Stimulants vs reuptake inhibitors?
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From: John on 24 Jun 2008 17:37 Hi, I just wonder if there is any difference in the effect you get from stimulants (i.e. medications directly acting as a certain neurontansmitter or on a certain receptor) vs reuptake inhibitors (i.e. medications inhibiting the reuptake of neurotransmitters produced by the body itself, thereby increasing the amount available at the synapse)? Could it for example be that only stimulants will work in cases where there is extremely low neurotransmitterlevels in parts of the brain, so that there is really nothing to inhibit reuptake of so to speak? Also, is there any difference in the chance of developing tolerance between the two working mechanisms? Thanks! ** Posted from http://www.teranews.com **
From: Nom dePlume on 24 Jun 2008 23:55 "John" <nospam(a)no.where> wrote in message news:80269$4861690f$12647(a)news.teranews.com... > Hi, > > I just wonder if there is any difference in the effect you get from > stimulants (i.e. medications directly acting as a certain neurontansmitter > or on a certain receptor) vs reuptake inhibitors (i.e. medications > inhibiting the reuptake of neurotransmitters produced by the body itself, > thereby increasing the amount available at the synapse)? Could it for > example be that only stimulants will work in cases where there is > extremely low neurotransmitterlevels in parts of the brain, so that there > is really nothing to inhibit reuptake of so to speak? Also, is there any > difference in the chance of developing tolerance between the two working > mechanisms? > > Thanks! Yes, they are quite different. First, SSRIs affect serotonin, while stimulants affect dopamine and norepinephrine, so the effects of the two are very different. A closer comparison would be between antidepressants that increase dopamine and norepinephrine concentration (Wellbutrin, Selegiline) and stimulants. Both categories are "stimulating," meaning they boost energy, can improve concentration, and can improve mood (especially anhedonia), either singly, or in combination with an SSRI. However, stimulants can be addictive, and lead to tolerance, while dopamine and norepinephrine reuptake inhibitors are less prone to causing tolerance (and are not addictive). There are cases where people have exhausted everything except stimulants, and then found stimulants to relieve depression. No one know why this is so, but my best guess is just what you have described: Neurons are malfunctioning by not release dopamine and norepinephrine as fast as they should. I talk about these subjects in my book, and on my Web site, if you'd like to read more about them. -- Nom dePlume, Ph.D. Why, yes, in fact, I am a rocket scientist. Find my book, Medicines for Mental health, and free drug information, at www.MentalMeds.org =====
From: vauxall on 25 Jun 2008 11:44 x-no-archive:yes On Jun 24, 10:37 pm, "John" <nos...(a)no.where> wrote: > Hi, > > I just wonder if there is any difference in the effect you get from > stimulants (i.e. medications directly acting as a certain neurontansmitter > or on a certain receptor) vs reuptake inhibitors (i.e. medications > inhibiting the reuptake of neurotransmitters produced by the body itself, > thereby increasing the amount available at the synapse)? Interesting question, of course there's a difference and this has been pointed out. According to the late David Horrobin, both approaches are wrong. He claimes that mental health disease must and can be resolved at the phospholipidic layer and not at the synaptic (read: neurotrasmitter) level, hence the suggestion of curing depression and shizophrenia with EPA fish oils: http://www.ncbi.nlm.nih.gov/pubmed/9543204
From: George Orwell on 25 Jun 2008 19:04 Nom dePlume wrote: > I talk about these subjects in my book, and on my Web site, > if you'd like to read more about them. Read about it here: Essential Psychopharmacology, The Prescriber's Guide, Revised and Updated Edition by Stephen M. Stahl, M.D., Ph.D. http://tinyurl.com/3oknug Il mittente di questo messaggio|The sender address of this non corrisponde ad un utente |message is not related to a real reale ma all'indirizzo fittizio|person but to a fake address of an di un sistema anonimizzatore |anonymous system Per maggiori informazioni |For more info https://www.mixmaster.it
From: kylemeister on 28 Jun 2008 13:56
The OP appears to be asking about the difference between agonists and reuptake inhibitors, not between stimulants and reuptake inhibitors (nor indeed between stimulants and SSRIs). |