From: Kumar on
Hello,

I am trying to better understand about stem cells activities related
to immune status. I read about following issue:-

"4. Cortisone (steroid) or non-steroidal anti-inflammatories do not
belong anywhere in the treatment process. Their use will inhibit
engraftment and mask any adverse events. This will lead to a failed
response to the treatment. Stem cells rely on inflammation to guide
their homing and this is switched off by any anti-inflammatory -
resulting in no treatment response.

5. Multiple invasive procedures confer no extra benefit, and lead to
higher risk of contamination, infection and results in greater trauma
and therefore less response to therapy. The reason for the lesser
response is that trauma is inflammation and attracts stem cells, which
are wasted on the damage caused, and not on the disease the patient
wanted treatment for in the first place. In addition, repeated lumbar
punctures can lead to long-term back pain.
http://www.regenecell.com/article-guidelines-for-stem-cell-therapy.htm
"

Is it true that medical interventions by anti-inflammatory durgs &
steriods can interfere in normal defence activities by stem cells?

Will you tell me more about stem cells relevance with status of immune
defence response? Can stem cells normal activities be compromised or
weakened causing weak defence responses & abnormal healing?

Best wishes.


From: N on
On 31 May, 10:58, Kumar <lordshiva5...(a)gmail.com> wrote:
> Hello,
>
> I am trying to better understand about stem cells activities related
> to immune status. I read about following issue:-
>
> "4. Cortisone (steroid) or non-steroidal anti-inflammatories do not
> belong anywhere in the treatment process. Their use will inhibit
> engraftment and mask any adverse events. This will lead to a failed
> response to the treatment. Stem cells rely on inflammation to guide
> their homing and this is switched off by any anti-inflammatory -
> resulting in no treatment response.
>
> 5. Multiple invasive procedures confer no extra benefit, and lead to
> higher risk of contamination, infection and results in greater trauma
> and therefore less response to therapy. The reason for the lesser
> response is that trauma is inflammation and attracts stem cells, which
> are wasted on the damage caused, and not on the disease the patient
> wanted treatment for in the first place. In addition, repeated lumbar
> punctures can lead to long-term back pain.http://www.regenecell.com/article-guidelines-for-stem-cell-therapy.htm
> "
>
> Is it true that medical interventions by anti-inflammatory durgs &
> steriods can interfere in normal defence activities by stem cells?
>
> Will you tell me more about stem cells relevance with status of immune
> defence response? Can stem cells normal activities be compromised or
> weakened causing weak defence responses & abnormal healing?
>
> Best wishes.

dentists appointment
From: Kumar on
On May 31, 8:54 pm, N <n.m.ke...(a)hotmail.co.uk> wrote:
> On 31 May, 10:58, Kumar <lordshiva5...(a)gmail.com> wrote:
>
>
>
>
>
> > Hello,
>
> > I am trying to better understand about stem cells activities related
> > to immune status. I read about following issue:-
>
> > "4. Cortisone (steroid) or non-steroidal anti-inflammatories do not
> > belong anywhere in the treatment process. Their use will inhibit
> > engraftment and mask any adverse events. This will lead to a failed
> > response to the treatment. Stem cells rely on inflammation to guide
> > their homing and this is switched off by any anti-inflammatory -
> > resulting in no treatment response.
>
> > 5. Multiple invasive procedures confer no extra benefit, and lead to
> > higher risk of contamination, infection and results in greater trauma
> > and therefore less response to therapy. The reason for the lesser
> > response is that trauma is inflammation and attracts stem cells, which
> > are wasted on the damage caused, and not on the disease the patient
> > wanted treatment for in the first place. In addition, repeated lumbar
> > punctures can lead to long-term back pain.http://www.regenecell.com/article-guidelines-for-stem-cell-therapy.htm
> > "
>
> > Is it true that medical interventions by anti-inflammatory durgs &
> > steriods can interfere in normal defence activities by stem cells?
>
> > Will you tell me more about stem cells relevance with status of immune
> > defence response? Can stem cells normal activities be compromised or
> > weakened causing weak defence responses & abnormal healing?
>
> > Best wishes.
>
> dentists appointment- Hide quoted text -
>
> - Show quoted text -

What do you want to tell?
From: Kumar on
On Jun 1, 7:45 am, Kumar <lordshiva5...(a)gmail.com> wrote:
> On May 31, 8:54 pm, N <n.m.ke...(a)hotmail.co.uk> wrote:
>
>
>
>
>
> > On 31 May, 10:58, Kumar <lordshiva5...(a)gmail.com> wrote:
>
> > > Hello,
>
> > > I am trying to better understand about stem cells activities related
> > > to immune status. I read about following issue:-
>
> > > "4. Cortisone (steroid) or non-steroidal anti-inflammatories do not
> > > belong anywhere in the treatment process. Their use will inhibit
> > > engraftment and mask any adverse events. This will lead to a failed
> > > response to the treatment. Stem cells rely on inflammation to guide
> > > their homing and this is switched off by any anti-inflammatory -
> > > resulting in no treatment response.
>
> > > 5. Multiple invasive procedures confer no extra benefit, and lead to
> > > higher risk of contamination, infection and results in greater trauma
> > > and therefore less response to therapy. The reason for the lesser
> > > response is that trauma is inflammation and attracts stem cells, which
> > > are wasted on the damage caused, and not on the disease the patient
> > > wanted treatment for in the first place. In addition, repeated lumbar
> > > punctures can lead to long-term back pain.http://www.regenecell.com/article-guidelines-for-stem-cell-therapy.htm
> > > "
>
> > > Is it true that medical interventions by anti-inflammatory durgs &
> > > steriods can interfere in normal defence activities by stem cells?
>
> > > Will you tell me more about stem cells relevance with status of immune
> > > defence response? Can stem cells normal activities be compromised or
> > > weakened causing weak defence responses & abnormal healing?
>
> > > Best wishes.
>
> > dentists appointment- Hide quoted text -
>
> > - Show quoted text -
>
> What do you want to tell?- Hide quoted text -
>
> - Show quoted text -

I can't say if anti-oxidants can also act as antiinflammatorys in this
regard.
It can be important to understand that if immuno-compromise,
immunodefficiency, scar formations, delayed & abnormal healings are
related stem cells decreased activities. So it can be interesting to
understand stem cells weakness & immobilization.
From: Kofi on
> Is it true that medical interventions by anti-inflammatory durgs &
> steriods can interfere in normal defence activities by stem cells?

Yes. There are probably a host of different interventions that could
interfere with the complement cascade. Vitamin D and growth hormone are
two other factors with which you should not interfere.

> Will you tell me more about stem cells relevance with status of immune
> defence response?

Are you asking what repeated harvesting from bone marrow will do or are
you asking about stem cell procedures that restore immunity?

Sometimes in colitis, the body develops an antibody against an important
component in macrophage function (IL-10 or GM-CSF). The result can be
chronic inflammation in the gut which can be healed with PRP -
platelet-rich prolotherapy - which essentially draws stem cells to the
site of a wound more effectively. It's also the case that certain stem
cell treatments can lead to a suppression of autoimmunity which, for
instance, could resolve macrophage dysfunction in a case of colitis.

> Can stem cells normal activities be compromised or
> weakened causing weak defence responses & abnormal healing?

My modeling indicates it can. For instance, cathelicidin is important
in both preventing infection and mobilizing stem cells. Anything that
interferes with it - like TNF-alpha or high iron consumption - probably
would damage some repair component like angiogenesis while inhibiting
immune response (like through TLR2).