Pegylated interferon and ribavirin
in [Hepatitis]
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From: ironjustice on 23 May 2007 21:20 Now who to .. believe .. the researchers who find .. "The treatment of hepatitis C with the combination of pegylated interferon and ribavirin is still both problematic and costly, has suboptimal efficacy, serious side effects and a high level of intolerance, and is contraindicated in many patients. " or those .. who say .. "cure" .. ? Hepatol Res. 2007 May 22; [Epub ahead of print] Immunopathogenesis of hepatitis C virus infection and hepatic fibrosis: New insights into antifibrotic therapy in chronic hepatitis C.Teixeira R, Marcos LA, Friedman SL. School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Fibrosis and cirrhosis represent the consequences of a sustained wound- healing response to chronic liver injury of any cause. Chronic hepatitis C virus (HCV) has emerged as a leading cause of cirrhosis in the USA and throughout the world. HCV may induce fibrogenesis directly by hepatic stellate cell activation or indirectly by promoting oxidative stress and apoptosis of infected cells. The ultimate result of chronic HCV injury is the accumulation of extracellular matrix with high density type I collagen within the subendothelial space of Disse, culminating in cirrhosis with hepatocellular dysfunction. The treatment of hepatitis C with the combination of pegylated interferon and ribavirin is still both problematic and costly, has suboptimal efficacy, serious side effects and a high level of intolerance, and is contraindicated in many patients. Hence, new approaches have assumed greater importance, for which there is an urgent need. The sustained progress in understanding the pathophysiology of hepatic fibrosis in the past two decades has increased the possibility of developing drugs specifically targeting the fibrogenic process. Future efforts should identify genetic markers associated with fibrosis risk in order to tailor the treatment of HCV infection based on genetically regulated pathways of injury and/or fibrosis. Such advances will expand the arsenal to overcome liver fibrosis, particularly in patients with hepatic diseases who have limited treatment options, such as those patients with chronic hepatitis C who have a high risk of fibrosis progression and recurrent HCV disease after liver transplantation. PMID: 17517074 [PubMed - as supplied by publisher] --------------------------------------------------------------- Hepatitis C drugs provide 'cure' The virus is carried in blood cells People infected with hepatitis C can be cured with existing treatments, researchers have discovered. Around 99% of patients successfully treated with pegylated interferon and ribavirin had no detectable virus for up to seven years. The treatments were known to work initially but it had been unclear whether the virus would come back. Experts said it was good news for patients but that some still suffer from painful symptoms. Over the past decade the number of people in the UK diagnosed with hepatitis C has increased because of higher rates of testing. This data looks incredibly promising and it's extremely good news for patients as they are always concerned that the virus would come back Charles Gore, Hepatitis C Trust But many people are still unaware they are carrying the infection. Hepatitis C, which is contracted through infected blood, can cause cirrhosis, liver failure or cancer. Early treatment is usually effective. Long-term cure Professor Mitchell Shiffman, chief of hepatology at the Virginia Commonwealth University Medical School, and colleagues carried out a long-term study in 1,000 patients to find out whether the virus would come back. Participants were given a course of injections of pegylated interferon alone or in combination with ribavirin. In those for whom treatment was successful (no detectable virus after six months) only eight patients tested positive for the virus in the following seven years. The researchers pointed out it had not yet been determined if those patients had suffered a relapse or been reinfected. Professor Shiffman said: "We are encouraged by this data because it is rare in the treatment of life-threatening viral diseases that we can tell patients they may be cured. "In hepatitis C today, we are able to help some patients achieve an outcome that effectively enables them to put their disease behind them." It is believed that around 250,000 people in the UK have signs of hepatitis C infection, although some of these will clear it naturally and not become chronically infected. However, the number could actually be as high as half a million and it is estimated that nine out of ten people do not know they are infected. It can take years or even decades for symptoms to appear but a recent Department of Health campaign has been encouraging those at risk to get tested. Anyone who ever shared equipment for injecting drugs - even if it was a long time ago, and even if they only did it once or twice - they could be at risk from hepatitis C. Others could have become infected through a blood transfusion, if they received one before screening was introduced in 1991 - or through sharing banknotes or straws to snort cocaine. Charles Gore, chief executive of the Hepatitis C trust said the results would be reassuring for patients who had to undergo six months to a year of weekly injections and daily tablets. "This data looks incredibly promising and it's extremely good news for patients as they are always concerned that the virus would come back." "The only thing we would add is that we're talking about a cure for liver disease, which is the thing that kills you, but not everyone feels fantastic at the end of treatment - some people have lingering symptoms such as aches in their joints and feeling tired." Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: greyhackles on 23 May 2007 21:30 On 23 May 2007 18:20:09 -0700, ironjustice <ironjustice(a)cashette.com> publicly pouted: >Now who to .. believe .. the researchers who find .. "The treatment of >hepatitis C with the combination of pegylated interferon and ribavirin >is still both problematic and costly, has suboptimal efficacy, serious >side effects and a high level of intolerance, and is contraindicated >in many patients. " or those .. who say .. "cure" .. ? <yawn> The difficulties and uncertainties with the current standard of care are hardly news to these groups. You're wasting our time and yours... /greyhackles
From: Paul on 24 May 2007 01:08 On Wed, 23 May 2007 21:30:15 -0400, greyhackles <greyhackles(a)NOSPAMyahoo.com>, in message ID <ceq9539nk0ehhq06tvn1jg8vf204q4ndj7(a)4ax.com>, in the newsgroup alt.support.hepatitis-c wrote: ><yawn> > >The difficulties and uncertainties with the current standard of care are >hardly news to these groups. > >You're wasting our time and yours... > >/greyhackles Maybe it's been raining. Our ferric friend seems to be getting a bit rusty.
From: ironjustice on 24 May 2007 15:37 >>On May 23, 6:30 pm, greyhackles <greyhack...(a)NOSPAMyahoo.com> wrote: You're wasting our time and yours... /greyhackles<< Actually .. the second article is pretty .. new .. It was only placed yesterday on the internet .. Why don't you find out how many of those 1000 were cured .. as opposed to the 75% - 85% offered by .. iron reduction .. ? Because .. YOU .. don't really .. give a fk .. there .. grey .. THAT is .. **why** .. YOU are a two bit fkg .. troll .. with nothing but .. sht .. to say .. Soooo .. since you say .. sht .. contribute sht .. one can conclude you most likely are .. full of sht .. And that .. on medical lists .. is a .. bad .. thing .. So .. read my lips .. Fk .. off .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: Brindal on 24 May 2007 16:10 On May 24, 2:37 pm, "ironjust...(a)aol.com" <ironjust...(a)aol.com> wrote: > YOU are a two bit fkg .. troll .. with nothing but .. sht .. to say .. > > Soooo .. since you say .. sht .. contribute sht .. one can conclude > you most likely are .. full of sht .. Now, that is one of the best desciptions of Ironjustice I have read yet. > So .. read my lips .. > > Fk .. off .. Take your own advice. Brindal
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