STUDY: Clinical and morphological conditions in capsular contracture formed around silicone breast implants.
in [Immunology]
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From: Ilena Rose on 14 Jun 2008 11:16 From Health Lover, Ilena Rosenthal www.BreastImplantAwareness.org/ http://breastimplantawareness.blogspot.com http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17572576&itool=pubmed_DocSum 1: Plast Reconstr Surg. 2007 Jul;120(1):275-84. Clinical and morphological conditions in capsular contracture formed around silicone breast implants. Prantl L, Schreml S, Fichtner-Feigl S, P�ppl N, Eisenmann-Klein M, Schwarze H, F�chtmeier B. Department of Plastic Surgery, University Hospital Regensburg, Regensburg, Germany. lukas.prantl @ klinik.uni-regensburg.de BACKGROUND: A study was performed to investigate histological changes in capsules formed around silicone breast implants and their correlation with the clinical classification of capsular contracture defined by the Baker score. For histological classification, the authors used the classification introduced by Wilflingseder, which identifies four grades of contracture. METHODS: The study included 24 female patients (average age, 40 +/- 12 years) with capsular contracture after bilateral cosmetic breast augmentation with smooth silicone gel implants (Mentor, Santa Barbara, Calif.). The Baker score was determined preoperatively for each patient. Samples of capsular tissue were obtained from all patients for histologic and immunohistochemical analyses. Capsular thickness, age of the collagen fibers, presence of synovia-like metaplasia on the inner surface of the capsule, number of histiocytes, giant cells, and other inflammatory cells, amount of silicone, foreign body granulomas, and capsule calcification were evaluated. RESULTS: There was a positive correlation between capsular thickness (p < 0.05) and Baker score. Silicone-containing deposits were found in all four histological capsule types. A trend toward greater capsular thickness was documented in patients with severe inflammatory reaction. These patients also had more clinical symptoms. Greater capsular thickness was associated with a higher number of silicone particles and silicone-loaded macrophages in the peri-implant capsule. CONCLUSIONS: The authors demonstrated a positive correlation (p < 0.05) between the clinical classification (Baker score I to IV) and the histological classification introduced by Wilflingseder (Wilflingseder score I to IV). An exact histological classification is needed to describe precisely the morphological changes in capsular contracture. PMID: 17572576 [PubMed - in process] (No Related Articles yet for this citation.) Display Show |