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From: TX-012 on 15 Jul 2008 22:21
I'd be curious to know often this is seen in patients on hep c
treatment (and of course what the significance is)--the reason I was
on Norco and am now on OxyContin was because of the muscle/joint/
connective tissue pain which is certainly associated with inflamation--
my hands and knees, for example, often become somewhat swollen;
without opiates I essentially am a shuffling arthritic mess who can
barely open a jar...


Toxic granulation
From Wikipedia, the free encyclopedia
Toxic granulation refers to changes in granulocyte cells seen on
examination of the peripheral blood film of patients with inflammatory
conditions. They are commonly found in patients with sepsis. Toxic
granulations are dark coarse granules found in granulocytes,
particularly neutrophils. Along with Dohle bodies and cytosolic
vacuolation, which are two other findings in the cytoplasm of
granulocytes, toxic granulations are a peripheral blood film finding
suggestive of an inflammatory process.
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