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From: Larry on 6 Aug 2008 11:16
On Aug 5, 9:45 am, Susan <neverm...(a)nomail.com> wrote:
> x-no-archive: yes
>
> louise wrote:
> > For clarification - I'm on the BP spectrum, non-psychotic, diagnosed BPII
>
> Louise, I wasn't speculating as to your diagnosis so much as wanting to
> provide information on the mechanism.  Bipolar disorder is a very
> frequent manifestation of hypercortisolemia, which should always be
> evaluated with a multitude of tests before a psych diagnosis is given,
> especially since both the cortisol and the psych meds can cause diabetes
> or worsen it and make it treatment resistant.
>
> Mifepristone works for BPD.
>
> Susan

Susan: Regarding possible adverse effects possibly related to high
dose metformin, Did you say you were aware of either the FDA and or
the drug company looking into adrenal suppression and or electrolyte
imbalances as a result? I also would like to look into this potential
problem but I thought you can tell me how far you have gone with it
which could save me a step or two in researching it in terms of what
is being done about it if in fact metformin is the culprit. Thanks.

Larry/T2
Lantus/reduced dose metformin/low dose Amaryl.
2nd degree heart block/ resolving ?
From: Susan on 6 Aug 2008 11:47
x-no0-archive: yes

Larry wrote:

> Susan: Regarding possible adverse effects possibly related to high
> dose metformin, Did you say you were aware of either the FDA and or
> the drug company looking into adrenal suppression and or electrolyte
> imbalances as a result? I also would like to look into this potential
> problem but I thought you can tell me how far you have gone with it
> which could save me a step or two in researching it in terms of what
> is being done about it if in fact metformin is the culprit. Thanks.


No, I didn't say that. You may be recalling that I mentioned the NIH is
undertaking to study how badly statins suppress adrenal function, since
all of our adrenal steroids are manufactured from LDL cholesterol, which
goes up when our body needs more of those hormones.

The FDA and drug companies are completely useless and negligent in this
regard. For example, they list symptoms of adrenal suppression and
failure for a million drugs in the PDR, but fail to mention that the
drugs are causing adrenal failure or suppression outright. This came to
light for me when I told an inf. diseases doc I couldn't take anti
fungals because they shut down adrenal function, particularly
ketoconazole. He'd been rx'ing this drug for decades; it's used to
treat Cushing's syndrome because it literally shuts down cortisol
production in the adrenals. There are case reports of adrenal failure
with other anti fungals, too. When we looked it up, nowhere was it
mentioned, just the non specific symptoms of adrenal failure; nausea,
headache, weakness, fatigue, etc...

Susan
From: Larry on 6 Aug 2008 17:10
On Aug 6, 8:47 am, Susan <neverm...(a)nomail.com> wrote:
> x-no0-archive: yes
>
> Larry wrote:
> > Susan: Regarding possible adverse effects possibly related to high
> > dose metformin, Did you say you were aware of either the FDA and or
> > the drug company looking into adrenal suppression and or electrolyte
> > imbalances as a result? I also would like to look into this potential
> > problem but I thought you can tell me how far you have gone with it
> > which could save me a step or two in researching it in terms of what
> > is being done about it if in fact metformin is the culprit. Thanks.
>
> No, I didn't say that. You may be recalling that I mentioned the NIH is
> undertaking to study how badly statins suppress adrenal function, since
> all of our adrenal steroids are manufactured from LDL cholesterol, which
> goes up when our body needs more of those hormones.
>
> The FDA and drug companies are completely useless and negligent in this
> regard.  For example, they list symptoms of adrenal suppression and
> failure for a million drugs in the PDR, but fail to mention that the
> drugs are causing adrenal failure or suppression outright.  This came to
> light for me when I told an inf. diseases doc I couldn't take anti
> fungals because they shut down adrenal function, particularly
> ketoconazole.  He'd been rx'ing this drug for decades; it's used to
> treat Cushing's syndrome because it literally shuts down cortisol
> production in the adrenals.  There are case reports of adrenal failure
> with other anti fungals, too.  When we looked it up, nowhere was it
> mentioned, just the non specific symptoms of adrenal failure; nausea,
> headache, weakness, fatigue, etc...
>
> Susan

Thank you Susan for your input. Yes I do remember your comments about
Statins. Right now I am wondering about electroyte imbalance which
metformin may cause. Particulary high potassium levels that it may
cause. As you may know electrolyte imbalance can cause heart block in
some patients of which I am coping with at the moment.

Larry
From: Susan on 6 Aug 2008 17:19
x-no-archive: yes

Larry wrote:

> Thank you Susan for your input. Yes I do remember your comments about
> Statins. Right now I am wondering about electroyte imbalance which
> metformin may cause. Particulary high potassium levels that it may
> cause. As you may know electrolyte imbalance can cause heart block in
> some patients of which I am coping with at the moment.

I think you need to have endocrine evaluation, and a standing renin and
aldosterone test (stand upright for 30 minutes prior to and during blood
draw) and other adrenal hormones.

In addition, if you're having problems with electrolyte balance, perhaps
you need to stop the metformin for a while and see if things improve.

Also, don't ever pump your fist or allow a tight tournequet to be used
for your serum testing; it raises the potassium results and renders them
completely inaccurate, as will shaking of the test tube, or sitting out
too long after draw.

Susan
From: Larry on 8 Aug 2008 00:34
On Aug 6, 2:19 pm, Susan <neverm...(a)nomail.com> wrote:
> x-no-archive: yes
>
> Larry wrote:
> > Thank you Susan for your input. Yes I do remember your comments about
> > Statins. Right now I am wondering about electroyte imbalance which
> > metformin may cause. Particulary high potassium levels that it may
> > cause. As you may know electrolyte imbalance can cause heart block in
> > some patients of which I am coping with at the moment.
>
> I think you need to have endocrine evaluation, and a standing renin and
> aldosterone test (stand upright for 30 minutes prior to and during blood
> draw) and other adrenal hormones.
>
> In addition, if you're having problems with electrolyte balance, perhaps
> you need to stop the metformin for a while and see if things improve.
>
> Also, don't ever pump your fist or allow a tight tournequet to be used
> for your serum testing; it raises the potassium results and renders them
> completely inaccurate, as will shaking of the test tube, or sitting out
> too long after draw.
>
> Susan

Hello Susan: Just saw my Endo. today here in San Diego. Pretty
competent young Doc I'd say. Anyway at my request GAD test was done
and results today show 14+... high and indicates LADA. I've been
diagnosed by at least 2 doc before as T2. I do believe the recent
findings particularly supported by todays GAD results. So now
metformin, actos are dc'd, amaryl tapered and more insulin ( bolus
PP ) added. Where is dear "old Al?"

Larry/T2 changed to T 1 1/2 after 6 years of IR drugs which did very
little. Misdiagnosis from the beginning.
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