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From: ironjustice on 13 Nov 2007 22:15
Scleroderma is a connective tissue disease thought to be related to
increased red blood cell production / erythrocytosis /
hemochromatosis / polycythemia.

Mt Sinai J Med. 2006 May;73(3):620-1.Links
Erythrocytosis in a scleroderma patient.
Mabo E, Edeki T, Westney GE, Reed JW, Guo X.
Department of Internal Medicine, Morehouse School of Medicine,
Atlanta, GA 30310, USA.

A 40-year-old black male with scleroderma lung disease presented with
blurry vision and headache. His presenting hemoglobin was 22.3 g/dL
and his serum erythropoietin level was surprisingly low. Although
nocturnal hypoxemia was evident, his daytime resting arterial oxygen
saturation was normal. The patient's symptoms of hyperviscosity
improved after phlebotomy, as his hemoglobin gradually decresed to
18.3 g/dL. Repeat serum erythropoietin levels were in normal and high
ranges. Patients with chronic interstitial lung disease and
erythrocytosis could have normoxemia at rest and a normal or low serum
erythropoietin level at the peak of erythrocytosis. A repeat sampling
of serum erythropoietin and monitoring of oxygen saturation during
sleep and exertion may help in diagnosis. Physicians should prescribe
continuous oxygen therapy for patients with chronic interstitial lung
disease and erythrocytosis, even if diurnal resting hypoxemia is
absent.

PMID: 16758101 [PubMed - indexed for MEDLINE]


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