Thyroid update
in [Panic]
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From: Sheldon on 23 Jun 2006 20:36 The second batch of tests came out mixed, but my doc said I definitely will need to go on thyroid meds, if not now in the near future. He said the THS test can fluctuate a lot, so even though it came down the other tests were up a bit. He's going to contact my pdoc, and when I see him next week I'll go over this with him. Both of these guys are excellent pharmacalogists, but they need to know what the other is doing. My doc at least warned me that the thyroid meds would make me hyper for a bit, until my body settles down, and has no problem with my titrating up in small doses, as you guys suggested. He also believes that there isn't enough evidence to say that cutting soy out of my diet will make my thyroid problems go away, and he's a young guy who definitely keeps up to date. I will, however, cut out the soy milk and go back to regular skim milk. So, at this point I'm kinda in limbo, but not to panic. Since both my mom and sister were on thyroid meds, I'd say it's safe to assume I'll be there at some time, maybe sooner than later. At least I feel in better hands than I did when the s**t hit the fan before. Oh, yeah. My blood pressure was down considerably, and I was really nervous when they took it, so that's really good. I guess the bottom line is if the thyroid meds will make me feel better I'm all for it, but I really like the calm I'm in with the SSRI's and benzos right now. Sheldon sheldon(a)sopris.net -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board(a)stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
From: Ian Rastall on 23 Jun 2006 21:26 On Fri, 23 Jun 2006 19:36:13 -0500, "Sheldon" <sheldon(a)REMOVEsopris.net> wrote: >I guess the bottom line is if the thyroid meds will make me feel better I'm >all for it, but I really like the calm I'm in with the SSRI's and benzos >right now. Hey Sheldon. I was on thyroid meds for a while ... can't remember what it was called ... and it didn't seem to make me hyper or over-anxious. I was hoping it would help me lose weight, but it didn't seem to do that, either. It was just there in my bloodstream, keeping my thyroid on track. Now I'm off it, as apparently it's gone back to normal. Hope you're well, Ian -- I'm sick of following my dreams. I'm just gonna ask where they're goin', and hook up with 'em later. (Mitch Hedburg) http://sundry.ws/ -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board(a)stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
From: margrove2 on 24 Jun 2006 00:02 On Fri, 23 Jun 2006 19:36:13 -0500, "Sheldon" <sheldon(a)REMOVEsopris.net> wrote: >The second batch of tests came out mixed, but my doc said I definitely will >need to go on thyroid meds, if not now in the near future. He said the THS >test can fluctuate a lot, so even though it came down the other tests were >up a bit. He's going to contact my pdoc, and when I see him next week I'll >go over this with him. Both of these guys are excellent pharmacalogists, >but they need to know what the other is doing. > >My doc at least warned me that the thyroid meds would make me hyper for a >bit, until my body settles down, and has no problem with my titrating up in >small doses, as you guys suggested. > >He also believes that there isn't enough evidence to say that cutting soy >out of my diet will make my thyroid problems go away, and he's a young guy >who definitely keeps up to date. I will, however, cut out the soy milk and >go back to regular skim milk. > >So, at this point I'm kinda in limbo, but not to panic. Since both my mom >and sister were on thyroid meds, I'd say it's safe to assume I'll be there >at some time, maybe sooner than later. At least I feel in better hands than >I did when the s**t hit the fan before. > >Oh, yeah. My blood pressure was down considerably, and I was really nervous >when they took it, so that's really good. > >I guess the bottom line is if the thyroid meds will make me feel better I'm >all for it, but I really like the calm I'm in with the SSRI's and benzos >right now. > >Sheldon >sheldon(a)sopris.net Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. I Thyroid. 2006; 16(3):249-58 (ISSN: 1050-7256) Messina M; Redmond G Department of Nutrition, School of Public Health, Loma Linda University, California, USA. markm(a)olympus.net Soy foods are a traditional staple of Asian diets but because of their purported health benefits they have become popular in recent years among non-Asians, especially postmenopausal women. There are many bioactive soybean components that may contribute to the hypothesized health benefits of soy but most attention has focused on the isoflavones, which have both hormonal and nonhormonal properties. However, despite the possible benefits concerns have been expressed that soy may be contraindicated for some subsets of the population. One concern is that soy may adversely affect thyroid function and interfere with the absorption of synthetic thyroid hormone. Thus, the purpose of this review is to evaluate the relevant literature and provide the clinician guidance for advising their patients about the effects of soy on thyroid function. In total, 14 trials (thyroid function was not the primary health outcome in any trial) were identified in which the effects of soy foods or isoflavones on at least one measure of thyroid function was assessed in presumably healthy subjects; eight involved women only, four involved men, and two both men and women. With only one exception, either no effects or only very modest changes were noted in these trials. Thus, collectively the findings provide little evidence that in euthyroid, iodine-replete individuals, soy foods, or isoflavones adversely affect thyroid function. In contrast, some evidence suggests that soy foods, by inhibiting absorption, may increase the dose of thyroid hormone required by hypothyroid patients. However, hypothyroid adults need not avoid soy foods. In addition, there remains a theoretical concern based on in vitro and animal data that in individuals with compromised thyroid function and/or whose iodine intake is marginal soy foods may increase risk of developing clinical hypothyroidism. Therefore, it is important for soy food consumers to make sure their intake of iodine is adequate. Article Tools Printer-Friendly Email This Download This View Online Email This Close Your Name: Your Email: Recipient's Email: Separate multiple email addresses with commas (Limit is 10). Subject: Optional Message: Download This Close MEDLINE Bookends Endnote Papyrus Procite Refman Quickdoc Format. Return To Search Results Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect. 2002; 110 Suppl 3:349-53 (ISSN: 0091-6765) Doerge DR; Sheehan DM Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA. Soy is known to produce estrogenic isoflavones. Here, we briefly review the evidence for binding of isoflavones to the estrogen receptor, in vivo estrogenicity and developmental toxicity, and estrogen developmental carcinogenesis in rats. Genistein, the major soy isoflavone, also has a frank estrogenic effect in women. We then focus on evidence from animal and human studies suggesting a link between soy consumption and goiter, an activity independent of estrogenicity. Iodine deficiency greatly increases soy antithyroid effects, whereas iodine supplementation is protective. Thus, soy effects on the thyroid involve the critical relationship between iodine status and thyroid function. In rats consuming genistein-fortified diets, genistein was measured in the thyroid at levels that produced dose-dependent and significant inactivation of rat and human thyroid peroxidase (TPO) in vitro. Furthermore, rat TPO activity was dose-dependently reduced by up to 80%. Although these effects are clear and reproducible, other measures of thyroid function in vivo (serum levels of triiodothyronine, thyroxine, and thyroid-stimulating hormone; thyroid weight; and thyroid histopathology) were all normal. Additional factors appear necessary for soy to cause overt thyroid toxicity. These clearly include iodine deficiency but may also include additional soy components, other defects of hormone synthesis, or additional goitrogenic dietary factors. Although safety testing of natural products, including soy products, is not required, the possibility that widely consumed soy products may cause harm in the human population via either or both estrogenic and goitrogenic activities is of concern. Rigorous, high-quality experimental and human research into soy toxicity is the best way to address these concerns. Similar studies in wildlife populations are also appropriate. Inhibition of thyroid peroxidase by Myrcia uniflora flavonoids. Chem Res Toxicol. 2006; 19(3):351-5 (ISSN: 0893-228X) Ferreira AC; Neto JC; da Silva AC; Kuster RM; Carvalho DP Laborat?rio de Fisiologia End?crina, Instituto de Biof?sica Carlos Chagas Filho, Brazil. Thyroid peroxidase (TPO), the key enzyme in thyroid hormone biosynthesis, is inhibited by dietary flavonoids; thus, a high consumption of plants containing inhibitory flavonoids may affect thyroid function and lead to hypothyroidism. In this work, TPO inhibition by the aqueous partition of Myrcia uniflora and its isolated compounds has been evaluated. The aqueous partition of the methanolic extract of M. uniflora is able to inhibit TPO activity in vitro. Two known flavonoids were isolated and characterized by mass spectrometry and (1)H NMR from plant extracts: mearnsitrin and myricitrin. The degree of TPO inhibition produced by the aqueous solution of the flavonoids was very high, with a 50% inhibition of the original TPO activity (IC(50)) obtained at 1.97 microM mearnsitrin and at 2.88 microM myricitrin. These results suggest that the indiscriminated consumption of M. uniflora pharmaceutical products allied to the nutritional deficiency of iodine might contribute to the development of hypothyroidism and goiter. show your doc these few of hundreds of peer reviewed studies that equivocally demonstrate the relationship of soy isoflavones to thyroid function -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board(a)stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
From: Sheldon on 24 Jun 2006 00:04 "Ian Rastall" <idrastall(a)gmail.com> wrote in message news:5v4p92dvf2k8fca2kr78d6v6rtc65cv0ho(a)4ax.com... > On Fri, 23 Jun 2006 19:36:13 -0500, "Sheldon" > <sheldon(a)REMOVEsopris.net> wrote: > >>I guess the bottom line is if the thyroid meds will make me feel better >>I'm >>all for it, but I really like the calm I'm in with the SSRI's and benzos >>right now. > > Hey Sheldon. I was on thyroid meds for a while ... can't remember what > it was called ... and it didn't seem to make me hyper or over-anxious. > I was hoping it would help me lose weight, but it didn't seem to do > that, either. It was just there in my bloodstream, keeping my thyroid > on track. Now I'm off it, as apparently it's gone back to normal. > > Hope you're well, > > Ian > -- I'm feeling pretty good, thank you. I've heard your story from quite a few people, and my doc told me a lot of people want to boost a normal thyroid hoping to lose weight. The last time I was on thyroid meds I was walking on the ceiling, and not in a good way. Since you are in this group, did being on the meds have any affect on your condition, whatever it might be? Right now I've got my GAD under control, and I like being calm. Sheldon -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board(a)stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
From: Ian Rastall on 24 Jun 2006 01:12 On Fri, 23 Jun 2006 23:04:02 -0500, "Sheldon" <sheldon(a)XXXXXXXXsopris.net> wrote: >did being on the meds have any affect on your >condition, whatever it might be? No, it had no effect. I think perhaps I spoke out of turn, as possibly you were on a higher dose than I was, when you were bouncing off the walls. I don't think my dose was that high, as the thyroid problem wasn't that severe. I have a doc that loves to medicate. I've had to talk him out of medicine on several occasions. Boy, you really threw me for a loop at first, when you said you'd heard my story from many people. I thought, "How many people know I had a thyroid condition? Is it all over the Internet? Do I have to cancel some Google posts or something?" :-) Anyway, hope you're well, and that this new round of thyroid meds doesn't upset your GAD. Ian -- I'm sick of following my dreams. I'm just gonna ask where they're goin', and hook up with 'em later. (Mitch Hedburg) http://sundry.ws/ -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board(a)stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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