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From: ironjustice on 7 Aug 2008 14:39
"Oxidative stress may offer a common explanation"

Prostaglandins Leukot Essent Fatty Acids. 2004 Sep;71(3):181-3.
In vivo magnetic resonance spectroscopy in chronic fatigue syndrome.


Chaudhuri A, Behan PO.


Division of Clinical Neurosciences, Institute of Neurological
Sciences,
Southern General Hospital, University of Glasgow, 1345 Govan Road,
Glasgow G51
4TF, UK.


The pathogenic mechanisms of chronic fatigue syndrome (CFS) are not
clearly known.
Fatigue, poor short-term memory and muscle pain are the most disabling
symptoms in CFS. Research data on magnetic resonance spectroscopy
(MRS) of muscles and brain in CFS patients suggest a cellular
metabolic abnormality in
some cases. (31)P MRS of skeletal muscles in a subset of patients
indicate early intracellular acidosis in the exercising muscles.
(1)H MRS of the regional brain areas in CFS have shown increased peaks
of choline derived from the cell membrane phospholipids. Cell membrane
oxidative stress may offer a common explanation for the observed MRS
changes in the muscles and brain of CFS
patients and this may have important therapeutic implications.
As a research tool, MRS may be used as an objective outcome measure in
the intervention studies.
In addition, regional brain (1)H MRS has the potential for wider use
to substantiate a clinical diagnosis of CFS from other disorders of
unexplained chronic fatigue.


PMID: 15253888 [PubMed - in process]

-----------------------

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Tom


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From: Chuck on 7 Aug 2008 15:26
On Aug 7, 2:39�pm, ironjustice <teamtan...(a)hotmail.com> wrote:
> "Oxidative stress may offer a common explanation"

Gee, thanks Tom. Now what should people do to use this info to help
themselves.?

CB

From: High Miles on 7 Aug 2008 16:59
Chuck wrote:
> On Aug 7, 2:39�pm, ironjustice <teamtan...(a)hotmail.com> wrote:
>> "Oxidative stress may offer a common explanation"
>
> Gee, thanks Tom. Now what should people do to use this info to help
> themselves.?
>
> CB
>
Stop reading this idiots posts ?
From: jay on 7 Aug 2008 17:20
> "Oxidative stress may offer a common explanation"
> In vivo magnetic resonance spectroscopy in chronic fatigue syndrome.
> The pathogenic mechanisms of CFS are not clearly known.
> Cell membrane oxidative stress may offer a common explanation
> PMID: 15253888 [PubMed - in process]

In some cases, Persistent Organic Pollutants (POPs) can cause CFS via
cellular ROS. TCDD, a potent dioxin, has a high affinity for lipids.
The nervous system is high in lipids. In addition, TCDD has a half
life of 10 years in the human body. The most common source for most
people was/is via dietary meat/fish/poultry/egg/dairy fats.

Induction of Oxidative Stress Responses by Dioxin and other Ligands of
the Aryl Hydrocarbon Receptor.
TCDD and other polyhalogenated aromatic hydrocarbon ligands of the
aryl hydrocarbon receptor (AHR) have been classically considered as
non-genotoxic compounds because they fail to be directly mutagenic in
either bacteria or most in vitro assay systems. They do so in spite of
having repeatedly been linked to oxidative stress and to mutagenic and
carcinogenic outcomes. Oxidative stress, on the other hand, has been
used as a marker for the toxicity of dioxin and its congeners. We have
focused this review on the connection between oxidative stress
induction and the toxic effects of fetal and adult dioxin exposure,
with emphasis on the large species difference in sensitivity to this
agent. We examine the roles that the dioxin-inducible cytochromes
P450s play in the cellular and toxicological consequences of dioxin
exposure with emphasis on oxidative stress involvement. Many
components of the health consequences resulting from dioxin exposure
may be attributable to epigenetic mechanisms arising from prolonged
reactive oxygen generation. PMID: 18648615


Relationship between clinical features and blood levels of
pentachlorodibenzofuran in patients with Yusho.
Yusho is a form of food poisoning that occurred in 1968, as a result
of consuming rice bran oil contaminated with polychlorinated biphenyls
(PCBs) and various dioxins such as polychlorinated dibenzofurans
(PCDFs). The victims of Yusho suffered from various dermatological,
ophthalmological, and mucosal symptoms in addition to general FATIGUE,
weight loss, anorexia, headache, paresthesia of the extremities,
abdominal pain, cough and sputa, dysmenorrhea, and growth retardation
in infants and children ... PMID: 17366567


External Qi therapy to treat symptoms of Agent Orange Sequelae in
Korean combat veterans of the Vietnam War.
We investigated the efficacy of Qi therapy as a non-pharmacological
treatment for various symptoms presented by Korean combat veterans of
the Vietnam War with Agent Orange Sequelae. Nine subjects volunteered
to receive 30 minutes of Qi therapy, twice per day for 7 days. There
was marked improvement in 89% of the patients with impaired physical
activity, 86% of those with psychological disorder, 78% of those with
heavy drug use, and 67% of those with FATIGUE, indigestion and high
blood glucose levels. This data suggests that Qi therapy combined with
conventional treatment has positive effects in reducing and managing
the pain, psychosomatic disorders, and substance abuse in patients
with Agent Orange Sequelae. We cannot completely discount the possible
influence of the placebo effect, and more objective, clinical measures
are needed to study the long-term effects of Qi therapy. PMID:
15344429


Dystonia and tremor following exposure to 2,3,7,8-tetrachlorodibenzo-p-
dioxin.
Forty-seven railroad workers who were exposed to polychlorinated
phenols, including dioxin (TCDD), during 1979 while cleaning up the
chemical spillage following damage to a tank car filled with these
chemicals were followed medically for the subsequent 6 years. Two
committed suicide. The initial neurological complaints included a
sense of FATIGUE and muscle aching, both of which have been reported
in other individuals following dioxin exposure. On detailed
neurological examination in December, 1985, 24 of 45 had dystonic
writer's cramp and/or other action dystonias of the hands. None of the
involved individuals had a family history of dystonia, and all 24
dated the onset of the dystonia to the first 2 to 3 years subsequent
to their toxic exposure. The dystonias varied in severity but were
usually mild. No other types of dystonic involvement were recognized.
Thirty-five of the 45 individuals also manifested postural and
terminal intention tremor which resembled benign essential tremor.
None of the involved individuals had a family history of tremor, and
all 35 of those affected dated the onset of the tremor to some time
subsequent to their toxic exposure. Forty-three of 45 patients had
histories and findings suggestive of peripheral neuropathy. This is
the first report relating any type of dystonia to prior dioxin
exposure and the first report relating action dystonia, such as
dystonic writer's cramp, and postural/terminal intention tremor, to
toxic exposure of any type. PMID: 2849055


Commentary on 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD).
There is deep concern about the long term health effects of exposure
to phenoxy herbicides and the contaminant TCDD; however, there is
considerable scientific and medical uncertainty regarding the health
effects from exposure to these chemicals. There are at least ten
ongoing studies on reproduction, morbidity and mortality as well as
studies of tissue concentrations of TCDD that are attempting to
determine the health effects of these chemicals (see Table 2).
Appropriate efforts should be made to prevent human and environmental
exposure and to decontaminate the environment while awaiting the
results of these investigations. Animal toxicity studies show such
wide variations that extrapolations from a different species to humans
are tenuous. Human studies on exposed workers and nonoccupational
exposures are difficult to interpret because the exposure has not been
quantified and because workers were exposed to mixtures of chemicals.
Chloracne appears to be an important specific clinical marker of TCDD
exposure, however, it can be caused by structurally similar compounds.
Many of the past studies on human health effects of 2,4,5-T and TCDD
are controversial. Since the scientific data are not firm, no specific
statements can be made regarding the long term health effects at this
time. Any individual who has had a significant exposure to TCDD should
see his/her physician and have appropriate consultation. Long term
follow up will be required. Physicians should be instructed regarding
the possible manifestations of TCDD exposure to look for chloracne,
soft tissue masses, muscle pain, FATIGUE, peripheral neuropathy,
tender hepatic enlargement, enlargement, elevated liver enzymes,
elevated lipids, prolonged prothrombin time, hemorrhagic cystitis and
hirsutism. PMID: 4060565
From: ironjustice on 7 Aug 2008 17:51
On Aug 7, 12:26 pm, Chuck <ShorThi...(a)aol.com> wrote:Gee, thanks Tom.
Now what should people do to use this info to help themselves.? <<

Do I look like a fkg doctor .. or a .. nutritionist .. ?

Heh .. heh ..

YOU tell them to take .. antioxidants .. there .. chuck ..

Put a post on this thread .. maybe even change the thread .. title ..

Change it to "how to treat oxidative stress" ..

Then start typing everything you know that will combat .. oxidative ..
stress ..

Shouldn't be hard for a .. nutritionist .. should it .. ?

On second thought .. start a thread of your own ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

> On Aug 7, 2:39 pm, ironjustice <teamtan...(a)hotmail.com> wrote:
>
> > "Oxidative stress may offer a common explanation"
>
> Gee, thanks Tom. Now what should people do to use this info to help
> themselves.?
>
> CB

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