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From: ironjustice on 1 Aug 2008 09:06
"NPBI could play an important role in oxidative stress"

Oxidative stress, erythrocyte ageing and plasma non-protein-bound iron
in diabetic patients.
Leoncini S, Rossi V, Signorini C, Tanganelli I, Comporti M, Ciccoli L
Free Radic Res 2008 Jul 30.:1-9.

Increased oxidative stress and decreased life span of erythrocytes
(RBCs) are repeatedly reported in diabetes.
In the aim to elucidate the mechanism of the latter, i.e. the events
leading to erythrocyte ageing, this study determined in RBCs from
diabetic patients iron release in a free desferrioxamine-chelatable
form (DCI), methemoglobin (MetHb) formation, binding of autologous IgG
to membrane proteins and in plasma non-protein-bound iron (NPBI), F(2)-
Isoprostanes (F(2)-IsoPs) and advanced oxidation protein products
(AOPP).
DCI and MetHb were higher in diabetic RBCs than in controls and
autologous IgG binding occurred in a much higher percentage of
diabetic patients than controls.
A significant correlation between DCI and IgG binding was found in
diabetic RBCs. Plasma NPBI, esterified F(2)-IsoPs and AOPP were higher
in diabetic patients and a significant correlation was found between
plasma NPBI and intra-erythrocyte DCI. The increased DCI and
autologous IgG binding appear to be important factors in the
accelerated removal of RBCs from the blood stream in diabetes and the
increase in plasma NPBI could play an important role in the increased
oxidative stress.

Free radical research [Free Radic Res]


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