Thyroid and Hair
in [Thyroid]
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From: Rod on 31 Aug 2008 07:30 One very commonly reported problem of thyroid disease is its effect on hair. The problems include loss of hair (falling out, thinning), changes of colour, changes of texture and 'feel' and changes of growth rate. Many report hair loss when they commence treatment or when they change mediciation. Many sufferers are clearly distressed by these symptoms. (Sorry - the pun was not intended.) But, in some ways worse, many are told that their hair problems are nothing to do with thyroid. Below a newly published paper which claims "the first evidence that human HFs [Hair Follicles] are direct targets of thyroid hormones". Are you worth it? :-) =============== J Clin Endocrin Metab. First published ahead of print August 26, 2008 as doi:10.1210/jc.2008-0283 Thyroid hormones directly alter human hair follicle functions: Anagen prolongation, and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation Nina van Beek [1#], Enikő Bodó [1#], Arno Kromminga [2], Erzsébet Gáspár [1], Katja Meyer [1], Michal A. Zmijewski [3], Andrzej Slominski [3], Björn E. Wenzel [4], Ralf Paus [1§] #contributed equally 1 Department of Dermatology, University of Lübeck, Lübeck, Germany; 2 Institute for Immunology, Clinical Pathology, Molecular Medicine, Hamburg, Germany; 3 Department of Pathology and Laboratory Medicine, and Center for Cancer Research, University of Tennessee, Memphis, Tennessee, USA; 4 Cell and Immunobiological Laboratory, Department of Med. I, University of Lübeck, Lübeck, Germany ABSTRACT Context: Both, insufficient and excess levels of thyroid hormones (T3, T4) can result in altered hair/skin structure and function (e.g. effluvium). However, it is still unclear whether T3/T4 exert any direct effects on human hair follicles (HFs), and if so – how exactly human HFs respond to T3/T4 stimulation. Objective: to asses the impact of T3/T4 on human hair follicle in vitro. Methods: Human anagen HFs were isolated from skin obtained from females undergoing face-lift surgery. Hair follicles from euthyroid females between 40 and 69 years (average: 56 years) were cultured an treated with T3/T4. Results: Studying microdissected, organ-cultured normal human scalp HFs, we show here that T4 upregulates the proliferation of hair matrix keratinocytes, while their apoptosis is downregulated by T3 and T4. T4 also prolongs the duration of the hair growth phase (anagen) in vitro, possibly due to the down-regulation of TGFβ2, the key anagen-inhibitory growth factor. Since we show here that human HFs transcribe deiodinase genes (D2 and D3), they may be capable of converting T4 to T3. Intrafollicular immunoreactivity (IR) for the recognized thyroid hormone-responsive keratins CK6 and CK14 is significantly modulated by T3 and T4 (CK6: enhanced, CK14: down-regulated). Both T3 and T4 also significantly stimulate intrafollicular melanin synthesis. Conclusions: Thus, we present the first evidence that human HFs are direct targets of thyroid hormones, and demonstrate that T3 and/or T4 modulate multiple hair biology parameters, ranging from HF cycling to pigmentation. =============== Full paper (as PDF) freely available here: <http://jcem.endojournals.org/cgi/rapidpdf/jc.2008-0283v1> -- Rod Hypothyroidism is a seriously debilitating condition with an insidious onset. Although common it frequently goes undiagnosed. <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>
From: Jessica on 31 Aug 2008 20:44 On Aug 31, 7:30 am, Rod <polygo...(a)ntlworld.com> wrote: > One very commonly reported problem of thyroid disease is its effect on > hair. The problems include loss of hair (falling out, thinning), changes > of colour, changes of texture and 'feel' and changes of growth rate. > Many report hair loss when they commence treatment or when they change > mediciation. > > Many sufferers are clearly distressed by these symptoms. (Sorry - the > pun was not intended.) But, in some ways worse, many are told that their > hair problems are nothing to do with thyroid. > > Below a newly published paper which claims "the first evidence that > human HFs [Hair Follicles] are direct targets of thyroid hormones". > > Are you worth it? :-) > > =============== > > J Clin Endocrin Metab. First published ahead of print August 26, 2008 as > doi:10.1210/jc.2008-0283 > > Thyroid hormones directly alter human hair follicle functions: > Anagen prolongation, and stimulation of both hair matrix keratinocyte > proliferation and hair pigmentation > > Nina van Beek [1#], EnikÅ Bodó [1#], Arno Kromminga [2], Erzsébet Gáspár > [1], Katja Meyer [1], Michal A. Zmijewski [3], Andrzej Slominski [3], > Björn E. Wenzel [4], Ralf Paus [1§] > > #contributed equally > 1 Department of Dermatology, University of Lübeck, Lübeck, Germany; > 2 Institute for Immunology, Clinical Pathology, Molecular Medicine, > Hamburg, Germany; > 3 Department of Pathology and Laboratory Medicine, and Center for Cancer > Research, University of Tennessee, Memphis, Tennessee, USA; > 4 Cell and Immunobiological Laboratory, Department of Med. I, University > of Lübeck, Lübeck, Germany > > ABSTRACT > > Context: > > Both, insufficient and excess levels of thyroid hormones (T3, T4) can > result in altered hair/skin structure and function (e.g. effluvium). > However, it is still unclear whether T3/T4 exert any direct effects on > human hair follicles (HFs), and if so â how exactly human HFs respond to > T3/T4 stimulation. > > Objective: > > to asses the impact of T3/T4 on human hair follicle in vitro. > > Methods: > > Human anagen HFs were isolated from skin obtained from females > undergoing face-lift surgery. Hair follicles from euthyroid females > between 40 and 69 years (average: 56 years) were cultured an treated > with T3/T4. > > Results: > > Studying microdissected, organ-cultured normal human scalp HFs, we show > here that T4 upregulates the proliferation of hair matrix keratinocytes, > while their apoptosis is downregulated by T3 and T4. T4 also prolongs > the duration of the hair growth phase (anagen) in vitro, possibly due to > the down-regulation of TGFβ2, the key anagen-inhibitory growth factor. > Since we show here that human HFs transcribe deiodinase genes (D2 and > D3), they may be capable of converting T4 to T3. > > Intrafollicular immunoreactivity (IR) for the recognized thyroid > hormone-responsive keratins CK6 and CK14 is significantly modulated by > T3 and T4 (CK6: enhanced, CK14: down-regulated). Both T3 and T4 also > significantly stimulate intrafollicular melanin synthesis. > > Conclusions: > > Thus, we present the first evidence that human HFs are direct targets of > thyroid hormones, and demonstrate that T3 and/or T4 modulate multiple > hair biology parameters, ranging from HF cycling to pigmentation. > > =============== > > Full paper (as PDF) freely available here: > > <http://jcem.endojournals.org/cgi/rapidpdf/jc.2008-0283v1> > > -- > Rod > > Hypothyroidism is a seriously debilitating condition with an insidious > onset. > Although common it frequently goes undiagnosed. > <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org> Rod, Until I joined this group I had no idea that the change in texture and the new thin-ness of my hair had anything to do with my thyroid. But, thank God, my medication is working and my last lab results came back with numbers in the normal range (yay!). I've noticed that over the past month or so my hair feels so much softer, looks shinier and even feels a little thicker. There is, without a doubt, a correlation between thyroid and hair. Jessica
From: Rod on 1 Sep 2008 00:24 Jessica wrote: > On Aug 31, 7:30 am, Rod <polygo...(a)ntlworld.com> wrote: >> One very commonly reported problem of thyroid disease is its effect on >> hair. The problems include loss of hair (falling out, thinning), changes >> of colour, changes of texture and 'feel' and changes of growth rate. >> Many report hair loss when they commence treatment or when they change >> mediciation. >> >> Many sufferers are clearly distressed by these symptoms. (Sorry - the >> pun was not intended.) But, in some ways worse, many are told that their >> hair problems are nothing to do with thyroid. >> >> Below a newly published paper which claims "the first evidence that >> human HFs [Hair Follicles] are direct targets of thyroid hormones". >> >> Are you worth it? :-) >> >> =============== >> >> J Clin Endocrin Metab. First published ahead of print August 26, 2008 as >> doi:10.1210/jc.2008-0283 >> >> Thyroid hormones directly alter human hair follicle functions: >> Anagen prolongation, and stimulation of both hair matrix keratinocyte >> proliferation and hair pigmentation >> >> Nina van Beek [1#], Enikő Bodó [1#], Arno Kromminga [2], Erzsébet Gáspár >> [1], Katja Meyer [1], Michal A. Zmijewski [3], Andrzej Slominski [3], >> Björn E. Wenzel [4], Ralf Paus [1§] >> >> #contributed equally >> 1 Department of Dermatology, University of Lübeck, Lübeck, Germany; >> 2 Institute for Immunology, Clinical Pathology, Molecular Medicine, >> Hamburg, Germany; >> 3 Department of Pathology and Laboratory Medicine, and Center for Cancer >> Research, University of Tennessee, Memphis, Tennessee, USA; >> 4 Cell and Immunobiological Laboratory, Department of Med. I, University >> of Lübeck, Lübeck, Germany >> >> ABSTRACT >> >> Context: >> >> Both, insufficient and excess levels of thyroid hormones (T3, T4) can >> result in altered hair/skin structure and function (e.g. effluvium). >> However, it is still unclear whether T3/T4 exert any direct effects on >> human hair follicles (HFs), and if so – how exactly human HFs respond to >> T3/T4 stimulation. >> >> Objective: >> >> to asses the impact of T3/T4 on human hair follicle in vitro. >> >> Methods: >> >> Human anagen HFs were isolated from skin obtained from females >> undergoing face-lift surgery. Hair follicles from euthyroid females >> between 40 and 69 years (average: 56 years) were cultured an treated >> with T3/T4. >> >> Results: >> >> Studying microdissected, organ-cultured normal human scalp HFs, we show >> here that T4 upregulates the proliferation of hair matrix keratinocytes, >> while their apoptosis is downregulated by T3 and T4. T4 also prolongs >> the duration of the hair growth phase (anagen) in vitro, possibly due to >> the down-regulation of TGFβ2, the key anagen-inhibitory growth factor. >> Since we show here that human HFs transcribe deiodinase genes (D2 and >> D3), they may be capable of converting T4 to T3. >> >> Intrafollicular immunoreactivity (IR) for the recognized thyroid >> hormone-responsive keratins CK6 and CK14 is significantly modulated by >> T3 and T4 (CK6: enhanced, CK14: down-regulated). Both T3 and T4 also >> significantly stimulate intrafollicular melanin synthesis. >> >> Conclusions: >> >> Thus, we present the first evidence that human HFs are direct targets of >> thyroid hormones, and demonstrate that T3 and/or T4 modulate multiple >> hair biology parameters, ranging from HF cycling to pigmentation. >> >> =============== >> >> Full paper (as PDF) freely available here: >> >> <http://jcem.endojournals.org/cgi/rapidpdf/jc.2008-0283v1> >> >> -- >> Rod >> >> Hypothyroidism is a seriously debilitating condition with an insidious >> onset. >> Although common it frequently goes undiagnosed. >> <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org> > > Rod, > Until I joined this group I had no idea that the change in texture and > the new thin-ness of my hair had anything to do with my thyroid. But, > thank God, my medication is working and my last lab results came back > with numbers in the normal range (yay!). I've noticed that over the > past month or so my hair feels so much softer, looks shinier and even > feels a little thicker. There is, without a doubt, a correlation > between thyroid and hair. > Jessica See - you were worth it! Modelling career beckons. :-) To my mind, one of the oddest symptoms of hypoT is loss of the outer third of the eyebrows. It would make more sense to me if it were overall thinning or total loss. Mind, for the record, there are apparently other possible causes. Possibly completely bogus thought - funny that some versions of Head and Shoulders anti-dandruff shampoo contain selenium. (Might not apply in all markets.) -- Rod Hypothyroidism is a seriously debilitating condition with an insidious onset. Although common it frequently goes undiagnosed. <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>
From: Dee on 1 Sep 2008 09:54 In the last few years I've had two major bouts of hair loss - both times after periods of really bad stress. Really noticeable thinning. But, luckily, my hair seems to have grown back, although maybe not quite a full as before. When the hair loss got really noticeable, I started taking Silica Gel (you get it at the health food store). It put a stop to the hair loss. My eyebrows have been thinner for quite a few years, too. And, I started turning grey when I was in my early twenties. I'm not fully grey now; but I have grey 'highlights'. Dee "Rod" <polygonum(a)ntlworld.com> wrote in message news:6i193vFojmstU1(a)mid.individual.net... > Jessica wrote: >> On Aug 31, 7:30 am, Rod <polygo...(a)ntlworld.com> wrote: >>> One very commonly reported problem of thyroid disease is its effect on >>> hair. The problems include loss of hair (falling out, thinning), changes >>> of colour, changes of texture and 'feel' and changes of growth rate. >>> Many report hair loss when they commence treatment or when they change >>> mediciation. >>> >>> Many sufferers are clearly distressed by these symptoms. (Sorry - the >>> pun was not intended.) But, in some ways worse, many are told that their >>> hair problems are nothing to do with thyroid. >>> >>> Below a newly published paper which claims "the first evidence that >>> human HFs [Hair Follicles] are direct targets of thyroid hormones". >>> >>> Are you worth it? :-) >>> >>> =============== >>> >>> J Clin Endocrin Metab. First published ahead of print August 26, 2008 as >>> doi:10.1210/jc.2008-0283 >>> >>> Thyroid hormones directly alter human hair follicle functions: >>> Anagen prolongation, and stimulation of both hair matrix keratinocyte >>> proliferation and hair pigmentation >>> >>> Nina van Beek [1#], Eniko Bod� [1#], Arno Kromminga [2], Erzs�bet G�sp�r >>> [1], Katja Meyer [1], Michal A. Zmijewski [3], Andrzej Slominski [3], >>> Bj�rn E. Wenzel [4], Ralf Paus [1�] >>> >>> #contributed equally >>> 1 Department of Dermatology, University of L�beck, L�beck, Germany; >>> 2 Institute for Immunology, Clinical Pathology, Molecular Medicine, >>> Hamburg, Germany; >>> 3 Department of Pathology and Laboratory Medicine, and Center for Cancer >>> Research, University of Tennessee, Memphis, Tennessee, USA; >>> 4 Cell and Immunobiological Laboratory, Department of Med. I, University >>> of L�beck, L�beck, Germany >>> >>> ABSTRACT >>> >>> Context: >>> >>> Both, insufficient and excess levels of thyroid hormones (T3, T4) can >>> result in altered hair/skin structure and function (e.g. effluvium). >>> However, it is still unclear whether T3/T4 exert any direct effects on >>> human hair follicles (HFs), and if so - how exactly human HFs respond to >>> T3/T4 stimulation. >>> >>> Objective: >>> >>> to asses the impact of T3/T4 on human hair follicle in vitro. >>> >>> Methods: >>> >>> Human anagen HFs were isolated from skin obtained from females >>> undergoing face-lift surgery. Hair follicles from euthyroid females >>> between 40 and 69 years (average: 56 years) were cultured an treated >>> with T3/T4. >>> >>> Results: >>> >>> Studying microdissected, organ-cultured normal human scalp HFs, we show >>> here that T4 upregulates the proliferation of hair matrix keratinocytes, >>> while their apoptosis is downregulated by T3 and T4. T4 also prolongs >>> the duration of the hair growth phase (anagen) in vitro, possibly due to >>> the down-regulation of TGF?2, the key anagen-inhibitory growth factor. >>> Since we show here that human HFs transcribe deiodinase genes (D2 and >>> D3), they may be capable of converting T4 to T3. >>> >>> Intrafollicular immunoreactivity (IR) for the recognized thyroid >>> hormone-responsive keratins CK6 and CK14 is significantly modulated by >>> T3 and T4 (CK6: enhanced, CK14: down-regulated). Both T3 and T4 also >>> significantly stimulate intrafollicular melanin synthesis. >>> >>> Conclusions: >>> >>> Thus, we present the first evidence that human HFs are direct targets of >>> thyroid hormones, and demonstrate that T3 and/or T4 modulate multiple >>> hair biology parameters, ranging from HF cycling to pigmentation. >>> >>> =============== >>> >>> Full paper (as PDF) freely available here: >>> >>> <http://jcem.endojournals.org/cgi/rapidpdf/jc.2008-0283v1> >>> >>> -- >>> Rod >>> >>> Hypothyroidism is a seriously debilitating condition with an insidious >>> onset. >>> Although common it frequently goes undiagnosed. >>> <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org> >> >> Rod, >> Until I joined this group I had no idea that the change in texture and >> the new thin-ness of my hair had anything to do with my thyroid. But, >> thank God, my medication is working and my last lab results came back >> with numbers in the normal range (yay!). I've noticed that over the >> past month or so my hair feels so much softer, looks shinier and even >> feels a little thicker. There is, without a doubt, a correlation >> between thyroid and hair. >> Jessica > > See - you were worth it! Modelling career beckons. :-) > > To my mind, one of the oddest symptoms of hypoT is loss of the outer third > of the eyebrows. It would make more sense to me if it were overall > thinning or total loss. Mind, for the record, there are apparently other > possible causes. > > Possibly completely bogus thought - funny that some versions of Head and > Shoulders anti-dandruff shampoo contain selenium. (Might not apply in all > markets.) > > -- > Rod > > Hypothyroidism is a seriously debilitating condition with an insidious > onset. > Although common it frequently goes undiagnosed. > <www.thyromind.info> <www.thyroiduk.org> <www.altsupportthyroid.org>
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