Test,test,test General and Abdominal Adiposity and Risk of Death in Europe
in [Diabetes]
|
Prev: Daily Spirit-guided health tip for 11/13/08
Next: wholesale timberland boot wholesale prada LV sneakers wholesale ed hardy hoody wholesale christian audigier hoody polo tshirts
From: GysdeJongh on 13 Nov 2008 14:58 Do you belong to a special minority ? Do your inherited genes alow you to eat what you want ? Is a BMI above 25 no problem for you ? Can you live with zero exercise ? All important questions.... Now you can test for yourself... Don't believe anybody..... Believe your meter !!! Test, test , test First thing in the morning : Get out of bed Go to the bathroom Stand on your scale Dive the number in kg by your length in m twice Measure your waist Look up your BMI and waist in the tables in the (free :) article below If it's too high increase your exercise, or change it too Low-Boring and high intensity Test, test, test http://content.nejm.org/cgi/content/abstract/359/20/2105 General and Abdominal Adiposity and Risk of Death in Europe ABSTRACT Background Previous studies have relied predominantly on the body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity with the risk of death, but few have examined whether the distribution of body fat contributes to the prediction of death. Methods We examined the association of BMI, waist circumference, and waist-to-hip ratio with the risk of death among 359,387 participants from nine countries in the European Prospective Investigation into Cancer and Nutrition (EPIC). We used a Cox regression analysis, with age as the time variable, and stratified the models according to study center and age at recruitment, with further adjustment for educational level, smoking status, alcohol consumption, physical activity, and height. Results During a mean follow-up of 9.7 years, 14,723 participants died. The lowest risks of death related to BMI were observed at a BMI of 25.3 for men and 24.3 for women. After adjustment for BMI, waist circumference and waist-to-hip ratio were strongly associated with the risk of death. Relative risks among men and women in the highest quintile of waist circumference were 2.05 (95% confidence interval [CI], 1.80 to 2.33) and 1.78 (95% CI, 1.56 to 2.04), respectively, and in the highest quintile of waist-to-hip ratio, the relative risks were 1.68 (95% CI, 1.53 to 1.84) and 1.51 (95% CI, 1.37 to 1.66), respectively. BMI remained significantly associated with the risk of death in models that included waist circumference or waist-to-hip ratio (P<0.001). Conclusions These data suggest that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio in addition to BMI in assessing the risk of death. hth Gys
From: jay on 13 Nov 2008 16:49 > Conclusion: These data suggest that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio in addition to BMI in assessing the risk of death. Above association may be linked to environmental pollutants since they tend to be lipophilic and get stored in fatty tissues such as adipose. See below. > Test, test, test ... In addition, avoid ingesting, breathing and contacting pollutants. Animal based dietary fat is the most common source. ----------------- White adipose tissue: storage and effector site for environmental pollutants. White adipose tissue (WAT) represents a reservoir of lipophilic environmental pollutants, especially of those which are resistant to biological and chemical degradation - so-called persistent organic pollutants (POPs). Large amounts of different congeners and isomers of these compounds exhibit a variety of adverse biological effects. Interactions among different classes of compounds, frequently with opposing effects, complicate hazard evaluation and risk assessment. WAT is the key organ for energy homeostasis and it also releases metabolites into the circulation and adipokines with systemic effects on insulin sensitivity and fuel partitioning in muscles and other tissues. Its beneficial role is lost in obesity when excessive accumulation of WAT contributes to severe diseases, such as diabetes. POPs may crossroad or modulate the effect of endogenous ligands of nuclear transcription factors, participating in differentiation, metabolism and the secretory function of adipocytes. These mechanisms include, most importantly: i) endocrine disrupting potency of POPs mixtures on androgen, estrogen or thyroid hormone metabolism/functions in WAT, ii) interference of dioxin-like chemicals with retinoic acid homeostasis, where impact on retinoid receptors is expected, and iii) interaction with transcriptional activity of peroxisome proliferator- activated receptors is likely. Thus, the accumulation and action of POPs in WAT represents a unitary mechanism explaining, at least in part, the effects of POPs in the whole organism. By modulating WAT differentiation, metabolism and function, the POPs could affect not only the physiological role of WAT, but they may also influence the development of obesity-associated diseases. PMID: 16925464 ----------------- Common Mito Toxins Metals Mercury (fish, analgams) Aluminum (cooking ware) Arsenic Cadmium Lead Manganese Fluoride (city water) Thallium Pesticides Organochlorines: DDT, lindane, chlordane, endrin, etc. Organophosphates: parathion, etc. DEET Pyrethroids Rotenone Herbicides Paraquat PCBs Dioxin PAH and PM Smoking Vehicle exhaust Ethanol, Toluene, Benzene Trans fatty acids Hydrogenated oils Drugs H2-receptor antagonist, cimetidine, ranitidine Antibiotics, chloramphenicol, tetracyclines Phthalates (plasticizers)
From: Andrew B. Chung, MD/PhD on 13 Nov 2008 21:48 jay wrote: > > > Conclusion: These data suggest that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio in addition to BMI in assessing the risk of death. > > Above association may be linked to environmental pollutants since they > tend to be lipophilic and get stored in fatty tissues such as adipose. > See below. > > > Test, test, test ... > > In addition, avoid ingesting, breathing and contacting pollutants. > Animal based dietary fat is the most common source. > > ----------------- > White adipose tissue: storage and effector site for environmental > pollutants. > White adipose tissue (WAT) represents a reservoir of lipophilic > environmental pollutants, especially of those which are resistant to > biological and chemical degradation - so-called persistent organic > pollutants (POPs). Large amounts of different congeners and isomers of > these compounds exhibit a variety of adverse biological effects. > Interactions among different classes of compounds, frequently with > opposing effects, complicate hazard evaluation and risk assessment. > WAT is the key organ for energy homeostasis and it also releases > metabolites into the circulation and adipokines with systemic effects > on insulin sensitivity and fuel partitioning in muscles and other > tissues. Its beneficial role is lost in obesity when excessive > accumulation of WAT contributes to severe diseases, such as diabetes. > POPs may crossroad or modulate the effect of endogenous ligands of > nuclear transcription factors, participating in differentiation, > metabolism and the secretory function of adipocytes. These mechanisms > include, most importantly: i) endocrine disrupting potency of POPs > mixtures on androgen, estrogen or thyroid hormone metabolism/functions > in WAT, ii) interference of dioxin-like chemicals with retinoic acid > homeostasis, where impact on retinoid receptors is expected, and iii) > interaction with transcriptional activity of peroxisome proliferator- > activated receptors is likely. Thus, the accumulation and action of > POPs in WAT represents a unitary mechanism explaining, at least in > part, the effects of POPs in the whole organism. By modulating WAT > differentiation, metabolism and function, the POPs could affect not > only the physiological role of WAT, but they may also influence the > development of obesity-associated diseases. PMID: 16925464 > > ----------------- > Common Mito Toxins > > Metals > Mercury (fish, analgams) > Aluminum (cooking ware) > Arsenic > Cadmium > Lead > Manganese > Fluoride (city water) > Thallium > Pesticides > Organochlorines: DDT, lindane, chlordane, endrin, etc. > Organophosphates: parathion, etc. > DEET > Pyrethroids > Rotenone > Herbicides > Paraquat > PCBs > Dioxin > PAH and PM > Smoking > Vehicle exhaust > Ethanol, Toluene, Benzene > Trans fatty acids > Hydrogenated oils > Drugs > H2-receptor antagonist, cimetidine, ranitidine > Antibiotics, chloramphenicol, tetracyclines > Phthalates (plasticizers) It remains wiser to simply eat less, down to the right amount: http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17?
From: Chris Malcolm on 19 Nov 2008 07:43 GysdeJongh <jongh711(a)planet.nl> wrote: > Do you belong to a special minority ? > Do your inherited genes alow you to eat what you want ? > Is a BMI above 25 no problem for you ? > Can you live with zero exercise ? > All important questions.... > Now you can test for yourself... > Don't believe anybody..... > Believe your meter !!! > Test, test , test > First thing in the morning : > Get out of bed > Go to the bathroom > Stand on your scale > Dive the number in kg by your length in m twice > Measure your waist > Look up your BMI and waist in the tables in the (free :) article below > If it's too high increase your exercise, or change it too Low-Boring and > high intensity > Test, test, test > http://content.nejm.org/cgi/content/abstract/359/20/2105 > General and Abdominal Adiposity and Risk of Death in Europe [snip to conclusion] > Conclusions These data suggest that both general adiposity and abdominal > adiposity are associated with the risk of death and support the use of waist > circumference or waist-to-hip ratio in addition to BMI in assessing the risk > of death. I agree. Since I already log my weight every time I take a bath, but I'm possibly confusing the issue of weight by developing muscle mass, I picked up a cheap second hand pair of large measuring callipers at my local tool shop the other day. Now in addition to running a tape round my waist, I'll be able to measure some skin fat pinches and muscle sizes. I find keeping such logs helps to motivate me to keep up the exercising and keep down the snacks :-) -- Chris Malcolm
From: Nicky on 19 Nov 2008 16:03
On 19 Nov 2008 12:43:45 GMT, Chris Malcolm <cam(a)holyrood.ed.ac.uk> wrote: >I agree. Since I already log my weight every time I take a bath, but >I'm possibly confusing the issue of weight by developing muscle mass, >I picked up a cheap second hand pair of large measuring callipers at >my local tool shop the other day. Now in addition to running a tape >round my waist, I'll be able to measure some skin fat pinches and >muscle sizes. I find keeping such logs helps to motivate me to keep up >the exercising and keep down the snacks :-) Using a pair of calipers correctly is supposed to be beyond us mortals, without Proper Training... how are you doing it, Chris? It's never occurred to me to go and buy my own! Nicky. T2 dx 05/04 + underactive thyroid D&E, 100ug thyroxine Last A1c 5.4% BMI 25 |