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From: ironjustice on 20 Sep 2008 23:31
Correlation of Lipid Peroxidation and Glutathione Levels with severity
of Systemic Lupus Erythematosus: a Pilot study from Single Center.
Panomvana D, Tewthanom K, Janwityanuchit S, Totemchockchyakarn K
J Pharm Pharm Sci 2008 May-August; 11(3):30-34.

Purpose.
Systemic Lupus Erythematosus (SLE) is a multifactoral chronic
autoimmune disease with unidentified etiology.
Imbalance of oxidative status is one possible cause of active
disease.
Plasma malondialdehyde (MDA) and plasma glutathione (GSH) level have
been used as a determinate of oxidative status.
Limited data has examined these 2 parameters by severity of SLE.
Methods.
We determined whether there was an association between plasma MDA and
plasma GSH level with the severity of SLE.
Forty four SLE patients (2 Men and 42 Women) and twenty healthy
volunteers (3 Men, 17 women) participated in this study.
SLE participants were classified by the severity of disease (mild,
moderate or severe).
The plasma MDA and plasma Glutathione levels were measured.
The correlation of plasma MDA and plasma GSH levels with the severity
of SLE disease were determined.
Results.
Plasma MDA levels with different severity of SLE (mild, moderate, and
severe of SLE patients) were not significantly different from those of
the control group (p=1.0).
Plasma GSH levels were significantly lower in the moderate and severe
SLE groups than the control group (p=0.001).
In addition, a significant correlation between plasma GSH and severity
of SLE was observed.
(Pearson correlation coefficient = -0.428, p<0.001).
The relationship could be described by the equation GSH level (muM) =
(-7.624) SLEDAI score +545.90.
Conclusion.
A significant correlation between plasma GSH and SLE severity exists
that may aid evaluation of the disease severity and usefulness of the
treatment of SLE.

Journal of pharmacy & pharmaceutical sciences : a publication of the
Canadian Society for Pharmaceutical Sciences, Societe canadienne des
sciences pharmaceutiques [J Pharm Pharm Sci]

--------------------------------------------------------------------------------

The Relation Of Malondialdehyde And Superoxide Dismutase To The
Pathogenesis Of Systemic Lupus Erythematosus And Effect Of
Antioxidants On The Disease Activity
Zeinab Tosson, Sahar Al Mokadem, Enayat Attwa, Iman Nofal, Manal
Mohamed El Sayed and Osama A. Gaber#
Egyptian Dermatology Online Journal 2 (2):10, December 2006.

* Departments of Dermatology&Venereology and Biochemistry#
Faculty of Medicine, Zagazig University


Submitted: July, 2006
Accepted for publication: November, 2006.
---------------------------------------------------------------------------­-----


Abstract
Background:


Systemic lupus erythematosus (SLE) is a chronic complex multifactorial
autoimmune disease. Reactive oxygen species (ROS) are claimed to play
a role in this disease.

Objective:

To disclose the effect of oxidants represented by malondialdehyde
(MDA) and the antioxidant activity represented by superoxide dismutase
(SOD) on SLE activity and the possible role of antioxidants in the
treatment of the disease.

Patients and methods:

The level of SOD and MDA were measured in 52 persons; 20 patients with
active SLE and 17 SLE patients in remission as measured by Systemic
Lupus Activity Measure (SLAM), plus 15 control persons of matched age
and sex.
The active group received a course of antioxidants (800 IU of vitamin
E daily and 500 mg of vitamin C twice daily) plus 20 mg of
prednisolone daily.
The activity is remeasured after three months of treatment.

Results:

Serum MDA was significantly elevated in the active group as compared
to the remission group.
Both groups showed higher level of MDA when compared to the control
group.
The level of SOD was higher in control and remission groups than in
the active group.
There was an inverse relation between the level of MDA and SOD in both
the active and remission groups.
There was no significant correlation between MDA and SOD in the
control group.
The SLAM score and MDA level decreased significantly in the active
group after receiving the aforementioned treatment while there was non
significant increase in SOD.

Conclusion:

The oxidative burden - represented by MDA - is involved in the
pathogenesis of SLE, and SOD acts as a protective agent against this
damage.
Antioxidants; as vitamins E and C can be used as adjunctive treatment
for SLE.

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