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From: Kofi on 11 Sep 2008 20:59
In article
<7360e33b-d1cd-4c66-bd21-9d52904297dc(a)m36g2000hse.googlegroups.com>,
jay <jaym1212(a)hotmail.com> wrote:

> > ... any direct study of resveratrol's effects on Tregs ...
>
> It is my suspicion that Persistent Organic Pollutants (ie TCDD, a
> potent dioxin), their activation of Aryl Hydrocarbon-Mediated
> Detoxification Pathways, and interaction with endo/exogenous estrogens
> in genetically-predisposed persons are involved in Crohn's Disease.
> Below are two studies that indirectly indicate that resveratrol may
> rebalance TRegs when affected by TCDD.

Well, you might want to avoid low-dose aspirin then. It elevates HDL
via the aryl hydrocarbon receptor.
From: jay on 12 Sep 2008 15:50
> > Below are two studies that indirectly indicate that resveratrol may
> > rebalance TRegs when affected by TCDD.
>
> Well, you might want to avoid low-dose aspirin then.  
> It elevates HDL via the aryl hydrocarbon receptor.

Most fruits and veggies bind Ah receptors. Citrus and cruciferous
veggies are among the strongest. Salicylic acid, the active part of
aspirin, is ubiquitous in plants. But I have yet to see any pubmed
abstracts that indicate aspirin binds with Ah Receptors. Below is the
closest:

The drug salicylamide is an antagonist of the aryl hydrocarbon
receptor that inhibits signal transduction induced by 2,3,7,8-
tetrachlorodibenzo-p-dioxin.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread
environmental contaminant, that has been linked with a variety of
deleterious effects on human health, including increased cancer rates
and reproductive anomalies. The detrimental effects of TCDD are
mediated via the aryl hydrocarbon receptor (AhR), a transcription
factor that regulates the expression of the carcinogen-activating
enzymes cytochromes P-450 (CYP) 1A1, 1A2, and 1B1. In the present
study, we examined the ability of synthetic derivatives of salicylic
acid to affect TCDD-stimulated AhR-mediated signal transduction in
human hepatoma HepG2 cells. Salicylamide (SAL), an analgesic drug,
caused a potent and long-lasting inhibition of TCDD-induced CYP enzyme
activity. Acetylsalicylic acid (aspirin) and the naturally occurring
phytochemical salicylic acid had no effect on CYP activity. SAL
inhibited the increase in CYP1A1, -1A2, and -1B1 mRNA levels that
occurs on exposure to TCDD. TCDD-induced transcription of these genes
was also inhibited by SAL, but not by aspirin or salicylic acid, as
demonstrated by luciferase reporter assays. The transcription of the
CYP1 family of genes is regulated by the interaction of TCDD-activated
AhR with the xenobiotic-responsive element present in the promoter
regions of these genes. As shown by electrophoretic mobility shift
assay, SAL completely blocked the binding of TCDD-activated AhR to the
xenobiotic responsive element. Also, SAL substantially blocked the
binding of TCDD to the cytosolic AhR. These results demonstrate that
SAL, a commonly used analgesic, is a potent inhibitor of AhR-mediated
signal transduction, and may be an effective agent in the prevention
of TCDD-associated disease. PMID: 14729655
From: jay on 13 Sep 2008 17:34
> ... Salicylic acid, the active part of aspirin, is ubiquitous in plants.

Salicylic acid content of spices and its implications.
This work was done to determine the salicylate content of a variety of
commonly used spices and to assess whether this potential dietary
source of salicylate was bioavailable. Spices, Indian cooked dishes,
and blood and urine samples taken after ingestion of a test meal were
investigated for their salicylate content using high-performance
liquid chromatography with electrochemical detection. The serum
salicylic acid concentrations in samples from villagers in southern
India were also measured and have been compared with typical European
values. Salicylic acid was determined in all spices (up to 1.5 wt %)
and cooked dishes. The salicylate content of blood and urine was shown
to increase following consumption of the meal, indicating that this
dietary source of salicylic acid was bioavailable. Salicylic acid
levels in the serum from rural Indians were significantly (median
almost 3-fold) higher than values previously measured in Western
vegetarians. Chemoprotective aspirin is rapidly hydrolyzed to
salicylic acid, and this phytochemical may contribute to the low
cancer incidence in rural India. PMID: 16608205
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