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From: Matti Narkia on 5 Aug 2008 06:09
The study

Qi Chen, Michael Graham Espey, Andrew Y. Sun, Chaya Pooput, Kenneth L.
Kirk, Murali C. Krishna, Deena Beneda Khosh, Jeanne Drisko, and Mark
Levine.
Pharmacologic doses of ascorbate act as a prooxidant and decrease
growth of aggressive tumor xenografts in mice.
PNAS published ahead of print August 4, 2008
doi:10.1073/pnas.0804226105
<http://www.pnas.org/content/early/2008/08/01/0804226105.abstract>

found that high-dose injections of vitamin C reduced tumor weight
and growth rate by about 50 percent in mouse models of brain, ovarian,
and pancreatic cancers. The researchers traced ascorbate's anti-cancer
effect to the formation of hydrogen peroxide in the extracellular fluid
surrounding the tumors. Normal cells were unaffected.

Comments in

Vitamin C Injections Slow Tumor Growth In Mice
<http://www.sciencedaily.com/releases/2008/08/080804190645.htm>


Related earlier articles:

Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL,
Pooput C, Kirk KL, Buettner GR, Levine M.
Ascorbate in pharmacologic concentrations selectively generates
ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14.
PMID: 17502596
doi: 10.1073/pnas.0702854104
<http://www.pnas.org/content/104/21/8749>

Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR,
Shacter E, Levine M.
Pharmacologic ascorbic acid concentrations selectively kill cancer
cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12.
PMID: 16157892
doi: 10.1073/pnas.0506390102
<http://www.pnas.org/content/102/38/13604>

Padayatty SJ, Levine M.
Reevaluation of ascorbate in cancer treatment: emerging evidence, open
minds and serendipity.
J Am Coll Nutr. 2000 Aug;19(4):423-5.
PMID: 10963459
<http://www.jacn.org/cgi/content/full/19/4/423>

And here's a Korean trial with humans, probably with lower vitamin C
concentrations than in the PNAS study:

Yeom CH, Jung GC, Song KJ.
Changes of terminal cancer patients' health-related quality of life
after high dose vitamin C administration.
J Korean Med Sci. 2007 Feb;22(1):7-11.
PMID: 17297243
<http://jkms.org/fulltext/html/jkms227h.html>


--
Matti Narkia

http://ma.gnolia.com/groups/Nutrition
From: Matti Narkia on 5 Aug 2008 08:23
Additional link:

High doses of intravenous vitamin C fight cancer
(includes video)
<http://www.drmagaziner.com/vitamin_c.htm>

Trials recruiting cancer patients for intravenous (IV) vitamin C
treatment:

Clinical trial to test vitamin C against non-Hodgkin lymphoma
<http://www.lef.org/newsletter/2008/0104_Clinical-trial-vitamin-C-non-Hodgkin-lymphoma.htm>

Pilot Trial of Intravenous Vitamin C in Refractory Non-Hodgkin Lymphoma
(NHL
<http://www.clinicaltrials.gov/ct2/show/NCT00626444?term=%22vitamin+C%22+lymphoma&rank=1>

Study of High-Dose Intravenous (IV) Vitamin C Treatment in Patients
With Solid Tumors
<http://www.clinicaltrials.gov/ct2/show/NCT00441207?term=vitamin+C&rank=3>



--
Matti Narkia

http://ma.gnolia.com/groups/Nutrition
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