Phlebotomy Improves Hepatitis C
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From: ironjustice on 20 Apr 2008 08:11 On Apr 18, 10:36 am, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: <<snip>> None of these patients developed hepatocellular carcinoma (HCC). <<snip>> http://cancerres.aacrjournals.org/cgi/content/abstract/61/24/8697 Clinical Investigations Normalization of Elevated Hepatic 8-Hydroxy-2'-Deoxyguanosine Levels in Chronic Hepatitis C Patients by Phlebotomy and Low Iron Diet1 Junji Kato, Masayoshi Kobune, Tokiko Nakamura, Ganji Kuroiwa, Kohichi Takada, Rishu Takimoto, Yasuhiro Sato, Koshi Fujikawa, Minoru Takahashi, Tetsuji Takayama, Tatsuru Ikeda and Yoshiro Niitsu2 Fourth Department of Internal Medicine [J. K., T. N., G. K., K. T., R. T., Y. S., K. F., M. T., T. T., Y. N.] and Department of Molecular Medicine [M. K.], Sapporo Medical University School of Medicine, and Department of Clinical Pathology, Sapporo Medical University Hospital [T. I.], Sapporo 060-8543, Japan Accumulation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in DNA, which may result from the continuous reactive oxygen species (ROS) generation associated with chronic inflammation, has been reported in various human preneoplastic lesions and in cancerous tissues. However, no direct causative relationship between the 8-OHdG formation and carcinogenesis has been thus far demonstrated in humans. Directly proving the causality requires showing that depletion of 8-OHdG levels in tissue by interfering with ROS generation results in a reduction in cancer. Chronic hepatitis C virus (HCV) infection is associated with a high risk of hepatocellular carcinoma (HCC). Several studies on patients with chronic HCV have shown that hepatic iron overload is attributable to liver injury and that iron depletion improved serum aminotransferase levels. Excess iron is known to generate ROS within cells, which causes mutagenic lesions, such as 8-OHdG. In this study, therefore, we have evaluated whether therapeutic iron reduction (phlebotomy and low iron diet) with a long-term follow-up (6 years) would decrease the hepatic 8-OHdG levels and the risk of HCC development in patients with chronic HCV. Patients (34) enrolled were those who had undergone standard IFN therapy but had no sustained response. Quantitative immunohistochemistry using the KS-400 image analyzing system and electrochemical detection was used for 8-OHdG detection. With this treatment, elevated hepatic 8-OHdG levels in patients with chronic hepatitis C (8.3 ± 4.6/105 dG) significantly decreased to almost normal levels (2.2 ± 0.9/105 dG; P < 0.001) with concomitant improvement of hepatitis severity, including fibrosis, whereas HCV titers were unaffected. None of these patients developed HCC. Thus, long-term iron reduction therapy in patients with chronic hepatitis C may potentially lower the risk of progression to HCC. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Bloodletting in hepatitis .. > Whoda .. thunk. > > Dig Dis Sci. 2008 Mar;53(3):815-22. Epub 2007 Sep 12. > Phlebotomy improves therapeutic response to interferon in patients > with chronic hepatitis C: a meta-analysis of six prospective > randomized controlled trials. > Desai TK, Jamil LH, Balasubramaniam M, Koff R, Bonkovsky HL. > William Beaumont Hospital, Royal Oak, MI, USA. tusarde...(a)aol.com > > Prospective randomized controlled trials (RCTs) comparing phlebotomy > and interferon (IFN) treatment to IFN alone in > patients with chronic hepatitis C (CHC) have suggested a > benefit for the phlebotomy group. > However, statistical significance was achieved in only one of these > trials. > We performed a meta-analysis of RCTs comparing phlebotomy and IFN to > IFN alone for the treatment of CHC. > The MEDLINE database and Cochrane registry of controlled trials were > searched using the key words "phlebotomy" and "treatment of hepatitis > C." > Reference lists of review articles discussing the interaction between > iron and CHC, and prospective RCTs comparing phlebotomy plus IFN > therapy to IFN alone were searched to identify additional RCTs that > compared phlebotomy > plus IFN to IFN alone. > Peto odds ratios with their 95% confidence intervals and Forrest plots > were generated for each variable to assess the relationships among the > studies that had provided that information. > Statistical analysis was performed using Comprehensive > META-Analysis version 2.0. > Six prospective RCTs were identified: all used sustained viral > response (SVR) as an endpoint. > The three largest RCTs excluded patients with cirrhosis. > Two RCTs specifically included only patients with either high ferritin > or high hepatic iron content. > IFN treatment regimes varied. > Length of treatment varied between 6 and 12 months. > The phlebotomy plus IFN group and the IFN group did not > differ with respect to the percentage of patients with cirrhosis or > genotype 1. > SVR was attained in 50/182 (27%) patients in the phlebotomy plus IFN > group, compared to 22/185 (12%) patients in the > IFN group. > Peto odds ratio for SVR in phlebotomy plus IFN group was > 2.7; 95% CI 1.6-4.5, P < 0.0001. > All five RCTs published in manuscript form showed a trend towards a > benefit from the phlebotomy plus IFN in attaining SVR, and the results > of the meta-analysis were not dependent on any single RCT, since > excluding any single RCT did not change the > results. > Phlebotomy improves the SVR in response to IFN treatment in > patients with CHC. > Confirmation of this will require RCT with detailed pre-treatment iron > studies and appropriately powered to demonstrate a > statistically significant benefit. > > PMID: 17846887 [PubMed - in process] > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
From: ironjustice on 20 Apr 2008 08:14 On Apr 18, 10:36 am, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: Bloodletting in hepatitis << <<snip>> direct hepatocarcinogenic effect of free iron is mediated by the generation of oxygen reactive species and oxidative damage that are mutagenic and carcinogenic <<snip>> 1: Toxicology. 2005 Dec 5; [Epub ahead of print] Links Hepatocellular carcinoma caused by iron overload: A possible mechanism of direct hepatocarcinogenicity. Asare GA, Mossanda KS, Kew MC, Paterson AC, Kahler-Venter CP, Siziba K. MRC/University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa. BACKGROUND/AIMS: Excess hepatic iron may be both directly and indirectly carcinogenic. The aim of this study was to determine if generation of reactive oxygen species and the resulting oxidative damage induced by free hepatic iron is directly hepatocarcinogenic. METHODS: Sixty male Wistar albino rats were iron-loaded by ferrocene supplementation of their diet. Biochemical parameters of oxidative damage and lipid peroxidation, DNA unwinding and strand breaks, and the Ames Mutagenesis Test were measured at 4 monthly intervals and correlated with the degree of hepatic iron overload, the presence of iron-free preneoplastic foci in the liver, and the development of hepatocellular carcinoma in comparison with 60 control rats. RESULTS: Levels of lipid hydroperoxides, malonaldehyde, 8-isoprostane and 8-hydroxy-2'-deoxyguanosine increased, reaching peak concentrations at 20-24 months, and correlating with an increase in the rate of DNA unwinding, strand breaks, and positive Ames Tests. Iron-free neoplastic foci became evident at 16 months and thereafter increased in number. Preneoplastic foci were present in five of eight rats remaining at 32 months and HCC had developed in one of the five. CONCLUSIONS: Our findings are compatible with the hypothesis that the direct hepatocarcinogenic effect of free iron is mediated by the generation of oxygen reactive species and oxidative damage that are mutagenic and carcinogenic. PMID: 16337327 [PubMed - as supplied by publisher] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Bloodletting in hepatitis .. > Whoda .. thunk. > > Dig Dis Sci. 2008 Mar;53(3):815-22. Epub 2007 Sep 12. > Phlebotomy improves therapeutic response to interferon in patients > with chronic hepatitis C: a meta-analysis of six prospective > randomized controlled trials. > Desai TK, Jamil LH, Balasubramaniam M, Koff R, Bonkovsky HL. > William Beaumont Hospital, Royal Oak, MI, USA. tusarde...(a)aol.com > > Prospective randomized controlled trials (RCTs) comparing phlebotomy > and interferon (IFN) treatment to IFN alone in > patients with chronic hepatitis C (CHC) have suggested a > benefit for the phlebotomy group. > However, statistical significance was achieved in only one of these > trials. > We performed a meta-analysis of RCTs comparing phlebotomy and IFN to > IFN alone for the treatment of CHC. > The MEDLINE database and Cochrane registry of controlled trials were > searched using the key words "phlebotomy" and "treatment of hepatitis > C." > Reference lists of review articles discussing the interaction between > iron and CHC, and prospective RCTs comparing phlebotomy plus IFN > therapy to IFN alone were searched to identify additional RCTs that > compared phlebotomy > plus IFN to IFN alone. > Peto odds ratios with their 95% confidence intervals and Forrest plots > were generated for each variable to assess the relationships among the > studies that had provided that information. > Statistical analysis was performed using Comprehensive > META-Analysis version 2.0. > Six prospective RCTs were identified: all used sustained viral > response (SVR) as an endpoint. > The three largest RCTs excluded patients with cirrhosis. > Two RCTs specifically included only patients with either high ferritin > or high hepatic iron content. > IFN treatment regimes varied. > Length of treatment varied between 6 and 12 months. > The phlebotomy plus IFN group and the IFN group did not > differ with respect to the percentage of patients with cirrhosis or > genotype 1. > SVR was attained in 50/182 (27%) patients in the phlebotomy plus IFN > group, compared to 22/185 (12%) patients in the > IFN group. > Peto odds ratio for SVR in phlebotomy plus IFN group was > 2.7; 95% CI 1.6-4.5, P < 0.0001. > All five RCTs published in manuscript form showed a trend towards a > benefit from the phlebotomy plus IFN in attaining SVR, and the results > of the meta-analysis were not dependent on any single RCT, since > excluding any single RCT did not change the > results. > Phlebotomy improves the SVR in response to IFN treatment in > patients with CHC. > Confirmation of this will require RCT with detailed pre-treatment iron > studies and appropriately powered to demonstrate a > statistically significant benefit. > > PMID: 17846887 [PubMed - in process] > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
From: eileen on 21 Apr 2008 18:28 On Apr 19, 9:45 pm, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: > > Listen up .. > > >> > So .. take your singing anywhere BUT **my** thread .. because .. ? .. > it is a thread about the success of bloodletting / phlebotomy in > hepatitis .. something YOU know .. admittingly .. fkall about .. > > Sooo .. take your opinions of ME .. my work .. to yourself .. because > again .. being that you've only been around for a couple of years .. > means .. you KNOW fkall about me .. and I have learned quite abit > about YOU .. in no time at'all .. > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > Tom, Could you please present us with your credentials and tell us what actually is your work. This is an honest question, are you a member of the AMA or any of the Medical Sciences? Are you paid to be in research? And if, so please direct me to your professional board. In no way am I being hostile, I am just trying to understand what your position is. eileen
From: ironjustice on 21 Apr 2008 19:44 On Apr 21, 3:28 pm, eileen <samiamtwo...(a)yahoo.com> wrote: (drivel snipped) In no way am I being hostile << "drivel" "In no way am I being hostile" .. You must really think I am about as stupid as yourself .. driv·el 1. saliva flowing from the mouth, or mucus from the nose; slaver. 2. childish, silly, or meaningless talk or thinking; nonsense; twaddle. verb (used without object) 3. to let saliva flow from the mouth or mucus from the nose; slaver. 4. to talk childishly or idiotically. 5. Archaic. to issue like spittle. verb (used with object) 6. to utter childishly or idiotically. 7. to waste foolishly. hostile 1 a: of or relating to an enemy <hostile fire> b: marked by malevolence <a hostile act> c: openly opposed or resisting <a hostile critic> <hostile to new ideas> d (1): not hospitable <plants growing in a hostile environment> (2): having an intimidating, antagonistic, or offensive nature <a hostile workplace> 2 a: of or relating to the opposing party in a legal controversy <a hostile witness> b: adverse to the interests of a property owner or corporation management <a hostile takeover> On Apr 21, 3:28 pm, eileen <samiamtwo...(a)yahoo.com> wrote:please direct me to your professional board << I suppose you might direct it to .. Education and Training , Mount Everest. Make sure you use the .. acronym. Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk please direct me to your professional board. In no way am I being hostile, I am just trying to understand what your position is. << > On Apr 19, 9:45 pm, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: > > > > > > > Listen up .. > > > So .. take your singing anywhere BUT **my** thread .. because .. ? .. > > it is a thread about the success of bloodletting /phlebotomyin > >hepatitis.. something YOU know .. admittingly .. fkall about .. > > > Sooo .. take your opinions of ME .. my work .. to yourself .. because > > again .. being that you've only been around for a couple of years .. > > means .. you KNOW fkall about me .. and I have learned quite abit > > about YOU .. in no time at'all .. > > > Who loves ya. > > Tom > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > Tom, > Could you please present us with your credentials and tell us what > actually is your work. > This is an honest question, are you a member of the AMA or any of the > Medical Sciences? > Are you paid to be in research? And if, so please direct me to your > professional board. > In no way am I being hostile, I am just trying to understand what your > position is. > eileen- Hide quoted text - > > - Show quoted text -
From: eileen on 21 Apr 2008 20:02
On Apr 21, 7:44 pm, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: > On Apr 21, 3:28 pm, eileen <samiamtwo...(a)yahoo.com> wrote: > (drivel snipped) In no way am I being hostile << > > "drivel" > "In no way am I being hostile" .. > > You must really think I am about as stupid as yourself .. > > driv·el > 1. saliva flowing from the mouth, or mucus from the nose; slaver. > 2. childish, silly, or meaningless talk or thinking; nonsense; > twaddle. > verb (used without object) 3. to let saliva flow from the mouth or > mucus from the nose; slaver. > 4. to talk childishly or idiotically. > 5. Archaic. to issue like spittle. > verb (used with object) 6. to utter childishly or idiotically. > 7. to waste foolishly. > > hostile > > 1 a: of or relating to an enemy <hostile fire> b: marked by > malevolence <a hostile act> c: openly opposed or resisting <a hostile > critic> <hostile to new ideas> d (1): not hospitable <plants growing > in a hostile environment> (2): having an intimidating, antagonistic, > or offensive nature <a hostile workplace> > 2 a: of or relating to the opposing party in a legal controversy <a > hostile witness> b: adverse to the interests of a property owner or > corporation management <a hostile takeover> > > On Apr 21, 3:28 pm, eileen <samiamtwo...(a)yahoo.com> wrote:please > direct me to your professional board << > > I suppose you might direct it to .. Education and Training , Mount > Everest. > > Make sure you use the .. acronym. > > Who loves ya. > Tom > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > please direct me to your professional board. In no way am I being > hostile, I am just trying to understand what your position is. << > > > > > On Apr 19, 9:45 pm, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: > > > > Listen up .. > > > > So .. take your singing anywhere BUT **my** thread .. because .. ? ... > > > it is a thread about the success of bloodletting /phlebotomyin > > >hepatitis.. something YOU know .. admittingly .. fkall about .. > > > > Sooo .. take your opinions of ME .. my work .. to yourself .. because > > > again .. being that you've only been around for a couple of years .. > > > means .. you KNOW fkall about me .. and I have learned quite abit > > > about YOU .. in no time at'all .. > > > > Who loves ya. > > > Tom > > > > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh > > > > Man Is A Herbivore!http://tinyurl.com/a3cc3 > > > > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk > > > Tom, > > Could you please present us with your credentials and tell us what > > actually is your work. > > This is an honest question, are you a member of the AMA or any of the > > Medical Sciences? > > Are you paid to be in research? And if, so please direct me to your > > professional board. > > In no way am I being hostile, I am just trying to understand what your > > position is. > > eileen- Hide quoted text - > > > - Show quoted text -- Hide quoted text - > > - Show quoted text - Just as I thought, poor little boy Just a little FT......................................... |