Phlebotomy Prevents Thrombosis
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From: ironjustice on 30 Jun 2008 11:14 On Jun 30, 7:50 am, ironjustice <ironjust...(a)cashette.com> wrote: thrombosis << http://www.guideline.gov/summary/summary.aspx?doc_id=11995 Brief Summary GUIDELINE TITLE Guideline for the diagnosis, investigation and management of polycythaemia/erythrocytosis. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jun 30, 7:17 am, ironjustice <ironjust...(a)cashette.com> wrote: > thrombosis << > > http://tinyurl.com/64dl79 > > Treatment: > The objective of treatment is to reduce the high blood viscosity > (thickness of the blood) due to the increased red blood cell mass and > to prevent hemorrhage and thrombosis. > > Phlebotomy is one method used to reduce the high blood viscosity. In > phlebotomy, 1 unit (pint) of blood is removed weekly until the > hematocrit is less than 45, then phlebotomy is continued as necessary. > > Occasionally, chemotherapy may be given to suppress the bone marrow. > > The use of anti-platelet therapy (such as aspirin) is controversial > because it may cause gastric bleeding. > > Allopurinol is given for hyperuricemia (gout). > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 6:56 am, ironjustice <ironjust...(a)cashette.com> wrote: > > thrombosis << > > >http://qjmed.oxfordjournals.org/cgi/content/full/93/8/497 > > > Q J Med 2000; 93: 497-499 > > © 2000 Association of Physicians > > > -------------------------------------------------------------------------------- > > > Editorial > > > Warfarin for multiple sclerosis? > > > "Today, almost 20 years later, there are enough data to consider > > antiphospholipid syndrome (APS), or Hughes' syndrome, as a major > > differential in the diagnosis of definite or probable MS according to > > Poser's criteria. > > > Arterial thrombosis is a major feature of Hughes' syndrome, central > > nervous system vessels being among the most frequently affected" > > > Who loves ya. > > Tom > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > On Jun 30, 6:48 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > thrombosis << > > > > "Phlebotomy to reduce the red cell mass is of prime importance" > > > > http://www.medscape.com/viewarticle/468404_2 > > > > Who loves ya. > > > Tom > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > The thread is .. thrombosis .. > > > > > Thrombosis ..http://en.wikipedia.org/wiki/Thrombosis > > > > > Read what thrombosis .. is .. > > > > > BE .. thrombosis .. > > > > > Say **something** .. about .. **thrombosis** .. > > > > > Or .. ? .. stay off **my** thread .. > > > > > Too hard for you to understand .. ? > > > > > Heh .. heh .. > > > > > Must make me .. dangerous .. > > > > > Who loves ya. > > > > Tom > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > > > > DEAD PEOPLE WALKING > > > > http://tinyurl.com/zk9fk > > > > > > ROFL!!! Tommy, mr rustbucket spammer troll, you have no clue what so > > > > > ever of what I or anyone else knows. > > > > > > You KNOW that flooding multiple news groups with the same posts over and > > > > > over and over and over again is against most all ISP's terms of service. > > > > > You still do it whether it has anything to do with the group or not! > > > > > YOU are the stupid one, but then you already know that and so does > > > > > everyone else! > > > > > > Is it really necessary to keep posting the same thing over and over and > > > > > over again? Of course not, but since you are a dangerous spammer troll > > > > > who practices medicine without a license, advertises commercial sites, > > > > > and practices dangerous breaches of terms of service, you obviously have > > > > > no regard or concern for any human life. > > > > > > When proven wrong, you resort to name calling and foul > > > > > language---further proof of who you are and what you are! Sad, so very > > > > > sad. > > > > > . > > > > > . > > > > > . > > > > > . > > > > > .- Hide quoted text - > > > > > - Show quoted text -- Hide quoted text - > > > > - Show quoted text -- Hide quoted text - > > > - Show quoted text -- Hide quoted text - > > - Show quoted text -
From: ironjustice on 30 Jun 2008 11:25 On Jun 30, 8:14 am, ironjustice <ironjust...(a)cashette.com> wrote: Guideline for the diagnosis, investigation and management of polycythaemia/erythrocytosis. << "Advise reduction or elimination of factors which may contribute to apparent erythrocytosis" This is where we lose .. 'them' .. They fail to adhere to this .. STANDARD OF CARE .. Some tell us not to go near .. meat .. when we take antibiotics because OF .. ? .. iron .. Iron is KNOWN to increase red blood cell production. THAT is why they inject iron INTO .. you. Isn't .. it .. ? Well .. isn't it .. ? They don't tell you not to go near high iron foods .. do they .. Now .. WHY .. is that .. ? WHY wouldn't they tell us that "INCREASED IRON CAUSES INCREASED RED BLOOD CELL PRODUCTION" .. They don't know .. that .. ? They are chickensht sonsabtches .. ? Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jun 30, 7:50 am, ironjustice <ironjust...(a)cashette.com> wrote: > thrombosis << > > http://www.guideline.gov/summary/summary.aspx?doc_id=11995 > > Brief Summary > GUIDELINE TITLE > Guideline for the diagnosis, investigation and management of > polycythaemia/erythrocytosis. > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 7:17 am, ironjustice <ironjust...(a)cashette.com> wrote: > > thrombosis << > > >http://tinyurl.com/64dl79 > > > Treatment: > > The objective of treatment is to reduce the high blood viscosity > > (thickness of the blood) due to the increased red blood cell mass and > > to prevent hemorrhage and thrombosis. > > > Phlebotomy is one method used to reduce the high blood viscosity. In > > phlebotomy, 1 unit (pint) of blood is removed weekly until the > > hematocrit is less than 45, then phlebotomy is continued as necessary. > > > Occasionally, chemotherapy may be given to suppress the bone marrow. > > > The use of anti-platelet therapy (such as aspirin) is controversial > > because it may cause gastric bleeding. > > > Allopurinol is given for hyperuricemia (gout). > > > Who loves ya. > > Tom > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > On Jun 30, 6:56 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > thrombosis << > > > >http://qjmed.oxfordjournals.org/cgi/content/full/93/8/497 > > > > Q J Med 2000; 93: 497-499 > > > © 2000 Association of Physicians > > > > -------------------------------------------------------------------------------- > > > > Editorial > > > > Warfarin for multiple sclerosis? > > > > "Today, almost 20 years later, there are enough data to consider > > > antiphospholipid syndrome (APS), or Hughes' syndrome, as a major > > > differential in the diagnosis of definite or probable MS according to > > > Poser's criteria. > > > > Arterial thrombosis is a major feature of Hughes' syndrome, central > > > nervous system vessels being among the most frequently affected" > > > > Who loves ya. > > > Tom > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 6:48 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > thrombosis << > > > > > "Phlebotomy to reduce the red cell mass is of prime importance" > > > > > http://www.medscape.com/viewarticle/468404_2 > > > > > Who loves ya. > > > > Tom > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > The thread is .. thrombosis .. > > > > > > Thrombosis ..http://en.wikipedia.org/wiki/Thrombosis > > > > > > Read what thrombosis .. is .. > > > > > > BE .. thrombosis .. > > > > > > Say **something** .. about .. **thrombosis** .. > > > > > > Or .. ? .. stay off **my** thread .. > > > > > > Too hard for you to understand .. ? > > > > > > Heh .. heh .. > > > > > > Must make me .. dangerous .. > > > > > > Who loves ya. > > > > > Tom > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > > > > > DEAD PEOPLE WALKING > > > > > http://tinyurl.com/zk9fk > > > > > > > ROFL!!! Tommy, mr rustbucket spammer troll, you have no clue what so > > > > > > ever of what I or anyone else knows. > > > > > > > You KNOW that flooding multiple news groups with the same posts over and > > > > > > over and over and over again is against most all ISP's terms of service. > > > > > > You still do it whether it has anything to do with the group or not! > > > > > > YOU are the stupid one, but then you already know that and so does > > > > > > everyone else! > > > > > > > Is it really necessary to keep posting the same thing over and over and > > > > > > over again? Of course not, but since you are a dangerous spammer troll > > > > > > who practices medicine without a license, advertises commercial sites, > > > > > > and practices dangerous breaches of terms of service, you obviously have > > > > > > no regard or concern for any human life. > > > > > > > When proven wrong, you resort to name calling and foul > > > > > > language---further proof of who you are and what you are! Sad, so very > > > > > > sad. > > > > > > . > > > > > > . > > > > > > . > > > > > > . > > > > > > .- Hide quoted text - > > > > > > - Show quoted text -- Hide quoted text - > > > > > - Show quoted text -- Hide quoted text - > > > > - Show quoted text -- Hide quoted text - > > > - Show quoted text -- Hide quoted text - > > - Show quoted text -
From: ironjustice on 30 Jun 2008 11:39 On Jun 30, 8:25 am, ironjustice <ironjust...(a)cashette.com> wrote: INCREASED IRON CAUSES INCREASED RED BLOOD CELL PRODUCTION << http://www.merck.com/mmpe/sec11/ch130/ch130b.html "Iron absorption is best when food contains heme iron (meat). Dietary nonheme iron must be reduced to the ferrous state and released from food binders by gastric secretions. Nonheme iron absorption is reduced by other food items (eg, vegetable fiber phytates and polyphenols; tea tannates, including phosphoproteins; bran) and certain antibiotics (eg, tetracycline). Ascorbic acid is the only common food element known to increase nonheme iron absorption." They didn't mention vitamin C also causes heme iron absorption to rise. Sooo .. your glass of OJ (hi Gene) in the morning WITH your bacon / heme iron .. is gonna give you a jolt of iron which should last you for a week .. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jun 30, 8:14 am, ironjustice <ironjust...(a)cashette.com> wrote: > Guideline for the diagnosis, investigation and management of > polycythaemia/erythrocytosis. << > > "Advise reduction or elimination of factors which may contribute to > apparent erythrocytosis" > > This is where we lose .. 'them' .. > > They fail to adhere to this .. STANDARD OF CARE .. > > Some tell us not to go near .. meat .. when we take antibiotics > because OF .. ? .. iron .. > > Iron is KNOWN to increase red blood cell production. > > THAT is why they inject iron INTO .. you. > > Isn't .. it .. ? > > Well .. isn't it .. ? > > They don't tell you not to go near high iron foods .. do they .. > > Now .. WHY .. is that .. ? > > WHY wouldn't they tell us that "INCREASED IRON CAUSES INCREASED RED > BLOOD CELL PRODUCTION" .. > > They don't know .. that .. ? > > They are chickensht sonsabtches .. ? > > Heh .. heh .. > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 7:50 am, ironjustice <ironjust...(a)cashette.com> wrote: > > thrombosis << > > >http://www.guideline.gov/summary/summary.aspx?doc_id=11995 > > > Brief Summary > > GUIDELINE TITLE > > Guideline for the diagnosis, investigation and management of > > polycythaemia/erythrocytosis. > > > Who loves ya. > > Tom > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > On Jun 30, 7:17 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > thrombosis << > > > >http://tinyurl.com/64dl79 > > > > Treatment: > > > The objective of treatment is to reduce the high blood viscosity > > > (thickness of the blood) due to the increased red blood cell mass and > > > to prevent hemorrhage and thrombosis. > > > > Phlebotomy is one method used to reduce the high blood viscosity. In > > > phlebotomy, 1 unit (pint) of blood is removed weekly until the > > > hematocrit is less than 45, then phlebotomy is continued as necessary. > > > > Occasionally, chemotherapy may be given to suppress the bone marrow. > > > > The use of anti-platelet therapy (such as aspirin) is controversial > > > because it may cause gastric bleeding. > > > > Allopurinol is given for hyperuricemia (gout). > > > > Who loves ya. > > > Tom > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 6:56 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > thrombosis << > > > > >http://qjmed.oxfordjournals.org/cgi/content/full/93/8/497 > > > > > Q J Med 2000; 93: 497-499 > > > > © 2000 Association of Physicians > > > > > -------------------------------------------------------------------------------- > > > > > Editorial > > > > > Warfarin for multiple sclerosis? > > > > > "Today, almost 20 years later, there are enough data to consider > > > > antiphospholipid syndrome (APS), or Hughes' syndrome, as a major > > > > differential in the diagnosis of definite or probable MS according to > > > > Poser's criteria. > > > > > Arterial thrombosis is a major feature of Hughes' syndrome, central > > > > nervous system vessels being among the most frequently affected" > > > > > Who loves ya. > > > > Tom > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > On Jun 30, 6:48 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > > thrombosis << > > > > > > "Phlebotomy to reduce the red cell mass is of prime importance" > > > > > > http://www.medscape.com/viewarticle/468404_2 > > > > > > Who loves ya. > > > > > Tom > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > > The thread is .. thrombosis .. > > > > > > > Thrombosis ..http://en.wikipedia.org/wiki/Thrombosis > > > > > > > Read what thrombosis .. is .. > > > > > > > BE .. thrombosis .. > > > > > > > Say **something** .. about .. **thrombosis** .. > > > > > > > Or .. ? .. stay off **my** thread .. > > > > > > > Too hard for you to understand .. ? > > > > > > > Heh .. heh .. > > > > > > > Must make me .. dangerous .. > > > > > > > Who loves ya. > > > > > > Tom > > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > > > > > > DEAD PEOPLE WALKING > > > > > > http://tinyurl.com/zk9fk > > > > > > > > ROFL!!! Tommy, mr rustbucket spammer troll, you have no clue what so > > > > > > > ever of what I or anyone else knows. > > > > > > > > You KNOW that flooding multiple news groups with the same posts over and > > > > > > > over and over and over again is against most all ISP's terms of service. > > > > > > > You still do it whether it has anything to do with the group or not! > > > > > > > YOU are the stupid one, but then you already know that and so does > > > > > > > everyone else! > > > > > > > > Is it really necessary to keep posting the same thing over and over and > > > > > > > over again? Of course not, but since you are a dangerous spammer troll > > > > > > > who practices medicine without a license, advertises commercial sites, > > > > > > > and practices dangerous breaches of terms of service, you obviously have > > > > > > > no regard or concern for any human life. > > > > > > > > When proven wrong, you resort to name calling and foul > > > > > > > language---further proof of who you are and what you are! Sad, so very > > > > > > > sad. > > > > > > > . > > > > > > > . > > > > > > > . > > > > > > > . > > > > > > > .- Hide quoted text - > > > > > > > - Show quoted text -- Hide quoted text - > > > > > > - Show quoted text -- Hide quoted text - > > > > > - Show quoted text -- Hide quoted text - > > > > - Show quoted text -- Hide quoted text - > > > - Show quoted text -- Hide quoted text - > > - Show quoted text -
From: ironjustice on 30 Jun 2008 12:01 On Jun 30, 8:39 am, ironjustice <ironjust...(a)cashette.com> wrote: elevated serum homocysteine << Silent Cerebral Infarction Reported in 10% of Healthy People DALLAS -- June 26, 2008 -- A recent study found that about 10% of the apparently healthy middle-aged participants with no symptoms of stroke were injured from silent cerebral infarction (SCI) researchers report in Stroke: Journal of the American Heart Association. "The findings reinforce the need for early detection and treatment of cardiovascular risk factors in midlife," said co-author of the study, Sudha Seshadri, MD, Boston University School of Medicine, Boston, Massachusetts. "This is especially true since SCIs have been associated with an increased risk of incident stroke and cognitive impairment." Researchers evaluated magnetic resonance imaging (MRI) from about 2,000 people aged an average of 62 years, who are part of the Framingham Offspring Study. Among patients who displayed no symptoms of stroke, 10.7% had SCIs on routine brain MRI, researchers said. Previous estimates of SCIs ranged from 5.8% to 17.7% depending on age, ethnicity, and other issues. Of those in the study with SCIs, 84% had a single lesion. The study is the first to correlate the total score of the Framingham Stroke Risk Profile to prevalence of SCI. All the components of the Framingham Stroke Risk Profile were positively associated with an increased prevalence of SCI. Also for the first time, researchers found a significant correlation between atrial fibrillation (AF) and silent cerebral infarction. High systolic blood pressure, hypertension, and elevated levels of blood homocysteine, were other risk factors commonly associated with stroke that also raised participants' chances of having SCI. "In our data, AF increased the risk of prevalent SCI more than 2- fold," said Dr. Seshadri. "The significant relationship between hypertension, elevated serum homocysteine, carotid artery disease, and prevalent SCI underscores the importance of current guidelines for the early diagnosis and prevention of hypertension and atherosclerosis and their risk factors." Unfortunately, the observational data could not indicate if screening for, and appropriately treating AF, would reduce the population burden of silent stroke, researchers said. SOURCE: American Heart Association Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jun 30, 8:25 am, ironjustice <ironjust...(a)cashette.com> wrote: > INCREASED IRON CAUSES INCREASED RED BLOOD CELL PRODUCTION << > > http://www.merck.com/mmpe/sec11/ch130/ch130b.html > > "Iron absorption is best when food contains heme iron (meat). Dietary > nonheme iron must be reduced to the ferrous state and released from > food binders by gastric secretions. Nonheme iron absorption is reduced > by other food items (eg, vegetable fiber phytates and polyphenols; tea > tannates, including phosphoproteins; bran) and certain antibiotics > (eg, tetracycline). Ascorbic acid is the only common food element > known to increase nonheme iron absorption." > > They didn't mention vitamin C also causes heme iron absorption to > rise. > Sooo .. your glass of OJ (hi Gene) in the morning WITH your bacon / > heme iron .. is gonna give you a jolt of iron which should last you > for a week .. > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 8:14 am, ironjustice <ironjust...(a)cashette.com> wrote: > > Guideline for the diagnosis, investigation and management of > > polycythaemia/erythrocytosis. << > > > "Advise reduction or elimination of factors which may contribute to > > apparent erythrocytosis" > > > This is where we lose .. 'them' .. > > > They fail to adhere to this .. STANDARD OF CARE .. > > > Some tell us not to go near .. meat .. when we take antibiotics > > because OF .. ? .. iron .. > > > Iron is KNOWN to increase red blood cell production. > > > THAT is why they inject iron INTO .. you. > > > Isn't .. it .. ? > > > Well .. isn't it .. ? > > > They don't tell you not to go near high iron foods .. do they .. > > > Now .. WHY .. is that .. ? > > > WHY wouldn't they tell us that "INCREASED IRON CAUSES INCREASED RED > > BLOOD CELL PRODUCTION" .. > > > They don't know .. that .. ? > > > They are chickensht sonsabtches .. ? > > > Heh .. heh .. > > > Who loves ya. > > Tom > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > On Jun 30, 7:50 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > thrombosis << > > > >http://www.guideline.gov/summary/summary.aspx?doc_id=11995 > > > > Brief Summary > > > GUIDELINE TITLE > > > Guideline for the diagnosis, investigation and management of > > > polycythaemia/erythrocytosis. > > > > Who loves ya. > > > Tom > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 7:17 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > thrombosis << > > > > >http://tinyurl.com/64dl79 > > > > > Treatment: > > > > The objective of treatment is to reduce the high blood viscosity > > > > (thickness of the blood) due to the increased red blood cell mass and > > > > to prevent hemorrhage and thrombosis. > > > > > Phlebotomy is one method used to reduce the high blood viscosity. In > > > > phlebotomy, 1 unit (pint) of blood is removed weekly until the > > > > hematocrit is less than 45, then phlebotomy is continued as necessary. > > > > > Occasionally, chemotherapy may be given to suppress the bone marrow.. > > > > > The use of anti-platelet therapy (such as aspirin) is controversial > > > > because it may cause gastric bleeding. > > > > > Allopurinol is given for hyperuricemia (gout). > > > > > Who loves ya. > > > > Tom > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > On Jun 30, 6:56 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > > thrombosis << > > > > > >http://qjmed.oxfordjournals.org/cgi/content/full/93/8/497 > > > > > > Q J Med 2000; 93: 497-499 > > > > > © 2000 Association of Physicians > > > > > > -------------------------------------------------------------------------------- > > > > > > Editorial > > > > > > Warfarin for multiple sclerosis? > > > > > > "Today, almost 20 years later, there are enough data to consider > > > > > antiphospholipid syndrome (APS), or Hughes' syndrome, as a major > > > > > differential in the diagnosis of definite or probable MS according to > > > > > Poser's criteria. > > > > > > Arterial thrombosis is a major feature of Hughes' syndrome, central > > > > > nervous system vessels being among the most frequently affected" > > > > > > Who loves ya. > > > > > Tom > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > > On Jun 30, 6:48 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > > > thrombosis << > > > > > > > "Phlebotomy to reduce the red cell mass is of prime importance" > > > > > > > http://www.medscape.com/viewarticle/468404_2 > > > > > > > Who loves ya. > > > > > > Tom > > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > > > The thread is .. thrombosis .. > > > > > > > > Thrombosis ..http://en.wikipedia.org/wiki/Thrombosis > > > > > > > > Read what thrombosis .. is .. > > > > > > > > BE .. thrombosis .. > > > > > > > > Say **something** .. about .. **thrombosis** .. > > > > > > > > Or .. ? .. stay off **my** thread .. > > > > > > > > Too hard for you to understand .. ? > > > > > > > > Heh .. heh .. > > > > > > > > Must make me .. dangerous .. > > > > > > > > Who loves ya. > > > > > > > Tom > > > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > > > > > > > DEAD PEOPLE WALKING > > > > > > > http://tinyurl.com/zk9fk > > > > > > > > > ROFL!!! Tommy, mr rustbucket spammer troll, you have no clue what so > > > > > > > > ever of what I or anyone else knows. > > > > > > > > > You KNOW that flooding multiple news groups with the same posts over and > > > > > > > > over and over and over again is against most all ISP's terms of service. > > > > > > > > You still do it whether it has anything to do with the group or not! > > > > > > > > YOU are the stupid one, but then you already know that and so does > > > > > > > > everyone else! > > > > > > > > > Is it really necessary to keep posting the same thing over and over and > > > > > > > > over again? Of course not, but since you are a dangerous spammer troll > > > > > > > > who practices medicine without a license, advertises commercial sites, > > > > > > > > and practices dangerous breaches of terms of service, you obviously have > > > > > > > > no regard or concern for any human life. > > > > > > > > > When proven wrong, you resort to name calling and foul > > > > > > > > language---further proof of who you are and what you are! Sad, so very > > > > > > > > sad. > > > > > > > > . > > > > > > > > . > > > > > > > > . > > > > > > > > . > > > > > > > > .- Hide quoted text - > > > > > > > > - Show quoted text -- Hide quoted text - > > > > > > > - Show quoted text -- Hide quoted text - > > > > > > - Show quoted text -- Hide quoted text - > > > > > - Show quoted text -- Hide quoted text - > > > > - Show quoted text -- Hide quoted text - > > > - Show quoted text -- Hide quoted text - > > - Show quoted text -
From: ironjustice on 30 Jun 2008 13:19
On Jun 30, 9:01 am, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: Imatinib mesylate << Isn't this special that the drug used to treat **polycythemia** is also VERY effective in arthritis .. lupus .. diabetes .. multiple sclerosis .. ? "Imatinib mesylate produces 75% lasting remissions in polycythemia" Nihon Rinsho Meneki Gakkai Kaishi. 2007 Jun ;30 (3):165-73 17603257 (P,S,E,B) Imatinib mesylate as a novel therapeutic drug for systemic rheumatic diseases. [My paper] Hideto Kameda Division of Rheumatology/Clinical Immunology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University. Platelet-derived growth factor (PDGF) is a topic in the pathophysiology of various systemic rheumatic diseases. For example, autoantibody against PDGF receptor was identified in patients with systemic sclerosis. Imatinib mesylate has been well tolerable and widely used for chronic myeloid leukemia and gastrointestinal stromal tomor. Imatinib also inhibits the activation of c-Abl, which is a key downstream molecule of transforming growth factor-beta signaling, and PDGF receptors. Thus, imatinib effectively suppresses the activation and proliferation of fibroblasts, mesangial cells and smooth muscle cells. Therefore, imatinib may overcome the limitation of current therapeutic strategy with corticosteroids and immunosuppressive agents for refractory diseases ------------------------------- Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice Journal Modern Rheumatology ORIGINAL ARTICLE Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice Kensuke Koyama1, 2 , Kyosuke Hatsushika1, Takashi Ando1, Michitomo Sakuma1, Masanori Wako1, Ryohei Kato3, Hirotaka Haro2, Hajime Sugiyama2, Yoshiki Hamada2, Hideoki Ogawa4 and Atsuhito Nakao1, 4 (1) Department of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan (2) Department of Orthopaedic Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan (3) Department of Human Pathology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan (4) Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan Received: 08 February 2007 Accepted: 01 May 2007 Published online: 20 August 2007 Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease that is associated with joint destruction. Imatinib mesylate (imatinib) is an inhibitor that specifically targets a set of protein tyrosine kinase, such as abl, c-kit, and platelet- derived growth factor receptor (PDGFR) and it is widely used to treat chronic myeloid leukemia (CML). The purpose of the present study is to determine whether imatinib can provide benefit in the arthritis induced by anti-collagen type II antibody (CAIA) in mice, a model that provides an opportunity to study the effector inflammatory phase of arthritis without involving the priming phase of the immune responses. Mice treated with intraperitoneal administration of imatinib (1 or 10 mg/kg) prior to the development of CAIA displayed significant reductions in the severity of CAIA as assessed by arthritis score, histology, and synovial PDGF and vascular endothelial growth factor expression. In addition, treatment of the mice that had developed CAIA with intraperitoneal administration of imatinib (1 or 10âmg/kg) inhibited the progression of arthritis as assessed by those parameters. These results suggest that imatinib prevents and treats CAIA. Imatinib may thus have both a preventive and therapeutic potential for the joint inflammation at the effector stage of RA. Key words Anti-collagen type II antibody-induced arthritis (CAIA) - Imatinib mesylate - Rheumatoid arthritis Kensuke Koyama Email: vesupanomusuko(a)yahoo.co.jp -------------------------------------------------------------------------------- Update on the treatment of polycythemia vera with recombinant interferon alfa or imatinib mesylate Journal Current Hematologic Malignancy Reports Update on the treatment of polycythemia vera with recombinant interferon alfa or imatinib mesylate Richard T. Silver1 (1) New York-Presbyterian Hospital/Weill Cornell Medical Center, 1300 York Avenue, Box 581, New York, NY 10021, USA Published online: 15 April 2007 Abstract Polycythemia vera is a myeloproliferative disease, which, if untreated, leads to thrombohemorrhagic complications and eventually to progressive myelofibrosis, anemia, and splenomegaly. Two newly available drugs, interferon alfa and imatinib mesylate, may alter the course of this disease. Used as single agents, each produces lasting remissions in about 75% of patients with polycythemia vera. Of significance, change in JAK2 expression has been reported after treatment with both agents. Richard T. Silver Email: rtsilve(a)med.cornell.edu Publisher Current Medicine Group LLC ISSN 1558-8211 (Print) 1558-822X (Online) Issue Volume 2, Number 1 / February, 2007 DOI 10.1007/s11899-007-0006-2 -------------------------------------------------------------------------------- Published as doi: 10.1096/fj.06-6910com. (The FASEB Journal. 2007;21:618-628.) © 2007 FASEB Amelioration of diabetes by imatinib mesylate (Gleevec®): role of Ã- cell NF-B activation and anti-apoptotic preconditioning Robert Hägerkvist, Stellan Sandler, Dariush Mokhtari and Nils Welsh Department of Medical Cell Biology, Uppsala University, Biomedicum, Uppsala, Sweden 1Correspondence: Department of Medical Cell Biology, Uppsala University, Biomedicum, P.O. Box 571, SE-75123 Uppsala, Sweden. E- mail: Nils.Welsh(a)medcellbiol.uu.se06-6910com It was recently reported that tyrosine kinase inhibitor imatinib mesylate (Gleevec®) improves Type 2 diabetes, possibly by decreasing insulin resistance. However, as both Type 2 and Type 1 diabetes are characterized by Ã- cell dysfunction and death, we investigated whether imatinib counteracts diabetes by maintaining Ã-cell function. We observed that imatinib counteracted diabetes in two animal models, the streptozotocin-injected mouse and the nonobese diabetes mouse, and that this was paralleled by a partial preservation of the Ã-cell mass. In addition, imatinib decreased the death of human Ã-cells in vitro when exposed to NO, cytokines, and streptozotocin. The imatinib effect was mimicked by siRNA-mediated knockdown of c-Abl mRNA. Imatinib enhanced Ã-cell survival by promoting a state similar to ischemic preconditioning, as evidenced by NF-B activation, increased NO and reactive oxygen species production, and depolarization of the inner mitochondrial membrane. Imatinib did not suppress islet cell death in the presence of an NF-B inhibitor, suggesting that NF-B activation is a necessary step in the antiapoptotic action of imatinib. We conclude that imatinib mediates Ã-cell survival and that this could contribute to the beneficial effects observed in diabetes. âHägerkvist, R., Sandler, S., Mokhtari, D., Welsh, N. Amelioration of diabetes by imatinib mesylate (Gleevec®): role of Ã-cell NF-B activation and anti-apoptotic preconditioning. Key Words: pancreatic islet ⢠c-Abl ⢠NO -------------------------- http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1564430 In addition to potentially providing benefit in RA, it is anticipated that imatinib could also provide efficacy in other autoimmune diseases. A patient with psoriasis exhibited clinical improvement following treatment with imatinib for a concomitant malignancy (55). Imatinib ameliorated glomerulonephritis in MRL/lpr mice, and this effect was attributed to inhibition of PDGFR (56). Mast cells, which are potently inhibited by imatinib, have been suggested to contribute to pathogenesis of multiple sclerosis, autoimmune skin diseases, and inflammatory bowel disease (15). TNF-α is a driver of autoimmune tissue injury in a spectrum of autoimmune diseases, including RA, Crohn disease, psoriasis, and multiple sclerosis (57). Although imatinib-mediated inhibition of macrophage TNF-α production, mast cell activation and TNF-α release, and autoreactive B and T lymphocyte activation could provide benefit in many autoimmune diseases, imatinibâs ability to inhibit PDGFR makes it particularly suited for the treatment of RA and other diseases in which fibrotic processes play a central role in pathogenesis. In conclusion, we have shown that imatinib potently treats CIA and inhibits multiple signal transduction pathways that drive pathogenic cellular responses in RA. Our results provide further rationale for prospective clinical trials to determine whether imatinib provides efficacy in RA and other autoimmune diseases. Selective tyrosine kinase inhibition by imatinib and other pharmacologic agents (58) represents a promising and powerful strategy for the treatment of RA and other inflammatory diseases. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > On Jun 30, 8:39 am, ironjustice <ironjust...(a)cashette.com> wrote: > elevated serum homocysteine << > > Silent Cerebral Infarction Reported in 10% of Healthy People > > DALLAS -- June 26, 2008 -- A recent study found that about 10% of the > apparently healthy middle-aged participants with no symptoms of stroke > were injured from silent cerebral infarction (SCI) researchers report > in Stroke: Journal of the American Heart Association. > > "The findings reinforce the need for early detection and treatment of > cardiovascular risk factors in midlife," said co-author of the study, > Sudha Seshadri, MD, Boston University School of Medicine, Boston, > Massachusetts. "This is especially true since SCIs have been > associated with an increased risk of incident stroke and cognitive > impairment." > > Researchers evaluated magnetic resonance imaging (MRI) from about > 2,000 people aged an average of 62 years, who are part of the > Framingham Offspring Study. Among patients who displayed no symptoms > of stroke, 10.7% had SCIs on routine brain MRI, researchers said. > Previous estimates of SCIs ranged from 5.8% to 17.7% depending on age, > ethnicity, and other issues. Of those in the study with SCIs, 84% had > a single lesion. > > The study is the first to correlate the total score of the Framingham > Stroke Risk Profile to prevalence of SCI. All the components of the > Framingham Stroke Risk Profile were positively associated with an > increased prevalence of SCI. Also for the first time, researchers > found a significant correlation between atrial fibrillation (AF) and > silent cerebral infarction. High systolic blood pressure, > hypertension, and elevated levels of blood homocysteine, were other > risk factors commonly associated with stroke that also raised > participants' chances of having SCI. > > "In our data, AF increased the risk of prevalent SCI more than 2- > fold," said Dr. Seshadri. "The significant relationship between > hypertension, elevated serum homocysteine, carotid artery disease, and > prevalent SCI underscores the importance of current guidelines for the > early diagnosis and prevention of hypertension and atherosclerosis and > their risk factors." > > Unfortunately, the observational data could not indicate if screening > for, and appropriately treating AF, would reduce the population burden > of silent stroke, researchers said. > > SOURCE: American Heart Association > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 8:25 am, ironjustice <ironjust...(a)cashette.com> wrote: > > INCREASED IRON CAUSES INCREASED RED BLOOD CELL PRODUCTION << > > >http://www.merck.com/mmpe/sec11/ch130/ch130b.html > > > "Iron absorption is best when food contains heme iron (meat). Dietary > > nonheme iron must be reduced to the ferrous state and released from > > food binders by gastric secretions. Nonheme iron absorption is reduced > > by other food items (eg, vegetable fiber phytates and polyphenols; tea > > tannates, including phosphoproteins; bran) and certain antibiotics > > (eg, tetracycline). Ascorbic acid is the only common food element > > known to increase nonheme iron absorption." > > > They didn't mention vitamin C also causes heme iron absorption to > > rise. > > Sooo .. your glass of OJ (hi Gene) in the morning WITH your bacon / > > heme iron .. is gonna give you a jolt of iron which should last you > > for a week .. > > > Who loves ya. > > Tom > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > On Jun 30, 8:14 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > Guideline for the diagnosis, investigation and management of > > > polycythaemia/erythrocytosis. << > > > > "Advise reduction or elimination of factors which may contribute to > > > apparent erythrocytosis" > > > > This is where we lose .. 'them' .. > > > > They fail to adhere to this .. STANDARD OF CARE .. > > > > Some tell us not to go near .. meat .. when we take antibiotics > > > because OF .. ? .. iron .. > > > > Iron is KNOWN to increase red blood cell production. > > > > THAT is why they inject iron INTO .. you. > > > > Isn't .. it .. ? > > > > Well .. isn't it .. ? > > > > They don't tell you not to go near high iron foods .. do they .. > > > > Now .. WHY .. is that .. ? > > > > WHY wouldn't they tell us that "INCREASED IRON CAUSES INCREASED RED > > > BLOOD CELL PRODUCTION" .. > > > > They don't know .. that .. ? > > > > They are chickensht sonsabtches .. ? > > > > Heh .. heh .. > > > > Who loves ya. > > > Tom > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > On Jun 30, 7:50 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > thrombosis << > > > > >http://www.guideline.gov/summary/summary.aspx?doc_id=11995 > > > > > Brief Summary > > > > GUIDELINE TITLE > > > > Guideline for the diagnosis, investigation and management of > > > > polycythaemia/erythrocytosis. > > > > > Who loves ya. > > > > Tom > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > On Jun 30, 7:17 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > > thrombosis << > > > > > >http://tinyurl.com/64dl79 > > > > > > Treatment: > > > > > The objective of treatment is to reduce the high blood viscosity > > > > > (thickness of the blood) due to the increased red blood cell mass and > > > > > to prevent hemorrhage and thrombosis. > > > > > > Phlebotomy is one method used to reduce the high blood viscosity. In > > > > > phlebotomy, 1 unit (pint) of blood is removed weekly until the > > > > > hematocrit is less than 45, then phlebotomy is continued as necessary. > > > > > > Occasionally, chemotherapy may be given to suppress the bone marrow. > > > > > > The use of anti-platelet therapy (such as aspirin) is controversial > > > > > because it may cause gastric bleeding. > > > > > > Allopurinol is given for hyperuricemia (gout). > > > > > > Who loves ya. > > > > > Tom > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > > On Jun 30, 6:56 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > > > thrombosis << > > > > > > >http://qjmed.oxfordjournals.org/cgi/content/full/93/8/497 > > > > > > > Q J Med 2000; 93: 497-499 > > > > > > © 2000 Association of Physicians > > > > > > > ---------------------------------------------------------------------------ÂÂÂÂÂÂ----- > > > > > > > Editorial > > > > > > > Warfarin for multiple sclerosis? > > > > > > > "Today, almost 20 years later, there are enough data to consider > > > > > > antiphospholipid syndrome (APS), or Hughes' syndrome, as a major > > > > > > differential in the diagnosis of definite or probable MS according to > > > > > > Poser's criteria. > > > > > > > Arterial thrombosis is a major feature of Hughes' syndrome, central > > > > > > nervous system vessels being among the most frequently affected" > > > > > > > Who loves ya. > > > > > > Tom > > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > > > On Jun 30, 6:48 am, ironjustice <ironjust...(a)cashette.com> wrote: > > > > > > > thrombosis << > > > > > > > > "Phlebotomy to reduce the red cell mass is of prime importance" > > > > > > > >  http://www.medscape.com/viewarticle/468404_2 > > > > > > > > Who loves ya. > > > > > > > Tom > > > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > > > Man Is A Herbivore!http://tinyurl.com/4rq595 > > > > > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > > > > > > > The thread is .. thrombosis .. > > > > > > > > > Thrombosis ..http://en.wikipedia.org/wiki/Thrombosis > > > > > > > > > Read what thrombosis .. is .. > > > > > > > > > BE .. thrombosis .. > > > > > > > > > Say **something** .. about .. **thrombosis** .. > > > > > > > > > Or .. ? .. stay off **my** thread .. > > > > > > > > > Too hard for you to understand .. ? > > > > > > > > > Heh .. heh .. > > > > > > > > > Must make me .. dangerous .. > > > > > > > > > Who loves ya. > > > > > > > > Tom > > > > > > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > > > > > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > > > > > > > >  DEAD PEOPLE WALKING > > > > > > > >  http://tinyurl.com/zk9fk > > > > > > > > > > ROFL!!!  Tommy, mr rustbucket spammer troll, you have no clue what so > > > > > > > > > ever of what I or anyone else knows. > > > > > > > > > > You KNOW that flooding multiple news groups with the same posts over and > > > > > > > > > over and over and over again is against most all ISP's terms of service. > > > > > > > > > You still do it whether it has anything to do with the group or not! > > > > > > > > > YOU are the stupid one, but then you already know that and so does > > > > > > > > > everyone else! > > > > > > > > > > Is it really necessary to keep posting the same thing over and over and > > > > > > > > > over again? Of course not, but since you are a dangerous spammer troll > > > > > > > > > who practices medicine without a license, advertises commercial sites, > > > > > > > > > and practices dangerous breaches of terms of service, you obviously have > > > > > > > > > no regard or concern for any human life. > > > > > > > > > > When proven wrong, you resort to name calling and foul > > > > > > > > > language---further proof of who you are and what you are!  Sad, so very > > > > > > > > > sad. > > > > > > > > > . > > > > > > > > > . > > > > > > > > > . > > > > > > > > > . > > > > > > > > > .- Hide quoted text - > > > > > > > > > - Show quoted text -- Hide quoted text - > > > > > > > > - Show quoted text -- Hide quoted text - > > > > > > > - Show quoted text -- Hide quoted text - > > > > > > - Show quoted text -- Hide quoted text - > > > > > - Show quoted text -- Hide quoted text - > > > > - Show quoted text -- Hide quoted text - > > ... > > read more »- Hide quoted text - > > - Show quoted text - |