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From: Matti Narkia on 14 Aug 2008 08:40
Taka wrote:
> On Aug 13, 4:08 pm, soowhatdouth...(a)hotmail.com wrote:
>> Chem Res Toxicol. 2008 Feb;21(2):282-7. Epub 2008 Jan 5.
>> Effect of methyl substitution on the antioxidative property and
>> genotoxicity of resveratrol.
>> Fukuhara K, Nakanishi I, Matsuoka A, Matsumura T, Honda S, Hayashi M,
>> Ozawa T, Miyata N, Saito S, Ikota N, Okuda H.
>> Division of Organic Chemistry, National Institute of Health Sciences,
>> Setagaya-ku, Tokyo 158-8501, Japan. fukuh...(a)nihs.go.jp
>>
>> Resveratrol ( trans-3,4',5-trihydroxystilbene) is a natural
>> phytoalexin with various biological activities including inhibition of
>> lipid peroxidation and free radical scavenging properties. In addition
>> to its beneficial effects, resveratrol also has significant
>> genotoxicity that leads to a high frequency of chromosome aberration
>> together with micronucleus and sister chromatid exchanges. To enhance
>> the radical scavenging activities and to reduce the genotoxicity of
>> resveratrol, we designed 4'-methyl resveratrol analogues where a
>> methyl group was introduced at the ortho position relative to the 4'-
>> hydroxy group, which is responsible for both antioxidative activities
>> and genotoxicity of resveratrol. These synthesized methyl analogues of
>> resveratrol showed increased antioxidative activities against
>> galvinoxyl radical as an oxyl radical species. Furthermore, the methyl
>> analogues also surprisingly showed reduced in vitro genotoxicities,
>> suggesting that methyl substitution may improve resveratrol efficacy.
>>
>> PMID: 18177016 [PubMed - indexed for MEDLINE]
>
> All these "antioxidants" as well as Omega-3 fatty acids exert their
> health "benefits" at least in part by damaging DNA leading to
> apoptosis.

References, please.


--
Matti Narkia

http://ma.gnolia.com/groups/Nutrition
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