From: poohbearwoods on

Rheumatoid Arthritis - Treatment - Chang Shan - Anti-Inflammatory

Medical researchers have identified Halofuginone as a treatment for
Rheumatoid Arthritis. Halofuginone is a drug derived from the
ancient herb Chang Shan (Latin botanical name: Dichroa Root).

Chang Shan, herb has been used in Chinese medicine for more than 2,000
years to reduce fever and fight malaria. Chang Shan is considered one
of the 50 "fundamental herbs" of traditional Chinese medicine.

Researchers have now discovered that in the body, one common precursor
T cell can give rise to both tissue-protective T regulatory, or Treg,
cells and the inflammatory T cell type known as T helper 17.

These inflammatory Th17 cells play a prominent role in many autoimmune-
related disorders, such as Rheumatoid Arthritis, Multiple Sclerosis,
Scleroderma, Inflammatory Bowel Disease and Psoriasis.

Researchers have discovered a small molecule called Halofuginone
prevented inflammatory Th17 cells from emerging without interfering
with tissue-protective Treg cells.

The researchers believe that halofuginone acts by activating a
biochemical pathway known as the amino acid starvation response, or
AAR, which typically protects cells when amino acids, the essential
building blocks of proteins, are in short supply.

In amino acid deprivation, cells try to conserve amino acids by
preventing specific types of responses that are energetically
expensive. A primary response of these cells to halofuginone is
shutting down the inflammatory response cycle.

Emerging science indicates that Rheumatoid Arthritis Sufferers may
reap the greatest benefit from this anti-inflammatory compound. With
this new discovery it is now possible to inhibit this destructive and
repetitive chronic autoimmune cycle from reoccurring. In essence,
allowing the body to repair itself..!