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From: ironjustice on 3 Oct 2008 09:29
On Aug 10, 9:03 pm, ironjustice <ironjust...(a)cashette.com> wrote:
http://tinyurl.com/6chtoe "None developedhepatocellularcarcinoma
(HCC).
<<

Liver Transplant Recipients Almost 3 Times More Likely To Develop
Cancer

Cancer incidence is higher among liver transplant recipients in
Finland compared to the general population, according to a new study
in the October issue of Liver Transplantation, a journal by John Wiley
& Sons. The article is also available online at Wiley Interscience
(http://www.interscience.wiley.com/).

Transplantation, and subsequent immunosuppression which keeps
rejection at bay, have long been associated with increased cancer
risk. Several studies have examined the issue, but few have used a
control population for comparison, and many rely on limited data. More
studies are needed to reliably reveal the cancer risk pattern after
transplantation, so doctors can optimize immunosuppression, cancer
surveillance and risk management.

Researchers, led by Helena Isoniemi of Finland , sought to describe
the cancer risk pattern in Finnish liver transplant patients,
hypothesizing that the incidence of specific types of cancer would be
higher among the recipients. They included all liver transplant
patients from Helsinki University Central Hospital transplanted
between 1982 and 2005. Using the Finnish Population Register and the
national Cancer Registry, they were able to follow-up on each patient
beginning at the date of transplant through the end of 2005.

Among the 540 liver transplant recipients, they found a total of 39
post-transplant de novo cancers in 36 patients. The overall
standardized incidence ratio (SIR) compared to the general population
was 2.59. Non-Hodgkin lymphoma, non-melanoma skin cancer and basal
cell carcinoma had significantly elevated SIRs.

"The most common cancer types in our cohort were lymphoma and skin
cancer," the authors report. "Non-Hodgkin lymphoma, which included
four cases of post-transplant lymphoproliverative disorder, occurred
more frequently in males, in patients transplanted at a younger age
and soon after transplantation." By contrast, non-melanoma skin cancer
was more common among older patients and those who had antibody
induction therapy. Interestingly, the authors found lower cancer
incidence among patients with history of acute rejections, correlating
most strongly with lymphomas.

"Based on our data, one out of six liver transplant patients is
estimated to develop some form of cancer by 20 years after
transplantation." The authors report. "This study points out the
importance of cancer surveillance after liver transplantation."

An accompanying editorial by Ashokkumar Jain of the University of
Rochester et. al. reviews the Aberg et al findings alongside the rest
of the literature, looking closely at patient age and duration of
follow-up. Aberg and colleagues "show that the cumulative incidence of
de novo cancers increased at 1, 5, 10 and 20 years of follow up from 3
percent, 5 percent, 13 percent and 16 percent respectively," Jain
writes.

He also pointed out that other reports have noted a significantly
increased risk of de novo oropharyngeal and lung cancers amongst liver
transplant patients that smoke, which is a potentially preventable
condition.

Throughout the literature, Jain and his coauthors found wide variation
in the reported incidence of post transplant cancers, partly related
to the length of follow up and partly related to the inclusion or
exclusion of lymphoid lesions.

"The overall rate of de novo solid tumors increased with age at the
time of transplant and the length of follow up; while the rate of post-
transplant lympho-proliferative disorders decreased with age at the
liver transplant, with a higher incidence in the first few years,"
they conclude.

----------------------------
Article adapted by Medical News Today from original press release.
----------------------------

Source: Sean Wagner
Wiley-Blackwell


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > heh heh - as if.
>
> > Let me explainify your math problem for you.
>
> > The average human has a brain weighing 1350 grams.
>
> > You have a brain weight weighing a mere 50 grams (ok, I'm being generous -
> > that's just the way I am - but it will serve this illustration).
>
> > You may then believe your brain is 2700 percent lighter than the average
> > human.
>
> > But you would be wrong. Again. No surprise to anyone but you.
>
> > You can be thankful your brain is simply 96 percent lighter.
>
> > If you still don't get it, have a third grader help you with it...- Hide quoted text -
>
> - Show quoted text -

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