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From: Juhana Harju on 30 Nov 2007 02:37
Vitamin B supplementation seems to increase lumbar spine bone mineral
density in patients with high homocysteine.

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Clin Chem Lab Med. 2007 Nov 18; [Epub ahead of print]
The effect of B-vitamins on biochemical bone turnover markers and bone
mineral density in osteoporotic patients: a 1-year double blind placebo
controlled trial.
Herrmann M, Umanskaya N, Traber L, Schmidt-Gayk H, Menke W, Lanzer G,
Lenhart M, Peter Schmidt J, Herrmann W.
1ANZAC Research Institute, University of Sydney, Sydney NSW, Australia and
Department of Clinical Chemistry and Laboratory Medicine, University
Hospital of Saarland, Homburg/Saar, Germany.

Abstract Background: Hyperhomocysteinemia is a new risk factor for
osteoporosis. This study analyzed the effect of a homocysteine
(HCY)-lowering treatment in osteoporotic individuals. Methods: Osteoporotic
subjects (n=47, 55-82 years) were treated with either a combination of 2.5
mg folate, 0.5 mg vitamin B(12) and 25 mg vitamin B(6) or placebo. Bone
mineral density (BMD) at lumbar spine and hip was measured at baseline and
after 1 year. Urinary desoxypyridinoline cross-links (DPD) and plasma levels
of tartrate resistant acid phosphatase (TRAP), C-terminal cross-links of
collagen I (CTx), pro-collagen type I N-terminal peptide (PINP) and
osteocalcin (OC) were measured after 0, 4, 8 and 12 months. Results:
B-vitamin supplementation significantly reduced HCY (0 vs. 12 months:
13.6+/-4.8 vs. 8.9+/-2.4 mumol/L). Placebo treatment had no effect on HCY (0
vs. 12 months: 12.0+/-3.4 vs. 12.7+/-3.9mumol/L). BMD, TRAP, CTx, OC and
PINP did not change throughout the study in both groups. Vitamin treatment
decreased urinary DPD by -13% (p<0.01) after 8 and 12 months. In a sub-group
analysis of hyperhomocysteinemic subjects (HCY>15 mumol/L, n=8), B-vitamin
treatment tended to increase BMD at the lumbar spine, with a t-score
from -2.7 to -1.7, and to decrease OC and PINP by approximately 50%.
Conclusions: B-vitamin supplementation had no consistent effects on bone
turnover or BMD. However, the situation may be different in patients with
hyperhomocysteinemia. Clin Chem Lab Med 2007;45. PMID: 18020969

http://www.tinyurl.dk/2357

--
Juhana

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