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From: futurespeak on 26 Jul 2008 11:11
Resveratrol can help you to lead a long and healthy life so says Dr.
Oz.
Red wine alone does not supply enough resveratrol to achieve the
full range of benefits. You need to take high potency resveratrol
supplements to achieve the results documented in scientific studies.
Resveratrol Supplements can also help you control your weight
naturally
by increasing energy, reducing cravings, and limiting your appetite.
According to Wikipedia, Consumer Lab, an independent dietary
supplement and over the counter products evaluation organization,
published a report on 13 November 2007 on the popular resveratrol
supplements. The organization reported that there exists a wide range
in quality, dose, and price among the 13 resveratrol products
evaluated. The actual amount of resveratrol contained in the
different brands range from 2.2mg for Revatrol, which claimed to have
400mg of "Red Wine Grape Complex", to 500mg for Biotivia.com
Transmax,
which is consistent with the amount claimed on the product's label.
Prices per 100mg of resveratrol ranged from less than $.30 for
products made by Biotivia.com, jarrow, and country life, to a high of
$45.27 for the Revatrol brand.

From: Kofi on 5 Aug 2008 01:07
Resveratrol acts on angiotensin II. Substances in this class often
attenuate TGF-beta - which is a bad idea for autoimmune patients because
this lowers regulatory T-cell activity. I'm unaware of any direct study
of resveratrol's effects on Tregs. However, foods rich in resveratrol
often contain ACE inhibitors. You need ACE to degrade Substance P, a
pain neurotransmitter that is often elevated in people with magnesium
deficiency. Magnesium deficiency is common in autoimmune digestive
disorders and it can cause chronic pain conditions. If you have this
set of problems, taking products like grape seed extract to get the
resveratrol can result in greater pain.
From: jay on 9 Aug 2008 21:42
> ... any direct study of resveratrol's effects on Tregs ...

It is my suspicion that Persistent Organic Pollutants (ie TCDD, a
potent dioxin), their activation of Aryl Hydrocarbon-Mediated
Detoxification Pathways, and interaction with endo/exogenous estrogens
in genetically-predisposed persons are involved in Crohn's Disease.
Below are two studies that indirectly indicate that resveratrol may
rebalance TRegs when affected by TCDD.

http://www.nature.com/nature/journal/v453/n7191/edsumm/e080501-10.html

Toxins and autoimmunity
The aryl hydrocarbon receptor (AHR) is a transcription factor best
known for mediating the toxicity of aromatic hydrocarbons such as
dioxin: its activation leads to the production of detoxification
enzymes. AHR has been intensely studied in relation to toxicology and
cancer research, but no mechanistic connection to the immune system
was known. Now two groups report a role for AHR in maintaining the
balance between two T-lymphocyte populations — the Treg and TH17 cells
— that are part of the immune regulation system dealing with tolerance
of self-antigens and pathogen clearance. Both groups also show that
AHR affects the severity of experimental autoimmune encephalitis, a
mouse model of multiple sclerosis. This work raises the possibility
that stimulation of AHR by environmental factors could be involved in
the development of autoimmune disease, and point to AHR as a possible
drug target for immunomodulation.


Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and
catechol estrogen-mediated oxidative DNA damage in cultured human
mammary epithelial cells.
Resveratrol (3,5,4'-trihydroxystilbene), a naturally occurring
phytoalexin present in grapes and other foods, has been reported to
possess chemopreventive effects as revealed by its striking inhibition
of diverse cellular events associated with tumor initiation, promotion
and progression. In our present study, 2,3,7,8-tetrachlorodibenzo-p-
dioxin (TCDD), when treated with the cultured human mammary epithelial
(MCF-10A) cells, induced the expression of cytochrome P450 1A1
(CYP1A1) and 1B1 (CYP1B1) that are responsible for the oxidation of
17ß-estradiol to produce catechol estrogens. Resveratrol strongly
inhibited the TCDD-induced aryl hydrocarbon receptor (AhR) DNA binding
activity, the expression of CYP1A1 and CYP1B1 and their catalytic
activities in MCF-10A cells. It also reduced the formation of 2-
hydroxyestradiol and 4-hydroxyestradiol from 17ß-estradiol by
recombinant human CYP1A1 and CYP1B1, respectively. Furthermore,
resveratrol significantly attenuated the intracellular reactive oxygen
species (ROS) formation and oxidative DNA damage as well as the
cytotoxicity induced by the catechol estrogens. Our data suggest that
CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a
key role in TCDD-induced oxidative damage, and resveratrol can act as
a potential chemopreventive against dioxin-induced human mammary
carcinogenesis by blocking the metabolic formation of the catechol
estrogens and scavenging the ROS generated during their redox cycling.
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