Thrombosis
in [Lupus]
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From: ironjustice on 18 Aug 2008 11:17 "Risk of thrombosis was proportional to elevation in hematocrit." Somehow those with lupus "DON'T have increased red blood cell production and hemolysis / polycythemia / erythrocytosis / iron overload " .. even though all markers say they doooo. Thrombosis is high in lupus and it is proportional TO **the hematocrit** .. higher red blood cells. Higher the red blood cells the higher the coaguability and visa versa. http://www.accessmedicine.com/content.aspx?aid=2144261 Williams Hematology, 7e Part V. The Erythrocyte > Therapy Sections: Polycythemia Vera, Plethoric Phase, Phlebotomy, Myelosuppression, Hydroxyurea, Busulfan, Radioactive Phosphorus, Interferon, Pipobroman, Anagrelide, Imatinib Mesylate, Symptomatic Therapy for Pruritus, Aspirin, Hydration, Spent Phase, Splenectomy, Thalidomide, Marrow Transplantation, JAK2 Targeted Inhibitors, Other Polycythemias. Topics Discussed: anagrelide hydrochloride; aspirin; bone marrow transplant; busulfan; erythrocytosis; erythrocytosis due to low atmospheric pressure; hydroxyurea; imatinib mesylate; interferon- alpha; myelosuppression; phlebotomy; pipobroman; polycythemia vera; post transplant erythrocytosis; pruritus; secondary polycythemia; splenectomy; thalidomide. Excerpt: "The treatment of patients in the plethoric phase of the disease is aimed at ameliorating symptoms and decreasing the risk of thrombosis or bleeding by reducing the blood counts. The red count and hematocrit can be controlled in some patients by periodic phlebotomy, but administration of drugs that suppress marrow activity also is required to control the platelet and white counts. Both treatment modalities are used in most patients. Table 56-4 summarizes the advantages and disadvantages of various forms of therapy.The usual initial treatment for most patients is phlebotomy.50,238 The rationale for phlebotomy therapy of polycythemia vera is based on a widely quoted paper that suggested that the risk of thrombosis in polycythemia vera was proportional to the elevation in hematocrit.239 The underlying mechanisms causing thrombosis in polycythemia vera are not fully known, but the hematocrit likely is not the only, and may not even be the principal, risk factor. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/634q5a Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
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