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From: trigonometry1972 on 2 Jan 2010 14:48
http://www.proteinpower.com/drmike/uncategorized/heartburn-cured/

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266058/

Check out the conclusion:

PPIs may modulate not only gastric H+/K+-ATPase
activity, but also v-type H+-ATPase activity,
which is widely distributed in a variety of
cells in the human body. Among these, the
acid-producing systems in osteoclasts and
leukocytes are well developed for maintaining
bone turnover and exhibit bactericidal roles
and promote tissue-destructive inflammation.
Therefore, there is still much potential
for research on the pharmacological and
clinical aspects of PPI treatment.
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Ann Pharmacother. 2007 Jul;41(7):1315-7.
Epub 2007 Jul 3.

Rabeprazole and psychiatric symptoms.

Polimeni G, Cutroneo P, Gallo A, Gallo S,
Spina E, Caputi AP.

Istituto di Ricovero e Cura a Carattere
Scientifico Centro Neurolesi
Bonino-Pulejo, Messina, Italy.
gpolimeni(a)unime.it

OBJECTIVE:
To report the case of a patient who developed marked
anxiety associated with episodes of panic attacks after
starting rabeprazole therapy.

CASE SUMMARY:
An otherwise healthy 55-year-old woman was prescribed
rabeprazole 20 mg/day administered in the morning for
persistent symptoms of dyspepsia. Ten days later,
she presented with a 7 day history of marked anxiety
associated with panic attacks, night terror (pavor
nocturnus), episodic mental confusion, and attention
deficit. Within 2 days of discontinuing rabeprazole,
the patient recovered completely from the neuropsychiatric
manifestations. Subsequent esomeprazole therapy did not cause
psychiatric symptoms.

DISCUSSION:
Rabeprazole-induced hypergastrinemia may have
played a role in this neuropsychiatric adverse
reaction. Several lines of evidence have indicated
that gastrin-releasing peptide, whose release is
mediated by proton pump inhibitor (PPI)-induced
secretion of gastrin, is involved in regulating
aspects of behavior that might be altered in disorders
such as anxiety, depression, and dementia. The fact
that rabeprazole has the highest capacity of inducing
gastrin increase compared with other PPIs might
explain why our patient's panic symptoms disappeared
after switching to esomeprazole. Based on the Naranjo
probability scale, rabeprazole was the probable
cause of the adverse reaction.

CONCLUSIONS:
Specific studies are needed to investigate
the potential role of PPI-induced
hypergastrinemia in neuropsychiatric adverse
reactions.

PMID: 17609230 [PubMed - indexed for MEDLINE]
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