Ribavirin promotes liver fibrosis
in [Hepatitis]
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From: ironjustice on 2 Apr 2007 14:28 Ribavirin causes .. hemolysis / glorified bloodletting .. but it seems .. MUCH .. more .. **deadly**. <<snip>> hemolysis is responsible for iron overload, liver iron deposition, and an acceleration in the progression of liver fibrosis <<snip>> Ribavirin promotes liver fibrosis in HCV-positive kidney recipients Hepatitis Weekly via NewsEdge Corporation : 2005 MAY 23 - (NewsRx.com) -- Ribavirin promotes liver fibrosis in HCV- positive kidney recipients. According to published research from France, "in untreated hepatitis virus (HCV)-positive renal transplant patients, the rate of liver fibrosis progression is low. In contrast, in those treated by ribavirin monotherapy, liver fibrosis score increased significantly after only 1 year of ribavirin monotherapy. The aim of this study was to identify the factors that might contribute to accelerate liver fibrosis progression in this population." "Eleven patients were included in the study. Intrahepatic transforming growth factor (TGF)-beta, interferon (IFN)-gamma, and interleukin (IL)-10 mRNA quantification determined by real-time reverse transcription-polymerase chain reaction (RT-PCR) were similar before and after ribavirin therapy," according to N. Kamar and colleagues, CHU Rangueil, Department of Nephrology, Dialysis and Transplantation. "The number of amino acid substitutions observed in the hypervariable region (HVR)-1 of the HCV genome between baseline and 1 year after ribavirin monotherapy was low, i.e, 3 (1-11) amino acid substitutions, suggesting the absence of a high selection pressure induced by ribavirin. In contrast, due to ribavirin-induced hemolysis, there was a significant increase in serum ferritin levels (p=0.02) and in intrahepatic iron deposition (p=0.04). Transferrin level and total iron-binding capacity decreased significantly during ribavirin monotherapy (p=0.004). "The increased liver fibrosis observed in renal transplant patients receiving ribavirin monotherapy could be related to ribavirin-induced anemia. Severe chronic hemolysis is responsible for iron overload, liver iron deposition, and an acceleration in the progression of liver fibrosis," study authors suggested. Kamar and colleagues published their findings in the Journal of Medical Virology (Factors accelerating liver fibrosis progression in renal transplant patients receiving ribavirin monotherapy for chronic hepatitis C. J Med Virol, 2005;76(1):61-68). Additional information can be obtained by contacting N. Kamar, CHU Rangueil, Department Nephrology, Dialysis & Transplantation, 1, Avenue Jean Poulhes, TSA 50032, F-50032 Toulouse, France. The publisher of the Journal of Medical Virology can be contacted at: Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA. Keywords: Toulouse, France, Biotechnology, Hepatitis C Virus, Hepatology, Liver Fibrosis, Renal Transplantation, Transplantation Medicine, Virology. This article was prepared by Hepatitis Weekly editors from staff and other reports. Copyright 2005, Hepatitis Weekly via NewsRx.com. <<Hepatitis Weekly -- 05/24/05>> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: *GED* on 3 Apr 2007 07:59 On Apr 2, 7:28 pm, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: > Ribavirin causes .. hemolysis / glorified bloodletting .. but it > seems .. MUCH .. more .. **deadly**. > The Ribavirin is a nasty drug to have to take,I was taking it for a year over four years ago and some of the side effects are still with me !!!.Same as the Interferon I suppose we are stuck with them until something better comes along.All I would say to anyone taking it now is just stick with it,I know it cleaned me up and chances are it will do the same for you.
From: Jason on 3 Apr 2007 14:44 In article <1175601583.087706.186270(a)y80g2000hsf.googlegroups.com>, "*GED*" <flanneryged(a)yahoo.co.uk> wrote: > On Apr 2, 7:28 pm, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: > > Ribavirin causes .. hemolysis / glorified bloodletting .. but it > > seems .. MUCH .. more .. **deadly**. > > > The Ribavirin is a nasty drug to have to take,I was taking it for a > year over four years ago and some of the side effects are > still with me !!!.Same as the Interferon I suppose we are stuck with > them until something better comes along.All I would say to anyone > taking it now is just stick with it,I know it cleaned me up and > chances are it will do the same for you. ~~~~~~~~~~~~~~~~~~~~ Statins are another drug that can cause side effects that can effect patients for the rest of their lives. For example, thousands of people now have a terrible disorder called Rhabdomyolysis and serious memory problems as a direct result of statins. I was shocked when I read the book mentioned below about the dangers of statins. However, millions of people do not suffer from side effects as a result of taking statins. WHAT YOU MUST KNOW ABOUT STATIN DRUGS AND THEIR NATURAL ALTERNATIVES by Jay S. Cohen, M.D. Also visit this site: www.spacedoc.net
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