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From: jay on 4 Apr 2008 19:41
> ... Also meriting consideration is the allergenic response
> that may sometimes occur in humans, as well as calves
> and piglets, on dietary exposure to soybeans.

A Soy Diet Accelerates Renal Damage in Autoimmune MRL/Mp-lpr/lpr Mice.

Isoflavones, which are phytoestrogens present in large quantities in
soy and soy-derived products, have estrogenic activity, inhibit
protein tyrosine kinase, and exert other effects in the human body.
Thus, the recent spread of soy consumption in Western populations
emphasizes the need to more fully understand the potential effects in
the body, especially in abnormal immune conditions. In the present
study, the influence of a soy diet on lupus disease in MRL/Mp-lpr/lpr
(MRL/lpr) mice was investigated. Weanling female MRL/lpr mice (4
weeks) were fed a soy diet (20% soybean protein and 5% soybean oil).
The soy diet exacerbated renal damage; findings in this mouse strain
included accelerated proteinuria, elevated serum creatinine
concentrations, and reduced creatinine clearance. No effects were
detected, however, in C3H/HeN mice, which have the same H-2(k) genetic
background as MRL/lpr mice do. A tendency toward an increase in thymus
weight and proliferation of T cells in spleen and B cells in lymph
nodes were found at the age of 16 weeks. These findings indicate that
a soy diet, in comparison with a casein diet, significantly
exacerbates the clinical course of this autoimmune disease. Further
research on the mechanism of this effect of soy-rich diets is needed,
and isoflavone supplementation for systemic lupus erythematosus
patients should be carefully reevaluated.

PMID: 16039550
From: ironjustice on 4 Apr 2008 23:05
On Apr 4, 4:41 pm, jay <jaym1...(a)hotmail.com> wrote: A Soy Diet
Accelerates Renal Damage in Autoimmune MRL/Mp-lpr/lpr Mice. <<

What kind of mice were those .. again .. ?

"Isoflavone supplementation for systemic lupus erythematosus patients
should be carefully reevaluated"

Oh .. they are trying to get the present supplementation IN ..
lupus .. repealed .. ?

They concluded they have to reevaluate the supplementation of ..
isofavones .. ?

That's too .. bad.

They have some work ahead of them ..

I bet you wish them the .. best .. don't ya .. jay ..

Heh .. heh ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> > ... Also meriting consideration is the allergenic response
> > that may sometimes occur in humans, as well as calves
> > and piglets, on dietary exposure to soybeans.
>
> A Soy Diet Accelerates Renal Damage in Autoimmune MRL/Mp-lpr/lpr Mice.
>
> Isoflavones, which are phytoestrogens present in large quantities in
> soy and soy-derived products, have estrogenic activity, inhibit
> protein tyrosine kinase, and exert other effects in the human body.
> Thus, the recent spread of soy consumption in Western populations
> emphasizes the need to more fully understand the potential effects in
> the body, especially in abnormal immune conditions. In the present
> study, the influence of a soy diet on lupus disease in MRL/Mp-lpr/lpr
> (MRL/lpr) mice was investigated. Weanling female MRL/lpr mice (4
> weeks) were fed a soy diet (20% soybean protein and 5% soybean oil).
> The soy diet exacerbated renal damage; findings in this mouse strain
> included accelerated proteinuria, elevated serum creatinine
> concentrations, and reduced creatinine clearance. No effects were
> detected, however, in C3H/HeN mice, which have the same H-2(k) genetic
> background as MRL/lpr mice do. A tendency toward an increase in thymus
> weight and proliferation of T cells in spleen and B cells in lymph
> nodes were found at the age of 16 weeks. These findings indicate that
> a soy diet, in comparison with a casein diet, significantly
> exacerbates the clinical course of this autoimmune disease. Further
> research on the mechanism of this effect of soy-rich diets is needed,
> and isoflavone supplementation for systemic lupus erythematosus
> patients should be carefully reevaluated.
>
> PMID: 16039550

From: ironjustice on 4 Apr 2008 23:40
On Apr 4, 8:05 pm, ironjustice <teamtan...(a)hotmail.com> wrote:
isoflavones <<

Contrary it seems to .. "Isoflavones kill you .. !!"

"We recommend to use them in our diet as a good source of
isoflavones."

It 'may' be because isoflavones 'may' kill .. cancer .. ?

"Cell proliferation is significantly inhibited by potential
phytoestrogens isolated from rye, green and yellow pea seeds "
"It is proposed that green and yellow pea seeds contain measurable
concentrations of isoflavones and rye seeds contain lignans which can
be isolated and used for special human diet programs."

Titre du document / Document title
Effects of phytoestrogen extracts isolated from rye, green and yellow
pea seeds on hormone production and proliferation of trophoblast tumor
cells Jeg3
Auteur(s) / Author(s)
MATSCHESKI A. ; RICHTER D.-U. ; HARTMANN A.-M. ; EFFMERT U. ; JESCHKE
U. ; KUPKA M. S. ; ABARZUA S. ; BRIESE V. ; RUTH W. ; KRAGL U. ;
PIECHULLA B. ;
Résumé / Abstract
Background:
Phytoestrogens are a diverse group of non-steroidal plant compounds.
Because they have chemical structures similar to estrogens they are
able to bind on estrogen receptors in humans. Objectives:
In this study, we tested the effects of crude phytoestrogen extracts
from rye (Secale cereale), green pea (Pisum sativum) and yellow pea
seeds (Pisum sativum cv.) on cell proliferation and the production of
progesterone in trophoblast tumor cells of the cell line Jeg3.
Methods:
Isoflavone extracts from green and yellow pea seeds and lignan
extracts from rye seeds were obtained, using different extraction
methods. Isolated extracts were incubated in different concentrations
with trophoblast tumor cells.
Untreated cells were used as controls.
At designated times, aliquots were removed and tested for estradiol
and progesterone production.
In addition, we tested the effects of the phytoestrogen extracts on
cell proliferation.
Results:
Cell proliferation is significantly inhibited by potential
phytoestrogens isolated from rye, green and yellow pea seeds in
trophoblast tumor cells of the cell line Jeg3.
We found a correlation between the effects of proliferation and
production of estradiol in isoflavone extracts from green and yellow
pea seeds in Jeg3 cells.
In addition, higher concentrations of isoflavones isolated from green
pea seeds and lignans from rye showed also a inhibition of
progesterone production whereas higher concentrations of rye lignans
elevated estradiol production in Jeg3 cells.
Conclusion:
A useful indicator test system for potential phytoestrogens could be
established.
Based on the obtained results it is proposed that green and yellow pea
seeds contain measurable concentrations of isoflavones and rye seeds
contain lignans which can be isolated and used for special human diet
programs.
Revue / Journal Title
Hormone research ISSN 0301-0163 CODEN HRMRA3
Source / Source
2006, vol. 65, no6, pp. 276-288 [13 page(s) (article)]
Langue / Language
Anglais

Editeur / Publisher
Karger, Basel, SUISSE (1973) (Revue)

Mots-clés d'auteur / Author Keywords
Jeg3 ; Rye ; Green and yellow pea ; Estradiol ; Progesterone ; 5-
Bromo-2'-deoxy-Uridine ;
Localisation / Location
INIST-CNRS, Cote INIST : 14766, 35400015668412.0030


Copyright 2007 INIST-CNRS. All rights reserved

Toute reproduction ou diffusion même partielle, par quelque procédé ou
sur tout support que ce soit, ne pourra être faite sans l'accord
préalable écrit de l'INIST-CNRS.
No part of these records may be reproduced of distributed, in any form
or by any means, without the prior written permission of INIST-CNRS.

Nº notice refdoc (ud4) : 17830924

-------------------------------

"We recommend to use them in our diet as a good source of
isoflavones."

Published online 1 March 2007
Published in Crop Sci 47:717-719 (2007)
© 2007 Crop Science Society of America
677 S. Segoe Rd., Madison, WI 53711 USA This Article


CROP PHYSIOLOGY & METABOLISM
Production of Isoflavones in Seeds and Seedlings of Different Peanut
Genotypes
Ara Kirakosyana, Peter B. Kaufmana,*, James A. Dukeb, E. Mitchell
Seymoura, Sara Warbera and Steven F. Bollinga
a Univ. of Michigan Integrative Medicine Program (MIM), Univ. of
Michigan, Ann Arbor, MI 48109
b Herbal Vineyard, 8210 Murphy Rd., Fulton, MD 20759

* Corresponding author (pbk(a)umich.edu).

The present study compares concentrations of medicinally important
isoflavones in seeds versus seedlings of 20 selected peanut genotypes
derived from widely different geographic sources and compares the
total isoflavone concentrations in peanut (Arachis hypogaea L.) with
those present in soybean [Glycine max (L.) Merr.] and kudzu [Pueraria
montana (Lour.) Merr.]. Results of analyses of 20 different peanut
genotypes showed that wide variation occurs in isoflavone
concentrations both in peanut seeds and peanut seedlings; that peanut
seedlings possess 0.8-fold to 27-fold higher concentrations of
isoflavones than peanut seeds; that peanut seeds and seedlings possess
little or no genistein; that peanut seeds contain one-half the
concentrations of isoflavones as soybean seeds, and soybean seedlings
contain four times higher concentrations of isoflavones than peanut
seedlings; and that kudzu seeds and seedlings, in contrast, contain
significantly higher concentrations of isoflavones than either peanut
or soybean seeds and seedlings. In conclusion, because peanut
seedlings and sprouts are better sources of isoflavones than peanut
seeds, we recommend that the former be grown as a vegetable so as to
use them in our diet as a good source of isoflavones. Furthermore, the
wide variation in isoflavone concentrations in different peanut
genotypes, as shown in this study, could be exploited by plant
breeders as an easy and reasonable production strategy.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> On Apr 4, 4:41 pm, jay <jaym1...(a)hotmail.com> wrote: A Soy Diet
> Accelerates Renal Damage in Autoimmune MRL/Mp-lpr/lpr Mice. <<
>
> What kind of mice were those .. again .. ?
>
> "Isoflavone supplementation for systemic lupus erythematosus patients
> should be carefully reevaluated"
>
> Oh .. they are trying to get the present supplementation IN ..
> lupus .. repealed .. ?
>
> They concluded they have to reevaluate the supplementation of ..
> isofavones .. ?
>
> That's too .. bad.
>
> They have some work ahead of them ..
>
> I bet you wish them the .. best .. don't ya .. jay ..
>
> Heh .. heh ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > > ... Also meriting consideration is the allergenic response
> > > that may sometimes occur in humans, as well as calves
> > > and piglets, on dietary exposure to soybeans.
>
> > A Soy Diet Accelerates Renal Damage in Autoimmune MRL/Mp-lpr/lpr Mice.
>
> > Isoflavones, which are phytoestrogens present in large quantities in
> > soy and soy-derived products, have estrogenic activity, inhibit
> > protein tyrosine kinase, and exert other effects in the human body.
> > Thus, the recent spread of soy consumption in Western populations
> > emphasizes the need to more fully understand the potential effects in
> > the body, especially in abnormal immune conditions. In the present
> > study, the influence of a soy diet on lupus disease in MRL/Mp-lpr/lpr
> > (MRL/lpr) mice was investigated. Weanling female MRL/lpr mice (4
> > weeks) were fed a soy diet (20% soybean protein and 5% soybean oil).
> > The soy diet exacerbated renal damage; findings in this mouse strain
> > included accelerated proteinuria, elevated serum creatinine
> > concentrations, and reduced creatinine clearance. No effects were
> > detected, however, in C3H/HeN mice, which have the same H-2(k) genetic
> > background as MRL/lpr mice do. A tendency toward an increase in thymus
> > weight and proliferation of T cells in spleen and B cells in lymph
> > nodes were found at the age of 16 weeks. These findings indicate that
> > a soy diet, in comparison with a casein diet, significantly
> > exacerbates the clinical course of this autoimmune disease. Further
> > research on the mechanism of this effect of soy-rich diets is needed,
> > and isoflavone supplementation for systemic lupus erythematosus
> > patients should be carefully reevaluated.
>
> > PMID: 16039550- Hide quoted text -
>
> - Show quoted text -

From: ironjustice on 5 Apr 2008 00:01
On Apr 4, 8:40 pm, ironjustice <teamtan...(a)hotmail.com> wrote:
isoflavones <<

http://www.isoflavones.info/isoflavones-safety.php

Safety of isoflavones
There are studies which try to prove that isoflavones are not safe.
These studies are mostly based on experiments with animals and studies
in-vitro (where tests are done in cells grown in test tubes). The
interpretation of these results and the extrapolations to humans is
questionable. Most of the isoflavones dosages which were used are very
high compared with normal usage. The following issues are often
raised:


Isoflavones can cause breast cancer
Isoflavones are similar in structures as human estrogen. Therefore
it's easy to make the theory that isoflavones are not safe for women
with a cancer breast risk.
Test with Raloxifene, a molecule similar to isoflavones, proved that
they protect against breast cancer. Animal studies also show that
fermented soyfood, miso or soy protein significantly improve the
chemotherapeutic effects of Tamoxifen.
In a in-vitro study the isoflavones genistein inhibited the growth of
breast cancer cells. Genistein had a synergistic effect with
tamoxifen.
Based on the currently available evidence there's no reason that
consuming soy may cause breast cancer. With isoflavones supplements
it's easy to take too much isoflavones, which is not possible when
consuming soyfoods. Not much data is available on the overconsumption
of isoflavones supplements. It's recommended not to consume more tan
50 mg isoflavones as supplement per day.


Isoflavones and infant development
In the United States, about 20 percent of the infants are given soy
formulas. It has been suggested soy formula could accelerate puberty
and cause developmental and reproductive abnormalities and thyroid
disorders. Preliminary research in the US found that isoflavones of
soy infant formula do not disrupt infant development, despite concerns
from some scientists that the isoflavones could act like female
hormones in infants. Studies at the Arkansas Children's Nutrition
Center have found no apparent long-term positive or negative effects
of feeding infants soy versus cow's milk formula.
Ryowon C. et al investigated the effects of soy isoflavones on babies
and concluded that soy-based formula could be used for long-term
feeding of babies.


Adverse effects on boys or men
Because isoflavones are similar in structure than the 'female' hormone
estrogen some people are very quick to make a link between isoflavones
and development of breasts and adverse effect on fertility of boys and
men. However, animal studies did not find any change in fertility.
Studies on men taking isoflavones supplements showed no effect on
plasma hormones or semen quality. Other studies showed no adverse
effects on sperm quality in mice fed with genistein.


Isoflavones and thyroid
The hormones produced by the thyroid are needed for the growth. Soy
appears to have potential effects involving the thyroid gland.
Individuals with impaired thyroid function should discuss the intake
of isoflavones with their phycisian because isoflavones have been
observed to reduce absorption of thyroid medication. Studies have
shown that infants fed with soy formula have the same development as
infants fed with cow milk formula.
Studies showed that soyfoods, and their isoflavones, are associated
with a reduced risk of thyroid cancer. Some studies hint that
isoflavones may inhibit the function of the thyroid gland, though this
inhibition may only be significant in individuals who are deficient in
iodine. Therefore people who consume large amounts of soy or
isoflavones should make sure that their intake of iodine is adequate.
Other studies on healthy humans have found that soy and isoflavones
had no effect on thyroid hormone levels and actually increased levels
in some cases.


More literature about safety of isoflavones
Chang HC et al. Dietary genistein inactivates rat thyroid peroxidase
in vivo without an apparent hypothyroid effect. Toxicol Appl Pharmacol
2000;168(3):244-252.

Cummings SR et al. The effect of Raloxifene on risk of breast cancer
in postmenopausal women: results from the MORE randomized trial. JAMAI
1999;281:2189-2197.

Tanos V et al. Synergistic inhibitory effects of genistein and
tamoxifen on human dysplastic and malignant epithelial breast cells in
vitro. Eur J Obstet Gynecol Repr Biol 2002 May 10;102(2):188-94

Mitchell JH et al. Effect of phytoestrogen food supplement on
reproductive health in normal males. Clin Sci (Lond) 2001 Jun;100(6):
613-618.

Fielden MR et al. Effect of human dietary exposure levels of genistein
during gestation and lactation on long-term reproductive development
and sperm quality in mice. Food Chem Toxicol 2003 Apr;41(4):447-54.

Churella HR et al. Growth and protein status of term infants fed soy
protein formulas differing in protein content. J Am Coll Nutr
1994;13:362-267.

Pamela L et al. Phytoestrogens and thyroid cancer risk among woman.
Presented in the 4th international symposium on the role of soy in
preventing and treating chronic disease, San Diego, CA. 2001 Nov 4-7.

The long term effects of soy-based formula on isoflavone concentration
of plasma and urine, and growth and recognition development at 10 and
20 months old infants. Asia Pac J Clin Nutr. 2004;13(Suppl):S123


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



> On Apr 4, 8:05 pm, ironjustice <teamtan...(a)hotmail.com> wrote:
> isoflavones <<
>
> Contrary it seems to .. "Isoflavones kill you .. !!"
>
> "We recommend to use them in our diet as a good source of
> isoflavones."
>
> It 'may' be because isoflavones 'may' kill .. cancer .. ?
>
> "Cell proliferation is significantly inhibited by potential
> phytoestrogens isolated from rye, green and yellow pea seeds "
> "It is proposed that green and yellow pea seeds contain measurable
> concentrations of isoflavones and rye seeds contain lignans which can
> be isolated and used for special human diet programs."
>
> Titre du document / Document title
> Effects of phytoestrogen extracts isolated from rye, green and yellow
> pea seeds on hormone production and proliferation of trophoblast tumor
> cells Jeg3
> Auteur(s) / Author(s)
> MATSCHESKI A. ; RICHTER D.-U. ; HARTMANN A.-M. ; EFFMERT U. ; JESCHKE
> U. ; KUPKA M. S. ; ABARZUA S. ; BRIESE V. ; RUTH W. ; KRAGL U. ;
> PIECHULLA B. ;
> Résumé / Abstract
> Background:
> Phytoestrogens are a diverse group of non-steroidal plant compounds.
> Because they have chemical structures similar to estrogens they are
> able to bind on estrogen receptors in humans. Objectives:
> In this study, we tested the effects of crude phytoestrogen extracts
> from rye (Secale cereale), green pea (Pisum sativum) and yellow pea
> seeds (Pisum sativum cv.) on cell proliferation and the production of
> progesterone in trophoblast tumor cells of the cell line Jeg3.
> Methods:
> Isoflavone extracts from green and yellow pea seeds and lignan
> extracts from rye seeds were obtained, using different extraction
> methods. Isolated extracts were incubated in different concentrations
> with trophoblast tumor cells.
> Untreated cells were used as controls.
> At designated times, aliquots were removed and tested for estradiol
> and progesterone production.
> In addition, we tested the effects of the phytoestrogen extracts on
> cell proliferation.
> Results:
> Cell proliferation is significantly inhibited by potential
> phytoestrogens isolated from rye, green and yellow pea seeds in
> trophoblast tumor cells of the cell line Jeg3.
> We found a correlation between the effects of proliferation and
> production of estradiol in isoflavone extracts from green and yellow
> pea seeds in Jeg3 cells.
> In addition, higher concentrations of isoflavones isolated from green
> pea seeds and lignans from rye showed also a inhibition of
> progesterone production whereas higher concentrations of rye lignans
> elevated estradiol production in Jeg3 cells.
> Conclusion:
> A useful indicator test system for potential phytoestrogens could be
> established.
> Based on the obtained results it is proposed that green and yellow pea
> seeds contain measurable concentrations of isoflavones and rye seeds
> contain lignans which can be isolated and used for special human diet
> programs.
> Revue / Journal Title
> Hormone research   ISSN 0301-0163   CODEN HRMRA3
> Source / Source
> 2006, vol. 65, no6, pp. 276-288 [13 page(s) (article)]
> Langue / Language
> Anglais
>
> Editeur / Publisher
> Karger, Basel, SUISSE (1973) (Revue)
>
> Mots-clés d'auteur / Author Keywords
> Jeg3 ; Rye ; Green and yellow pea ; Estradiol ; Progesterone ; 5-
> Bromo-2'-deoxy-Uridine ;
> Localisation / Location
> INIST-CNRS, Cote INIST : 14766, 35400015668412.0030
>
> Copyright 2007 INIST-CNRS. All rights reserved
>
> Toute reproduction ou diffusion même partielle, par quelque procédé ou
> sur tout support que ce soit, ne pourra être faite sans l'accord
> préalable écrit de l'INIST-CNRS.
> No part of these records may be reproduced of distributed, in any form
> or by any means, without the prior written permission of INIST-CNRS.
>
> Nº notice refdoc (ud4) : 17830924
>
> -------------------------------
>
> "We recommend to use them in our diet as a good source of
> isoflavones."
>
> Published online 1 March 2007
> Published in Crop Sci 47:717-719 (2007)
> © 2007 Crop Science Society of America
> 677 S. Segoe Rd., Madison, WI 53711 USA This Article
>
> CROP PHYSIOLOGY & METABOLISM
> Production of Isoflavones in Seeds and Seedlings of Different Peanut
> Genotypes
> Ara Kirakosyana, Peter B. Kaufmana,*, James A. Dukeb, E. Mitchell
> Seymoura, Sara Warbera and Steven F. Bollinga
> a Univ. of Michigan Integrative Medicine Program (MIM), Univ. of
> Michigan, Ann Arbor, MI 48109
> b Herbal Vineyard, 8210 Murphy Rd., Fulton, MD 20759
>
> * Corresponding author (p...(a)umich.edu).
>
> The present study compares concentrations of medicinally important
> isoflavones in seeds versus seedlings of 20 selected peanut genotypes
> derived from widely different geographic sources and compares the
> total isoflavone concentrations in peanut (Arachis hypogaea L.) with
> those present in soybean [Glycine max (L.) Merr.] and kudzu [Pueraria
> montana (Lour.) Merr.]. Results of analyses of 20 different peanut
> genotypes showed that wide variation occurs in isoflavone
> concentrations both in peanut seeds and peanut seedlings; that peanut
> seedlings possess 0.8-fold to 27-fold higher concentrations of
> isoflavones than peanut seeds; that peanut seeds and seedlings possess
> little or no genistein; that peanut seeds contain one-half the
> concentrations of isoflavones as soybean seeds, and soybean seedlings
> contain four times higher concentrations of isoflavones than peanut
> seedlings; and that kudzu seeds and seedlings, in contrast, contain
> significantly higher concentrations of isoflavones than either peanut
> or soybean seeds and seedlings. In conclusion, because peanut
> seedlings and sprouts are better sources of isoflavones than peanut
> seeds, we recommend that the former be grown as a vegetable so as to
> use them in our diet as a good source of isoflavones. Furthermore, the
> wide variation in isoflavone concentrations in different peanut
> genotypes, as shown in this study, could be exploited by plant
> breeders as an easy and reasonable production strategy.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > On Apr 4, 4:41 pm, jay <jaym1...(a)hotmail.com> wrote: A Soy Diet
> > Accelerates Renal Damage in Autoimmune MRL/Mp-lpr/lpr Mice. <<
>
> > What kind of mice were those .. again .. ?
>
> > "Isoflavone supplementation for systemic lupus erythematosus patients
> > should be carefully reevaluated"
>
> > Oh .. they are trying to get the present supplementation IN ..
> > lupus .. repealed .. ?
>
> > They concluded they have to reevaluate the supplementation of ..
> > isofavones .. ?
>
> > That's too .. bad.
>
> > They have some work ahead of them ..
>
> > I bet you wish them the .. best .. don't ya .. jay ..
>
> > Heh .. heh ..
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
> > > > ... Also meriting consideration is the allergenic response
> > > > that may sometimes occur in humans, as well as calves
> > > > and piglets, on dietary exposure to soybeans.
>
> > > A Soy Diet Accelerates Renal Damage in Autoimmune MRL/Mp-lpr/lpr Mice.
>
> > > Isoflavones, which are phytoestrogens present in large quantities in
> > > soy and soy-derived products, have estrogenic activity, inhibit
> > > protein tyrosine kinase, and exert other effects in the human body.
> > > Thus, the recent spread of soy consumption in Western populations
> > > emphasizes the need to more fully understand the potential effects in
> > > the body, especially in abnormal immune conditions. In the present
> > > study, the influence of a soy diet on lupus disease in MRL/Mp-lpr/lpr
> > > (MRL/lpr) mice was investigated. Weanling female MRL/lpr mice (4
> > > weeks) were fed a soy diet (20% soybean protein and 5% soybean oil).
> > > The soy diet exacerbated renal damage; findings in this mouse strain
> > > included accelerated proteinuria, elevated serum creatinine
> > > concentrations, and reduced creatinine clearance. No effects were
> > > detected, however, in C3H/HeN mice, which have the same H-2(k) genetic
> > > background as MRL/lpr mice do. A tendency toward an increase in thymus
> > > weight and proliferation of T cells in spleen and B cells in lymph
> > > nodes were found at the age of 16 weeks. These findings indicate that
> > > a soy diet, in comparison with a casein diet, significantly
> > > exacerbates the clinical course of this autoimmune disease. Further
> > > research on the mechanism of this effect of soy-rich diets is needed,
> > > and isoflavone supplementation for systemic lupus erythematosus
> > > patients should be carefully reevaluated.
>
> > > PMID: 16039550- Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

From: Marshall Price on 6 Apr 2008 18:06
spam.stock(a)yahoo.fr wrote:
>
> ironjustice wrote:
>> http://www.medscape.com/viewarticle/572440
>>
>> April 3, 2008 -- Intake of soy protein had beneficial effects on
>> cardiovascular risk factors and kidney-related biomarkers in patients
>> with type 2 diabetes and nephropathy, according to the results of a
>> longitudinal, randomized trial published in the April issue of
>> Diabetes Care.
>>
>> "Several short-term trials on the effect of soy consumption on
>> cardiovascular risks are available, but little evidence exists
>> regarding the impact of long-term soy protein consumption among type 2
>> diabetic patients with nephropathy," write Leila Azadbakht, PhD, from
>> the Isfahan University of Medical Sciences in Isfahan, Iran, and
>> colleagues. "To determine the effects of long-term soy consumption on
>> cardiovascular risks, we measured C-reactive protein (CRP) and kidney
>> function indexes among type 2 diabetic patients with nephropathy."
>>
>> Of 41 patients with type 2 diabetes and nephropathy who were enrolled
>> in this study, 18 were men and 23 were women. The soy protein group (n
>> = 20) was assigned to a diet containing 0.8 g protein/kg body weight
>> (35% animal proteins, 35% textured soy protein, and 30% vegetable
>> proteins), whereas the control group
>> (n = 21) was assigned to a similar diet containing 70% animal proteins
>> and 30% vegetable proteins. Duration of the study was 4 years.
>>
>> The soy protein group fared better than the control group regarding
>> effects on cardiovascular risk factors. Mean change in the soy protein
>> vs control groups for fasting plasma glucose levels was
>> -18 � 3 vs 11 � 2 mg/dL (P = .03); for total cholesterol levels,
>> -23 � 5 vs 10 � 3 mg/dL (P =.01); for low-density lipoprotein (LDL)
>> cholesterol levels, -20 � 5 vs 6 � 2 mg/dL (P = .01); and for serum
>> triglyceride levels, -24 � 6 vs -5 � 2 mg/dL (P = .01).
>>
>> Compared with the control group, the soy protein group also had
>> greater decreases in serum CRP levels (1.31 � 0.6 vs 0.33 � 0.1 mg/L;
>> P = .02) and significant reductions in proteinuria (-0.15 � 0.03 vs
>> 0.02 � 0.01 g/day;
>> P = .001) and urinary creatinine levels (-1.5 � 0.9 vs 0.6 � 0.3 mg/
>> dL; P = .01).
>>
>> Limitations of the study include evaluation of only CRP rather than
>> other inflammatory markers, evaluation of only a single dosage range
>> and formulation of soy protein, lack of data on the effects of soy
>> protein according to estrogen receptor genotype, and measurement of
>> urinary urea nitrogen and urinary creatinine as concentrations rather
>> than as 24-hour excretions.
>>
>> "Longitudinal soy protein consumption significantly affected
>> cardiovascular risk factors and kidney-related biomarkers among type 2
>> diabetic patients with nephropathy," the study authors write. "As
>> diabetic nephropathy is a progressive disease, we expected that the
>> conditions of these patients would have gotten worse after 4 years,
>> but because of medical and dietary control, their conditions improved
>> in some respects."
>>
>> The costs of publication of this article were defrayed in part by the
>> payment of page charges, mandating that it must therefore be hereby
>> marked "advertisement" solely to indicate this fact.
>>
>> Diabetes Care. 2008;31:648-654.
>>
>> Clinical Context
>> Diet is a cornerstone of the management of diabetes, and the authors
>> of the current study previously demonstrated that the inclusion of soy
>> and vegetable protein can improve laboratory variables in the short
>> term among patients with diabetes. They performed a crossover clinical
>> trial among 14 patients with diabetes and nephropathy, which was
>> published in the October 2003 issue of the European Journal of
>> Clinical Nutrition. In this study, the use of a diet in which 35% of
>> the protein was derived from soy and another 30% from vegetable
>> sources improved levels of total cholesterol, triglycerides, and LDL
>> cholesterol after 7 weeks. The soy and vegetable protein diet also
>> reduced proteinuria but did not affect levels of high-density
>> lipoprotein (HDL) cholesterol.
>>
>> The current study observes a larger patient cohort for a longer period
>> to determine the significance of a soy protein diet among patients
>> with type 2 diabetes and nephropathy.
>>
>> Study Highlights
>> Participants in the current study had type 2 diabetes and proteinuria,
>> with a total urinary protein excretion between 300 and 1000 mg/day.
>> Participants' serum creatinine level was between 1 and 2.5 mg/dL, and
>> the serum urea nitrogen level was between 20 and 40 mg/dL. Subjects'
>> systolic and diastolic blood pressure was greater than 140 and 90 mm
>> Hg, respectively.
>> Subjects were randomized to a control diet consisting of 0.8 g protein/
>> kg body weight, with 70% animal protein and 30% vegetable protein; or
>> a soy protein group consisting of 0.8 g protein/kg body weight, with
>> 35% animal protein, 35% soy protein, and 30% vegetable proteins.
>> Participants received visits with a dietician to encourage adherence
>> to their randomized diet.
>> The outcomes of the study were renal function, degree of proteinuria,
>> serum lipid levels, and CRP levels. These outcomes were assessed every
>> 6 months for 4 years.
>> 41 participants provided data for analysis. 43% of subjects were men,
>> and the mean age of subjects was 62.1 years. The mean duration of
>> diabetes was 10 years, and the mean glycated hemoglobin level was
>> 6.2%.
>> There was no difference in total mean energy intake or activity levels
>> between groups during the trial.
>> Mean body weight was similar between diet groups at 4 years.
>> Mean fasting plasma glucose levels decreased by 18 mg/dL in the soy
>> protein diet group but increased by 11 mg/dL in the control group,
>> which is a significant difference.
>> Total cholesterol levels decreased by 23 mg/dL in the soy protein diet
>> group and increased by 5 mg/dL in the control group, which was also
>> statistically significant. LDL cholesterol and triglyceride levels
>> also were reduced more significantly in the soy protein vs the control
>> diet groups. HDL cholesterol levels were similar in both groups.
>> CRP levels decreased by 1.31 in the soy protein diet group and 0.33 in
>> the control group, which is a significant difference.
>> Proteinuria decreased slightly in the soy protein diet group and
>> increased slightly in the control group, and this difference was also
>> statistically significant.
>> Urinary urea nitrogen and urinary creatinine levels were improved in
>> the soy protein vs control diet groups, but serum creatinine and serum
>> urea nitrogen levels and the glomerular filtration rate were similar
>> at 4 years between groups.
>> The favorable effects of the soy protein diet on proteinuria were
>> independent of its effects on plasma glucose, but not lipid, levels.
>> Pearls for Practice
>> A small trial of a soy-based and vegetable-based protein diet among
>> patients with diabetes and nephropathy demonstrated that this diet
>> could reduce levels of total cholesterol, triglycerides, and LDL
>> cholesterol and decrease proteinuria in the short term.
>> The current study finds that a soy protein diet can reduce levels of
>> fasting plasma glucose, cholesterol, and CRP and decrease proteinuria
>> vs a control diet among patients with type 2 diabetes and nephropathy.
>> However, body weight was similar between the 2 groups.


I don't get it. What were the experimenters' conclusions?


--
Marshall Price of Miami
Known to Yahoo as d021317c
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