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From: ironjustice on 14 Jul 2008 19:06
On Jul 14, 3:56 pm, Michael B <baugh...(a)bellsouth.net> wrote: snip <<

What part of stay off **my** threads don't ya understand .. ?
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Free radicals and antioxidants in primary fibromyalgia: an oxidative
stress disorder?
Journal Rheumatology International


Original Article
Free radicals and antioxidants in primary fibromyalgia: an oxidative
stress disorder?
Selda Bagis1, 4 , Lulufer Tamer2, Gunsah Sahin1, Ramazan Bilgin3,
Hayal Guler1, Bahadir Ercan2 and Canan Erdogan1


(1) Physical Medicine and Rehabilitation Department, Mersin
University Medical School, Mersin, Turkey
(2) Biochemistry Department, Mersin University Medical School,
Mersin, Turkey
(3) Biochemistry Department, Art and Science Faculty, Cukurova
University, Adana, Turkey
(4) Guzelyali mah. 15.sok. Bilgin apt., Kat:6 No:11, 01120 Adana,
Turkey


Received: 24 March 2003 Accepted: 31 October 2003 Published online:
20 December 2003


Abstract The role of free radicals in fibromyalgia is controversial.
In this study, 85 female patients with primary fibromyalgia and 80
age-, height-, and weight-matched healthy women were evaluated for
oxidant/antioxidant balance. Malondialdehyde is a toxic metabolite of
lipid peroxidation used as a marker of free radical damage.
Superoxide
dismutase is an intracellular antioxidant enzyme and shows
antioxidant
capacity. Pain was assessed by visual analog scale. Tender points
were
assessed by palpation. Age, smoking, body mass index (BMI), and
duration of disease were also recorded. Malondialdehyde levels were
significantly higher and superoxide dismutase levels significantly
lower in fibromyalgic patients than controls. Age, BMI, smoking, and
duration of disease did not affect these parameters. We found no
correlation between pain and number of tender points. In conclusion,
oxidant/antioxidant balances were changed in fibromyalgia. Increased
free radical levels may be responsible for the development of
fibromyalgia. These findings may support the hypothesis of
fibromyalgia as an oxidative disorder.
Keywords Antioxidant - Fibromyalgia - Oxidant
Publisher Springer Berlin / Heidelberg
ISSN 0172-8172 (Print) 1437-160X (Online)
Issue Volume 25, Number 3 / April, 2005
Category Original Article
DOI 10.1007/s00296-003-0427-8


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