Oxidative Stress and Food [Fibromyalgia]

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From: ironjustice on 25 Jul 2008 08:39

"Unprecedented radioprotection by a dietary supplement comprised of
ingredients available to the general public"

Elevated DNA damage in a mouse model of oxidative stress: impacts of
ionizing radiation and a protective dietary supplement. Lemon JA,
Rollo CD, Boreham DR
Mutagenesis 2008 Jul 21.

Transgenic growth hormone (Tg) mice express elevated free radical
processes and a progeroid syndrome of accelerated ageing.
We examined bone marrow cells of Tg mice and their normal (Nr)
siblings for three markers of DNA damage and assessed the impact of
free radical stress using ionizing radiation.
We also evaluated the radiation protection afforded by a dietary
supplement that we previously demonstrated to extend longevity and
reduce cognitive ageing of Nr and Tg mice.
Spectral karyotyping revealed few spontaneous chromosomal aberrations
in Nr or Tg.
Tg mice, however, had significantly greater constitutive levels of
both gammaH2AX and 8-hydroxy-deoxyguanosine (8-OHdG) compared to Nr.
When exposed to a 2-Gy whole-body dose of ionizing radiation, both Nr
and Tg mice showed significant increases in DNA damage. Compared to
Nr
mice, irradiated Tg mice had dramatically higher levels of gammaH2AX
foci and double the levels of chromosomal aberrations.
In unirradiated mice, the dietary supplement significantly reduced
constitutive gammaH2AX and 8-OHdG in both Nr and Tg mice (normalizing
both gammaH2AX and 8-OHdG in Tg), with little difference in gammaH2AX
and 8-OHdG over constitutive levels. Induced chromosomal aberrations
were also reduced, and in Nr mice, virtually absent.
Remarkably, supplemented mice expressed 6-fold lower levels of
radiation-induced chromosomal aberrations compared to unsupplemented
Nr or Tg mice.
Based on our data, the dietary supplement appeared to scavenge free
radicals before they could cause damage.
This study validates Tg mice as an exemplary model of oxidative
stress
and radiation hypersensitivity and documents unprecedented
radioprotection by a dietary supplement comprised of ingredients
available to the general public.

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Mutagenesis [Mutagenesis]

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From: Chuck on 25 Jul 2008 17:05

On Jul 24, 4:01 pm, "Paul T. Holland" <pholl...(a)bellatlantic.net>
wrote:

> Acetyl-L-carnitine/ acetyl-L-carnitine hydrochloride/ acetyl-L-carnitine
> arginate dihydrochloride
> R-dihydro-lipoic acid
> Fish oil eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)
> Coenzyme Q10
> DHEA
> Garlic
> Ginkgo biloba
> Ginseng
> L-glutathione with cysteine and vitamin C
> Melatonin
> Gamma E mixed tocopherols/sesame lignans
> Low-dose aspirin
> Digestive enzymes [??? not narrow enough ]
> Resveratrol

That's actually an excellent line-up of antioxidant/inflammatory
agents. I would add biotin with the R-lipoic acid for optimal
carboxylase enzyme action. I don't do melatonin nor DHEA because I
just outright don't respond well to them.(feel well). Also, throw in
some tocotrienols with the tocopherols and add curcumin to the list.
Take cysteine as N-acetyl-cysteine.
CB

From: ironjustice on 25 Jul 2008 17:16

From: ferrous on 25 Jul 2008 17:51

I always thought the key to this thread is simple, consider:

"impacts of ionizing radiation"

avoid radiation in excess. This might be of interest if we were poor lab
rats being zapped with excessive radiation.

Do the "suppliments" in question include animal sources?

Jesus ate a mediterranean diet.

From: ironjustice on 29 Jul 2008 16:26

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