers. The researchers traced ascorbate's anti-cancer > >>> effect to the formation of hydrogen peroxide in the extracellular fluid > >>> surrounding the tumors. Normal cells were unaffected. > > >>> Comments in > > >>> Vitamin C Injections Slow Tumor Growth In Mice > >>> <http://www.sciencedaily.com/releases/2008/08/080804190645.htm> > > >> Related earlier articles: > > >> Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, > >> Pooput C, Kirk KL, Buettner GR, Levine M. > >> Ascorbate in pharmacologic concentrations selectively generates > >> ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.. > >> Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14. > >> PMID: 17502596 > >> doi: 10.1073/pnas.0702854104 > >> <http://www.pnas.org/content/104/21/8749> > > >> Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, > >> Shacter E, Levine M. > >> Pharmacologic ascorbic acid concentrations selectively kill cancer > >> cells: action as a pro-drug to deliver hydrogen peroxide to tissues. > >> Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12. > >> PMID: 16157892 > >> doi: 10.1073/pnas.0506390102 > >> <http://www.pnas.org/content/102/38/13604> > > >> Padayatty SJ, Levine M. > >> Reevaluation of ascorbate in cancer treatment: emerging evidence, open > >> minds and serendipity. > >> J Am Coll Nutr. 2000 Aug;19(4):423-5. > >> PMID: 10963459 > >> <http://www.jacn.org/cgi/content/full/19/4/423> > > > And here's a Korean trial with humans, probably with lower vitamin C > > concentrations than in the PNAS study: > > > Yeom CH, Jung GC, Song KJ. > > Changes of terminal cancer patients' health-related quality of life > > after high dose vitamin C administration. > > J Korean Med Sci. 2007 Feb;22(1):7-11. > > PMID: 17297243 > > <http://jkms.org/fulltext/html/jkms227h.html> > > More articles about the same topic: > > Duconge J, Miranda-Massari JR, Gonzalez MJ, Jackson JA, Warnock W, > Riordan NH. > Pharmacokinetics of vitamin C: insights into the oral and intravenous > administration of ascorbate. > P R Health Sci J. 2008 Mar;27(1):7-19. Review. > PMID: 18450228 > <http://www.ncbi.nlm.nih.gov/pubmed/18450228> > > Stephenson CM, Levin RD, Lis CG. > Phase 1 trial of high-dose intravenous vitamin C treatment for patients > with cancer. > J Am Osteopath Assoc. 2007 Jun;107(6):212-3. > PMID: 17635899 > <http://www.jaoa.org/cgi/content/full/107/6/212> > > Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M. > Intravenously administered vitamin C as cancer therapy: three cases. > CMAJ. 2006 Mar 28;174(7):937-42. > PMID: 16567755 [PubMed - indexed for MEDLINE] > <http://www.cmaj.ca/cgi/content/full/174/7/937> > <http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubme....> > > S. Assouline and W. H. Miller > High-dose vitamin C therapy: renewed hope or false promise? > Can. Med. Assoc. J., March 28, 2006; 174(7): 956 - 957. > doi:10.1503/cmaj.060228. > <http://www.cmaj.ca/cgi/content/full/174/7/956> (full text) > > Riordan HD, Casciari JJ, Gonzalez MJ, Riordan NH, Miranda-Massari JR, > Taylor P, Jackson JA. > A pilot clinical study of continuous intravenous ascorbate in terminal > cancer patients. > P R Health Sci J. 2005 Dec;24(4):269-76. > PMID: 16570523 > <http://www.ncbi.nlm.nih.gov/pubmed/16570523> > > Casciari JJ, Riordan HD, Miranda-Massari JR, Gonzalez MJ. > Effects of high dose ascorbate administration on L-10 tumor growth in > guinea pigs. > P R Health Sci J. 2005 Jun;24(2):145-50. > PMID: 16116933 > <http://www.ncbi.nlm.nih.gov/pubmed/16116933> > > González MJ, Miranda-Massari JR, Mora EM, Guzmán A, Riordan NH, Riordan > HD, Casciari JJ, Jackson JA, Román-Franco A. > Abstract > Orthomolecular oncology review: ascorbic acid and cancer 25 years later. > Integr Cancer Ther. 2005 Mar;4(1):32-44. Review. > PMID: 15695476 > <http://ict.sagepub.com/cgi/content/abstract/4/1/32> > > Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, > Levine M. > Vitamin C pharmacokinetics: implications for oral and intravenous use. > Ann Intern Med. 2004 Apr 6;140(7):533-7. > PMID: 15068981 > <http://www.annals.org/cgi/content/full/140/7/533> > > Riordan HD, Riordan NH, Jackson JA, Casciari JJ, Hunninghake R, González > MJ, Mora EM, Miranda-Massari JR, Rosario N, Rivera A. > Intravenous vitamin C as a chemotherapy agent: a report on clinical cases.. > P R Health Sci J. 2004 Jun;23(2):115-8. > PMID: 15377059 > <http://www.ncbi.nlm.nih.gov/pubmed/15377059> > > González MJ, Miranda-Massari JR, Mora EM, Jiménez IZ, Matos MI, Riordan > HD, Casciari JJ, Riordan NH, Rodríguez M, Guzmán A. > Orthomolecular oncology: a mechanistic view of intravenous ascorbate's > chemotherapeutic activity. > P R Health Sci J. 2002 Mar;21(1):39-41. Review. > PMID: 12013679 > <http://www.ncbi.nlm.nih.gov/pubmed/12013679> > > Riordan NH, Riordan HD, Casciari JP. > Clinical and experimental experiences with intravenous vitamin > C. J Orthomol Med. 2000;15:201-213 > <http://orthomolecular.org/library/jom/2000/pdf/2000-v15n04-p201.pdf> > > Riordan NH, Riordan HD, Meng X, Li Y, Jackson JA. > Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. > Med Hypotheses. 1995 Mar;44(3):207-13. > PMID: 7609676 > doi:10.1016/0306-9877(95)90137-X > <http://www.ncbi.nlm.nih.gov/pubmed/7609676> > > -- > Matti Narkia > > http://ma.gnolia.com/groups/Nutrition
From: Matti Narkia on 5 Aug 2008 08:25
Trials recruiting cancer patients for intravenous (IV) vitamin C treatment: Study of High-Dose Intravenous (IV) Vitamin C Treatment in Patients With Solid Tumors <http://www.clinicaltrials.gov/ct2/show/NCT00441207?term=vitamin+C&rank=3> Pilot Trial of Intravenous Vitamin C in Refractory Non-Hodgkin Lymphoma (NHL <http://www.clinicaltrials.gov/ct2/show/NCT00626444?term=%22vitamin+C%22+lymphoma&rank=1> -- Matti Narkia http://ma.gnolia.com/groups/Nutrition |