Phlebotomy Prevents Thrombosis
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From: Robert Miles on 3 Jul 2008 10:28 "Harvey R. Stone" <hrstone(a)swbell.net> wrote in message news:Dr3bk.6309$LG4.1736(a)nlpi065.nbdc.sbc.com... > Reported for being off topic in Alt.support.arthritis,,,, cross posting > after being warned not to do it. > > Path: > nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy.com!nlpi057.nbdc.sbc.com!prodigy.net!border1.nntp.dca.giganews.com!nntp.giganews.com!postnews.google.com!l64g2000hse.googlegroups.com!not-for-mail > From: ironjustice <teamtanner(a)hotmail.com> [snip] Off topic in alt.support.diabetes too. Has ignored requests not to post off topic messages there. Note that groups-abuse(a)google.com is slow and not very effective at responding to reports of spam posted through Google groups, so I would expect them to be unlikely to act on reports of being off topic. However, it does help to report the same spammers over and over for different messages for at least 6 weeks, so perhaps groups-abuse(a)google.com just can't keep up with reading all their incoming mail.
From: ironjustice on 3 Jul 2008 10:31 On Jul 3, 7:28 am, "Robert Miles" <robertmi...(a)bellsouthNOSPAM.net> wrote:thrombosis << "Iron markedly accelerates thrombus formation" (Circulation. 2003;107:2601.) © 2003 American Heart Association, Inc. -------------------------------------------------------------------------------- Basic Science Reports Chronic Iron Administration Increases Vascular Oxidative Stress and Accelerates Arterial Thrombosis Sharlene M. Day, MD; Damon Duquaine, BS; Lakshmi V. Mundada, MS; Rekha G. Menon, MD; Bobby V. Khan, MD, PhD; Sanjay Rajagopalan, MD; William P. Fay, MD From the University of Michigan Medical School, Division of Cardiology, Ann Arbor (S.M.D., D.D., L.V.M., S.R., W.P.F.); and Emory University School of Medicine, Division of Cardiology, Atlanta, Ga (R.G.M., B.V.K.). Correspondence to Sharlene M. Day, MD, University of Michigan Medical Center, 7301 MSRB III, 1150 W Medical Center Dr, Ann Arbor, MI 48109-0644. E-mail s...(a)umich.edu Background Iron overload has been implicated in the pathogenesis of ischemic cardiovascular events. However, the effects of iron excess on vascular function and the thrombotic response to vascular injury are not well understood. Methods and Results We examined the effects of chronic iron dextran administration (15 mg over 6 weeks) on thrombosis, systemic and vascular oxidative stress, and endothelium-dependent vascular reactivity in mice. Thrombus generation after photochemical carotid artery injury was accelerated in iron-loaded mice (mean time to occlusive thrombosis, 20.4±8.5 minutes; n=10) compared with control mice (54.5±35.5 minutes, n=10, P=0.009). Iron loading had no effect on plasma clotting, vessel wall tissue factor activity, or ADP-induced platelet aggregation. Acute administration of DL-cysteine, a reactive oxygen species scavenger, completely abrogated the effects of iron loading on thrombus formation, suggesting that iron accelerated thrombosis through a pro-oxidant mechanism. Iron loading enhanced both systemic and vascular reactive oxygen species production. Endothelium- dependent vasorelaxation was impaired in iron-loaded mice, indicating reduced NO bioavailability. Conclusions Moderate iron loading markedly accelerates thrombus formation after arterial injury, increases vascular oxidative stress, and impairs vasoreactivity. Iron-induced vascular dysfunction may contribute to the increased incidence of ischemic cardiovascular events that have been associated with chronic iron overload. Key Words: thrombosis free radicals arteries Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > "Harvey R. Stone" <hrst...(a)swbell.net> wrote in messagenews:Dr3bk.6309$LG4.1736(a)nlpi065.nbdc.sbc.com...> Reported for being off topic in Alt.support..arthritis,,,, cross posting > > after being warned not to do it. > > > Path: > > nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy.com!nlpi057.nbdc.sbc.com!prodigy.net!border1.nntp.dca.giganews.com!nntp.giganews.com!postnews..google.com!l64g2000hse.googlegroups.com!not-for-mail > > From: ironjustice <teamtan...(a)hotmail.com> > > [snip] > Off topic in alt.support.diabetes too. Has ignored requests not to > post off topic messages there. > > Note that groups-ab...(a)google.com is slow and not very effective > at responding to reports of spam posted through Google groups, so > I would expect them to be unlikely to act on reports of being off topic. > However, it does help to report the same spammers over and over > for different messages for at least 6 weeks, so perhaps > groups-ab...(a)google.com just can't keep up with reading all their > incoming mail.
From: ironjustice on 3 Jul 2008 10:46 On Jul 3, 7:28 am, "Robert Miles" <robertmi...(a)bellsouthNOSPAM.net> wrote:[snip] Off topic in alt.support.diabetes too.<< Meet Robert .. he knows NOTHING about diabetes .. he only .. has diabetes. Through .. stupidity .. evidentally .. -------------------------------- Diabetes Raises the Risk of Thrombosis in Atheromatous Coronary Arteries A study was undertaken at the Massachusetts General Hospital to quantify the lipid composition and macrophage infiltration in atheromatous plaques of culprit coronary arteries removed from 47 patients diagnosed with diabetes who were subjected to atherectomy for acute ischemic events. Lesions were also studied from 48 nondiabetic patients matched clinically and demographically with the diabetic patients. Four types of tissue in atheromatous plaque were identified by staining: tissue with few cells and densely-stained collagen; tissue with abundant smooth muscle cells and a loose connective tissue matrix; lipid-rich atheroma with acellular debris, cholesterol clefts, and no preserved connective tissue matrix; and thrombus. It was found that lipid-rich atheroma and macrophages occupied larger percentages of total area of specimens from diabetic than nondiabetic patients. The incidence of thrombus was greater in diabetic than in nondiabetic subjects (62% vs 40%, P=0.04). Whether diabetic patients had been treated with insulin, a sulfonylurea, or diet had no effect on plaque composition, macrophage infiltration, or thrombus presence. The finding that coronary tissue from patients diagnosed with diabetes exhibits a larger content of lipid-rich atheroma, macrophage infiltration, and subsequent thrombosis than tissue from patients without diabetes suggests that diabetes increases vulnerability for coronary thrombosis. Moreno PR, Murcia AM, Palacios IF, et al. Coronary composition and macrophage infiltration in atherectomy specimens from patients with diabetes mellitus. Circulation. 2000;102:2180-2184. The above summary is adapted from the cited reference. -------------------------------------------------------------------------------- Additional Information Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis: Lack of Direct Growth-Promoting Effects of High Glucose Levels Cardiologists Should Become as Familiar With Diabetes as They Are With Dyslipidemia and Hypertension Coronary Atherosclerosis in Type 2 Diabetes: Angiographic Findings and Clinical Outcome Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > "Harvey R. Stone" <hrst...(a)swbell.net> wrote in messagenews:Dr3bk.6309$LG4.1736(a)nlpi065.nbdc.sbc.com...> Reported for being off topic in Alt.support..arthritis,,,, cross posting > > after being warned not to do it. > > > Path: > > nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy.com!nlpi057.nbdc.sbc.com!prodigy.net!border1.nntp.dca.giganews.com!nntp.giganews.com!postnews..google.com!l64g2000hse.googlegroups.com!not-for-mail > > From: ironjustice <teamtan...(a)hotmail.com> > > [snip] > Off topic in alt.support.diabetes too. Has ignored requests not to > post off topic messages there. > > Note that groups-ab...(a)google.com is slow and not very effective > at responding to reports of spam posted through Google groups, so > I would expect them to be unlikely to act on reports of being off topic. > However, it does help to report the same spammers over and over > for different messages for at least 6 weeks, so perhaps > groups-ab...(a)google.com just can't keep up with reading all their > incoming mail.
From: ironjustice on 3 Jul 2008 18:31 On Jul 3, 7:46 am, ironjustice <ironjust...(a)cashette.com> wrote: thrombosis << Increased red blood cells cause thrombosis. THAT is **precisely** WHY .. epo .. 'fell from grace'. Epo builds red blood cells and it causes .. thrombosis. Black Box Warning Ordered for Aranesp, Epogen, and Procrit By Peggy Peck, Managing Editor, MedPage Today Published: March 09, 2007 Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco Earn CME/CE credit for reading medical news http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/5231 ROCKVILLE, Md., March 9 -- The FDA warned today that aggressive use of erythropoiesis-stimulating agents to raise hemoglobin to a target of 12 g/dL or higher was associated with "serious and life-threatening side-effects and/or death." The warning states: Avoid serious cardiovascular and arterial and venous thromboembolic events by using the lowest dose of Aranesp, Epogen, or Procrit that will gradually raise the hemoglobin concentration to the lowest level sufficient to avoid the need for blood transfusion. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jul 3, 7:28 am, "Robert Miles" <robertmi...(a)bellsouthNOSPAM.net> > wrote:[snip] Off topic in alt.support.diabetes too.<< > > Meet Robert .. he knows NOTHING about diabetes .. he only .. has > diabetes. > Through .. stupidity .. evidentally .. > -------------------------------- > Diabetes Raises the Risk of Thrombosis in Atheromatous Coronary > Arteries > > A study was undertaken at the Massachusetts General Hospital to > quantify the lipid composition and macrophage infiltration in > atheromatous plaques of culprit coronary arteries removed from 47 > patients diagnosed with diabetes who were subjected to atherectomy for > acute ischemic events. Lesions were also studied from 48 nondiabetic > patients matched clinically and demographically with the diabetic > patients. > > Four types of tissue in atheromatous plaque were identified by > staining: tissue with few cells and densely-stained collagen; tissue > with abundant smooth muscle cells and a loose connective tissue > matrix; lipid-rich atheroma with acellular debris, cholesterol clefts, > and no preserved connective tissue matrix; and thrombus. > > It was found that lipid-rich atheroma and macrophages occupied larger > percentages of total area of specimens from diabetic than nondiabetic > patients. The incidence of thrombus was greater in diabetic than in > nondiabetic subjects (62% vs 40%, P=0.04). Whether diabetic patients > had been treated with insulin, a sulfonylurea, or diet had no effect > on plaque composition, macrophage infiltration, or thrombus presence. > > The finding that coronary tissue from patients diagnosed with diabetes > exhibits a larger content of lipid-rich atheroma, macrophage > infiltration, and subsequent thrombosis than tissue from patients > without diabetes suggests that diabetes increases vulnerability for > coronary thrombosis. > > Moreno PR, Murcia AM, Palacios IF, et al. Coronary composition and > macrophage infiltration in atherectomy specimens from patients with > diabetes mellitus. Circulation. 2000;102:2180-2184. > The above summary is adapted from the cited reference. > > -------------------------------------------------------------------------------- > Additional Information > Diabetes Accelerates Smooth Muscle Accumulation in Lesions of > Atherosclerosis: Lack of Direct Growth-Promoting Effects of High > Glucose Levels > > Cardiologists Should Become as Familiar With Diabetes as They Are > With Dyslipidemia and Hypertension > > Coronary Atherosclerosis in Type 2 Diabetes: Angiographic Findings > and Clinical Outcome > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > "Harvey R. Stone" <hrst...(a)swbell.net> wrote in messagenews:Dr3bk.6309$LG4.1736(a)nlpi065.nbdc.sbc.com...> Reported for being off topic in Alt.support.arthritis,,,, cross posting > > > after being warned not to do it. > > > > Path: > > > nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy.com!nlpi057.nbdc.sbc.com!prodigy.net!border1.nntp.dca.giganews.com!nntp.giganews.com!postnews.google.com!l64g2000hse.googlegroups.com!not-for-mail > > > From: ironjustice <teamtan...(a)hotmail.com> > > > [snip] > > Off topic in alt.support.diabetes too. Has ignored requests not to > > post off topic messages there. > > > Note that groups-ab...(a)google.com is slow and not very effective > > at responding to reports of spam posted through Google groups, so > > I would expect them to be unlikely to act on reports of being off topic.. > > However, it does help to report the same spammers over and over > > for different messages for at least 6 weeks, so perhaps > > groups-ab...(a)google.com just can't keep up with reading all their > > incoming mail.- Hide quoted text - > > - Show quoted text -
From: ironjustice on 3 Jul 2008 20:20
On Jul 3, 3:31 pm, ironjustice <ironjust...(a)cashette.com> wrote: thrombosis101 << http://tinyurl.com/5jjr3p Venous Thromboembolic Disease DEFINITION "Blood clot" Deep vein thrombosis (DVT) and pulmonary embolism represent different manifestations of the same clinical entity, which is referred to as venous thromboembolism. "Blood clot" In patients with this condition, venous thrombosis occurs when red blood cells, fibrin, and to a lesser extent platelets and leukocytes form a mass within an intact cardiovascular system. "Blood clot" A proximal DVT in the leg is one that is located within the popliteal, femoral (including the superficial femoral), or iliac veins. "Blood clot in lung" A pulmonary embolism occurs when a segment of a thrombus within the deep venous system detaches from the vessel, travels to the lungs, and lodges within the pulmonary arteries. "Blood clots in legs go to lungs and kill you" The pelvic and deep veins of the lower extremities are the source of more than 70% of all pulmonary emboli.1 "Blood clots in heart" The superior vena cava, upper extremity veins, and right chambers of the heart are less common sources. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jul 3, 7:46 am, ironjustice <ironjust...(a)cashette.com> wrote: > thrombosis << > > Increased red blood cells cause thrombosis. > THAT is **precisely** WHY .. epo .. 'fell from grace'. > Epo builds red blood cells and it causes .. thrombosis. > > Black Box Warning Ordered for Aranesp, Epogen, and Procrit > By Peggy Peck, Managing Editor, MedPage Today > Published: March 09, 2007 > Reviewed by Robert Jasmer, MD; Associate Clinical Professor of > Medicine, University of California, San Francisco Earn CME/CE credit > for reading medical news > > http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/5231 > > ROCKVILLE, Md., March 9 -- The FDA warned today that aggressive use of > erythropoiesis-stimulating agents to raise hemoglobin to a target of > 12 g/dL or higher was associated with "serious and life-threatening > side-effects and/or death." > > The warning states: > > Avoid serious cardiovascular and arterial and venous thromboembolic > events by using the lowest dose of Aranesp, Epogen, or Procrit that > will gradually raise the hemoglobin concentration to the lowest level > sufficient to avoid the need for blood transfusion. > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jul 3, 7:28 am, "Robert Miles" <robertmi...(a)bellsouthNOSPAM.net> > > wrote:[snip] Off topic in alt.support.diabetes too.<< > > > Meet Robert .. he knows NOTHING about diabetes .. he only .. has > > diabetes. > > Through .. stupidity .. evidentally .. > > -------------------------------- > > Diabetes Raises the Risk of Thrombosis in Atheromatous Coronary > > Arteries > > > A study was undertaken at the Massachusetts General Hospital to > > quantify the lipid composition and macrophage infiltration in > > atheromatous plaques of culprit coronary arteries removed from 47 > > patients diagnosed with diabetes who were subjected to atherectomy for > > acute ischemic events. Lesions were also studied from 48 nondiabetic > > patients matched clinically and demographically with the diabetic > > patients. > > > Four types of tissue in atheromatous plaque were identified by > > staining: tissue with few cells and densely-stained collagen; tissue > > with abundant smooth muscle cells and a loose connective tissue > > matrix; lipid-rich atheroma with acellular debris, cholesterol clefts, > > and no preserved connective tissue matrix; and thrombus. > > > It was found that lipid-rich atheroma and macrophages occupied larger > > percentages of total area of specimens from diabetic than nondiabetic > > patients. The incidence of thrombus was greater in diabetic than in > > nondiabetic subjects (62% vs 40%, P=0.04). Whether diabetic patients > > had been treated with insulin, a sulfonylurea, or diet had no effect > > on plaque composition, macrophage infiltration, or thrombus presence. > > > The finding that coronary tissue from patients diagnosed with diabetes > > exhibits a larger content of lipid-rich atheroma, macrophage > > infiltration, and subsequent thrombosis than tissue from patients > > without diabetes suggests that diabetes increases vulnerability for > > coronary thrombosis. > > > Moreno PR, Murcia AM, Palacios IF, et al. Coronary composition and > > macrophage infiltration in atherectomy specimens from patients with > > diabetes mellitus. Circulation. 2000;102:2180-2184. > > The above summary is adapted from the cited reference. > > > -------------------------------------------------------------------------------- > > Additional Information > > Diabetes Accelerates Smooth Muscle Accumulation in Lesions of > > Atherosclerosis: Lack of Direct Growth-Promoting Effects of High > > Glucose Levels > > > Cardiologists Should Become as Familiar With Diabetes as They Are > > With Dyslipidemia and Hypertension > > > Coronary Atherosclerosis in Type 2 Diabetes: Angiographic Findings > > and Clinical Outcome > > > Who loves ya. > > Tom > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > "Harvey R. Stone" <hrst...(a)swbell.net> wrote in messagenews:Dr3bk.6309$LG4.1736(a)nlpi065.nbdc.sbc.com...> Reported for being off topic in Alt.support.arthritis,,,, cross posting > > > > after being warned not to do it. > > > > > Path: > > > > nlpi059.nbdc.sbc.com!nlpi062.nbdc.sbc.com!prodigy.com!nlpi057.nbdc.sbc.com!prodigy.net!border1.nntp.dca.giganews.com!nntp.giganews.com!postnews.google.com!l64g2000hse.googlegroups.com!not-for-mail > > > > From: ironjustice <teamtan...(a)hotmail.com> > > > > [snip] > > > Off topic in alt.support.diabetes too. Has ignored requests not to > > > post off topic messages there. > > > > Note that groups-ab...(a)google.com is slow and not very effective > > > at responding to reports of spam posted through Google groups, so > > > I would expect them to be unlikely to act on reports of being off topic. > > > However, it does help to report the same spammers over and over > > > for different messages for at least 6 weeks, so perhaps > > > groups-ab...(a)google.com just can't keep up with reading all their > > > incoming mail.- Hide quoted text - > > > - Show quoted text -- Hide quoted text - > > - Show quoted text - |