Nocturnal secretion of melatonin in patients with upper digestive tract disorders.
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From: christine.l.ayoub on 30 Nov 2007 14:44 How much do you take and do you take it every night? Thanks, Christine On Nov 27, 2:28 am, trigonometry1...(a)gmail.com wrote: > This is something interesting, I've been taking it on a regular > basis for at least several years. I wonder if it > played a role in my getting better with all the > other stuff I do? > ----------------------------- > > J Physiol Pharmacol. 2006 Nov;57 Suppl 5:41-50. > > Nocturnal secretion of melatonin in patients with upper digestive > tract > disorders. > > KlupiÅska G, WiÅniewska-JarosiÅska M, Harasiuk A, > Chojnacki C, Stec-Michalska K, > BÅ,asiak J, Reiter RJ, Chojnacki J. > > Department of Gastroenterology and Internal Diseases, Medical > University of Lodz, 1 Haller's Square, > 90-647 Lodz, Poland. > gas...(a)achilles.wam.lodz.pl. > > Recently, the results of many experimental investigations have > shown that melatonin possesses gastroprotective properties. > On the other hand its role in pathogenesis of upper digestive tract > diseases in man still remains unclear. The aim of the study was to > investigate nocturnal secretion of melatonin in patients > with functional and organic diseases of the upper part of digestive > tract. The investigations were carried out in 149 persons, aged 21-51 > years, including > healthy subjects (group I, n=30), > and patients with > non-erosive gastroduodenal reflux (NERD, group II, n=24), > with gastroesophageal reflux disease (GERD, group III, n=25), > with functional dyspepsia (FD, according to the Rome III Criteria, > group IV, n=36) and with recurrent duodenal ulcer (DUD, group V, > n=34). Diagnoses were established on the basis of endoscopic imaging > and histological examination, 24-hour pH-metry and laboratory tests. > Melatonin serum concentration was measured > with ELISA method. Blood samples were taken for examination in red- > lighted room at 10 p.m. and on the following day at 2 and 6 a.m. The > highest concentration of melatonin in all examined groups was > determined at 2 a.m. The average melatonin concentration in healthy > subjects was 34,7 +/- 4,8 pg/ml. In patients with GERD > and DUD melatonin concentration was lower than in > healthy subjects - 27,2 +/- 8,5 pg/ml and 25,5 +/- 6,2 pg/ml > respectively (p < 0,05; p < 0,01). > The highest concentration of melatonin was found in patients with NERD > and FD - 43,2 +/- 10,8 pg/ml and > 42,4 +/- 10,1 pg/ml (p < 0,01; p < 0,05). > The findings of this study > support the notion that melatonin exerts beneficial influences on the > upper digestive tract. It is likely that high or relatively correct > secretion of melatonin is sufficient to prevent peptic changes in > esophageal and duodenal > mucosa. > > PMID: 17218759
From: trigonometry1972 on 30 Nov 2007 23:28 On Nov 30, 11:44 am, christine.l.ay...(a)intel.com wrote: > How much do you take and do you take it every night? > > Thanks, > > Christine > > On Nov 27, 2:28 am, trigonometry1...(a)gmail.com wrote: > > > This is something interesting, I've been taking it on a regular > > basis for at least several years. I wonder if it > > played a role in my getting better with all the > > other stuff I do? > > ----------------------------- > > > J Physiol Pharmacol. 2006 Nov;57 Suppl 5:41-50. > > > Nocturnal secretion of melatonin in patients with upper digestive > > tract > > disorders. > > > KlupiÅska G, WiÅniewska-JarosiÅska M, Harasiuk A, > > Chojnacki C, Stec-Michalska K, > > BÅ,asiak J, Reiter RJ, Chojnacki J. > > > Department of Gastroenterology and Internal Diseases, Medical > > University of Lodz, 1 Haller's Square, > > 90-647 Lodz, Poland. > > gas...(a)achilles.wam.lodz.pl. > > > Recently, the results of many experimental investigations have > > shown that melatonin possesses gastroprotective properties. > > On the other hand its role in pathogenesis of upper digestive tract > > diseases in man still remains unclear. The aim of the study was to > > investigate nocturnal secretion of melatonin in patients > > with functional and organic diseases of the upper part of digestive > > tract. The investigations were carried out in 149 persons, aged 21-51 > > years, including > > healthy subjects (group I, n=30), > > and patients with > > non-erosive gastroduodenal reflux (NERD, group II, n=24), > > with gastroesophageal reflux disease (GERD, group III, n=25), > > with functional dyspepsia (FD, according to the Rome III Criteria, > > group IV, n=36) and with recurrent duodenal ulcer (DUD, group V, > > n=34). Diagnoses were established on the basis of endoscopic imaging > > and histological examination, 24-hour pH-metry and laboratory tests. > > Melatonin serum concentration was measured > > with ELISA method. Blood samples were taken for examination in red- > > lighted room at 10 p.m. and on the following day at 2 and 6 a.m. The > > highest concentration of melatonin in all examined groups was > > determined at 2 a.m. The average melatonin concentration in healthy > > subjects was 34,7 +/- 4,8 pg/ml. In patients with GERD > > and DUD melatonin concentration was lower than in > > healthy subjects - 27,2 +/- 8,5 pg/ml and 25,5 +/- 6,2 pg/ml > > respectively (p < 0,05; p < 0,01). > > The highest concentration of melatonin was found in patients with NERD > > and FD - 43,2 +/- 10,8 pg/ml and > > 42,4 +/- 10,1 pg/ml (p < 0,01; p < 0,05). > > The findings of this study > > support the notion that melatonin exerts beneficial influences on the > > upper digestive tract. It is likely that high or relatively correct > > secretion of melatonin is sufficient to prevent peptic changes in > > esophageal and duodenal > > mucosa. > > > PMID: 17218759 Most nights. I take either 3 or 6 milligrams. I mainly take the brand sold at Costco. It improves my sleep. I tend to have sleep wake pattern that tends to free run and it doesn't matter what I do. The only thing that might prevent it sleeping out of doors and working very hard during the day. I started it in hopes of holding to a "normal sleep pattern", in that it failed. Still once it is time to go to sleep whatever that is according to my body, it improves depth of sleep and tends to prevent insomnia. I still occassional have insomnia especially if I am trying to practice "good sleep hygiene." I've been doing this for some years now and have forgotten when I started on a regular basis. Does it help prevent my GERD? I do not know.
From: Mark on 7 Dec 2007 03:33 On Nov 27, 1:28 am, trigonometry1...(a)gmail.com wrote: > This is something interesting, I've been taking it on a regular > basis for at least several years. I wonder if it > played a role in my getting better with all the > other stuff I do? > ----------------------------- > > J Physiol Pharmacol. 2006 Nov;57 Suppl 5:41-50. > > Nocturnal secretion of melatonin in patients with upper digestive > tract > disorders. > > KlupiÅska G, WiÅniewska-JarosiÅska M, Harasiuk A, > Chojnacki C, Stec-Michalska K, > BÅ,asiak J, Reiter RJ, Chojnacki J. > > Department of Gastroenterology and Internal Diseases, Medical > University of Lodz, 1 Haller's Square, > 90-647 Lodz, Poland. > gas...(a)achilles.wam.lodz.pl. > > Recently, the results of many experimental investigations have > shown that melatonin possesses gastroprotective properties. > On the other hand its role in pathogenesis of upper digestive tract > diseases in man still remains unclear. The aim of the study was to > investigate nocturnal secretion of melatonin in patients > with functional and organic diseases of the upper part of digestive > tract. The investigations were carried out in 149 persons, aged 21-51 > years, including > healthy subjects (group I, n=30), > and patients with > non-erosive gastroduodenal reflux (NERD, group II, n=24), > with gastroesophageal reflux disease (GERD, group III, n=25), > with functional dyspepsia (FD, according to the Rome III Criteria, > group IV, n=36) and with recurrent duodenal ulcer (DUD, group V, > n=34). Diagnoses were established on the basis of endoscopic imaging > and histological examination, 24-hour pH-metry and laboratory tests. > Melatonin serum concentration was measured > with ELISA method. Blood samples were taken for examination in red- > lighted room at 10 p.m. and on the following day at 2 and 6 a.m. The > highest concentration of melatonin in all examined groups was > determined at 2 a.m. The average melatonin concentration in healthy > subjects was 34,7 +/- 4,8 pg/ml. In patients with GERD > and DUD melatonin concentration was lower than in > healthy subjects - 27,2 +/- 8,5 pg/ml and 25,5 +/- 6,2 pg/ml > respectively (p < 0,05; p < 0,01). > The highest concentration of melatonin was found in patients with NERD > and FD - 43,2 +/- 10,8 pg/ml and > 42,4 +/- 10,1 pg/ml (p < 0,01; p < 0,05). > The findings of this study > support the notion that melatonin exerts beneficial influences on the > upper digestive tract. It is likely that high or relatively correct > secretion of melatonin is sufficient to prevent peptic changes in > esophageal and duodenal > mucosa. > > PMID: 17218759 Very interesting. Wikipedia has some interesting info on melatonin also. http://en.wikipedia.org/wiki/Melatonin
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