From: Kofi on
A link between Celiac and schizophrenia has been postulated before.
Some schizophrenics have even been cured with a gluten-free diet. Now
we have evidence that Celiac and some forms of schizophrenia may both be
driven by antibodies to different antigen targets in wheat.

Given that wheat, rice, red meat and cow's milk contain opioids, it may
be the case that the immune crossreaction in this form of schizophrenia
winds up targeting certain opioid sites. Opioid ligands play an
important role in regulating pain and stress, so it's conceivable this
could result in neurological changes - even permanent damage if the
brain could not react properly to redox stress because of interfering
antibodies (I'm thinking here of the interneurons affected in

Schizophr Res. 2009 Sep 10;

Novel immune response to gluten in individuals with schizophrenia.
Samaroo D, Dickerson F, Kasarda DD, Green PH, Briani C, Yolken RH,
Alaedini A.
Department of Neurology and Neuroscience, Weill Medical College of
Cornell University, New York, NY, United States.

A link between celiac disease and schizophrenia has been postulated for
several years, based primarily on reports of elevated levels of antibody
to gliadin in patients. We sought to examine the proposed connection
between schizophrenia and celiac disease by characterizing the molecular
specificity and mechanism of the anti-gliadin immune response in a
subset of individuals with schizophrenia. Blood samples from individuals
with schizophrenia and elevated anti-gliadin antibody titer were
examined for celiac disease-associated biomarkers, including antibodies
to transglutaminase 2 (TG2) enzyme and deamidated gliadin peptides, as
well as the HLA-DQ2 and -DQ8 MHC genes. The anti-gliadin antibody
response was further characterized through examination of reactivity
towards chromatographically separated gluten proteins. Target proteins
of interest were identified by peptide mass mapping. In contrast to
celiac disease patients, an association between the anti-gliadin immune
response and anti-TG2 antibody or HLA-DQ2 and -DQ8 markers was not found
in individuals with schizophrenia. In addition, the majority of
individuals with schizophrenia and anti-gliadin antibody did not exhibit
antibody reactivity to deamidated gliadin peptides. Further
characterization of the antibody specificity revealed preferential
reactivity towards different gluten proteins in the schizophrenia and
celiac disease groups. These findings indicate that the anti-gliadin
immune response in schizophrenia has a different antigenic specificity
from that in celiac disease and is independent of the action of
transglutaminase enzyme and HLA-DQ2/DQ8. Meanwhile, the presence of
elevated levels of antibodies to specific gluten proteins points to
shared immunologic abnormalities in a subset of schizophrenia patients.
Further characterization and understanding of the immune response to
gluten in schizophrenia may provide novel insights into the
etiopathogenesis of specific disease phenotypes.

PMID: 19748229
From: Tim on
Some societies don't seem to have schizophrenia.