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From: Kofi on 12 Apr 2008 00:41
I wish to refine and extend my remarks on this interesting paper.

This paper indicates that chronic pain and fatigue may be due to a lack
of signalling through acid-sensing ion channel 3 (ASIC3) in muscles.
Testosterone is required to make that channel work, which may explain
why women are more likely to get chronic fatigue than men. It also may
say something about acidic vs. basic diets - *not* because these diets
can change your blood pH - they can't - but because these acid-sensing
channels also exist in the gut. They may pick up a signal from the pH
of our diet and *this* may then wind its way around our nervous systems,
affecting far-flung parts.

The low-affinity nerve growth factor receptor, p75NTR, is required for
ASIC3 to work [PMID 14522957] so this strongly suggest to me one method
whereby acetyl-l-carnitine (ALCAR) is responsible for alleviating
fatigue in patients with chronic fatigue. Testosterone is an ALCAR
transporter and ALCAR upregulates p75NTR which, thanks to this paper, we
now know is necessary for ASIC3 and relieving muscle fatigue. Since
some cancers grow and shrink via p75, taking ALCAR at a high dose (say
3g daily) will certainly alter your risk of getting some cancers (some
will go up, some will drop). ALCAR also improves butyrate uptake and
thus histone acetylation and Treg cell function which suppresses
autoimmunity. Oh, and p75 triggers catagen in hair follicles, causing
them to fall out and enter a rest phase.
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