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From: Matti Narkia on 11 Jul 2008 11:37
Earlier it's have been shown that strontium ranelate (Protelos(R))
improves bone mineral density (BMD) and reduces the risk of vertebral
fracture in women with postmenopausal osteoporosis even when they
already take calcium and vitamin D, see for example the clinical
trial report

Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD,
Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK,
Reginster JY.
The effects of strontium ranelate on the risk of vertebral fracture
in women with postmenopausal osteoporosis.
N Engl J Med. 2004 Jan 29;350(5):459-68.
PMID: 14749454
<http://content.nejm.org/cgi/content/full/350/5/459>

(comments in

Strontium for osteoporosis - Medscape Nov 26, 2004
<http://www.medscape.com/viewarticle/538026>

(may require a free registration)

and

Strontium: A Better Drug for Osteoporosis? - Dr. Weil
<http://www.webcitation.org/5ZEU9NBv4> )

and

the review article

Compston J.
Prevention of vertebral fractures by strontium ranelate in
postmenopausal women with osteoporosis.
Osteoporos Int. 2005 Jan;16 Suppl 1:S4-6. Review.
PMID: 15480571
<http://www.springerlink.com/content/dxkjafu9rlfyb6b2/>


Now the new five-year clinical trial

Reginster JY, Felsenberg D, Boonen S, Diez-Perez A, Rizzoli R, Brandi
ML, Spector TD, Brixen K, Goemaere S, Cormier C, Balogh A, Delmas PD,
Meunier PJ.
Effects of long-term strontium ranelate treatment on the risk of
nonvertebral and vertebral fractures in postmenopausal osteoporosis:
Results of a five-year, randomized, placebo-controlled trial.
Arthritis Rheum. 2008 Jun;58(6):1687-95.
PMID: 18512789
doi: 10.1002/art.23461
<http://www3.interscience.wiley.com/cgi-bin/fulltext/119755350/HTMLSTART>

has shown that strontium ranelate also reduces the risk of hip
fracture and nonvertebral fractures in general. This study is
commented in

Protelos(R) (strontium Ranelate) Is The First Osteoporosis Treatment To
Demonstrate Long-term Reduced Risk Of Hip Fracture
<http://www.medicalnewstoday.com/articles/114599.php>

I live in Europe, so I don't know what's the current status of
strontium ranelate in USA, but to my knowledge at least still fairly
recently it hadn't been approved by FDA. Therefore many osteoporosis
patients in USA have been using strontium dietary supplements such as
strontium citrate, strontium carbonate, strontium chloride, strontium
lactate, and strontium gluconate.

In addition to strontium, vitamin D and calcium, also vitamin K,
magnesium, boron, weight-bearing exercises (jumping for example), and
reducing diet acid load by eating more alkali-producing foods, such as
most vegetables and fruits may be useful in the prevention and
treatment of osteoporosis.


Strontium and osteoporosis links in the group Nutrition of the social
bookmarking site ma.gnolia:

<http://ma.gnolia.com/groups/Nutrition/tags/osteoporosis,strontium?rating=0>
<http://ma.gnolia.com/groups/Nutrition/tags/osteoporosis?rating=0>
<http://ma.gnolia.com/groups/Nutrition/tags/bone?rating=0>

Links related to acid-base balance:

<http://ma.gnolia.com/groups/Nutrition/tags/acid-base?rating=0>


These links may or may not require a free registration at the ma.gnolia
home page

<http://ma.gnolia.com>

If you wish, you can also join group Nutrition: from the menu in the
top of ma.gnolia home page: Find Groups -> enter Nutrition -> GO ->
click the group Nutrition among the offered groups -> JOIN GROUP.
Nutrition group is a public group, so all the members can also post
their own bookmarks.


--
Matti Narkia

http://ma.gnolia.com/groups/Nutrition



From: Matti Narkia on 11 Jul 2008 11:43
Matti Narkia wrote:
> Earlier it's have been shown that strontium ranelate (Protelos(R))
> improves bone mineral density (BMD) and reduces the risk of vertebral
> fracture in women with postmenopausal osteoporosis even when they
> already take calcium and vitamin D, see for example the clinical
> trial report
>
> Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD,
> Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK,
> Reginster JY.
> The effects of strontium ranelate on the risk of vertebral fracture
> in women with postmenopausal osteoporosis.
> N Engl J Med. 2004 Jan 29;350(5):459-68.
> PMID: 14749454
> <http://content.nejm.org/cgi/content/full/350/5/459>
>
> (comments in
>
> Strontium for osteoporosis - Medscape Nov 26, 2004
> <http://www.medscape.com/viewarticle/538026>
>
> (may require a free registration)
>
> and
>
> Strontium: A Better Drug for Osteoporosis? - Dr. Weil
> <http://www.webcitation.org/5ZEU9NBv4> )
>
> and
>
> the review article
>
> Compston J.
> Prevention of vertebral fractures by strontium ranelate in
> postmenopausal women with osteoporosis.
> Osteoporos Int. 2005 Jan;16 Suppl 1:S4-6. Review.
> PMID: 15480571
> <http://www.springerlink.com/content/dxkjafu9rlfyb6b2/>
>
>
> Now the new five-year clinical trial
>
> Reginster JY, Felsenberg D, Boonen S, Diez-Perez A, Rizzoli R, Brandi
> ML, Spector TD, Brixen K, Goemaere S, Cormier C, Balogh A, Delmas PD,
> Meunier PJ.
> Effects of long-term strontium ranelate treatment on the risk of
> nonvertebral and vertebral fractures in postmenopausal osteoporosis:
> Results of a five-year, randomized, placebo-controlled trial.
> Arthritis Rheum. 2008 Jun;58(6):1687-95.
> PMID: 18512789
> doi: 10.1002/art.23461
> <http://www3.interscience.wiley.com/cgi-bin/fulltext/119755350/HTMLSTART>
>
> has shown that strontium ranelate also reduces the risk of hip
> fracture and nonvertebral fractures in general. This study is
> commented in
>
> Protelos(R) (strontium Ranelate) Is The First Osteoporosis Treatment To
> Demonstrate Long-term Reduced Risk Of Hip Fracture
> <http://www.medicalnewstoday.com/articles/114599.php>
>
> I live in Europe, so I don't know what's the current status of
> strontium ranelate in USA, but to my knowledge at least still fairly
> recently it hadn't been approved by FDA. Therefore many osteoporosis
> patients in USA have been using strontium dietary supplements such as
> strontium citrate, strontium carbonate, strontium chloride, strontium
> lactate, and strontium gluconate.
>
> In addition to strontium, vitamin D and calcium, also vitamin K,
> magnesium, boron, weight-bearing exercises (jumping for example), and
> reducing diet acid load by eating more alkali-producing foods, such as
> most vegetables and fruits may be useful in the prevention and
> treatment of osteoporosis.
>
Omega-3 fatty acids and some B-vitamins may also be useful, see the
osteoporosis links in the group Nutrition of the social bookmarking
site ma.gnolia.
>
> Strontium and osteoporosis links in the group Nutrition of the social
> bookmarking site ma.gnolia:
>
> <http://ma.gnolia.com/groups/Nutrition/tags/osteoporosis,strontium?rating=0>
>
> <http://ma.gnolia.com/groups/Nutrition/tags/osteoporosis?rating=0>
> <http://ma.gnolia.com/groups/Nutrition/tags/bone?rating=0>
>
> Links related to acid-base balance:
>
> <http://ma.gnolia.com/groups/Nutrition/tags/acid-base?rating=0>
>
>
> These links may or may not require a free registration at the ma.gnolia
> home page
>
> <http://ma.gnolia.com>
>
> If you wish, you can also join group Nutrition: from the menu in the
> top of ma.gnolia home page: Find Groups -> enter Nutrition -> GO ->
> click the group Nutrition among the offered groups -> JOIN GROUP.
> Nutrition group is a public group, so all the members can also post
> their own bookmarks.
>
--
Matti Narkia

http://ma.gnolia.com/groups/Nutrition
From: Pam on 12 Jul 2008 23:59
Hi Matti: Thanks for the info... SR still isn't available in the U.S., but
Strontium Malonate is in clinical trials and hopefully will be approved.

Pam

"Matti Narkia" <mna(a)mbnet.fi> wrote in message
news:2dLdk.31222$_03.16798(a)reader1.news.saunalahti.fi...
> Matti Narkia wrote:
>> Earlier it's have been shown that strontium ranelate (Protelos(R))
>> improves bone mineral density (BMD) and reduces the risk of vertebral
>> fracture in women with postmenopausal osteoporosis even when they
>> already take calcium and vitamin D, see for example the clinical
>> trial report
>>
>> Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD,
>> Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK,
>> Reginster JY.
>> The effects of strontium ranelate on the risk of vertebral fracture
>> in women with postmenopausal osteoporosis.
>> N Engl J Med. 2004 Jan 29;350(5):459-68.
>> PMID: 14749454
>> <http://content.nejm.org/cgi/content/full/350/5/459>
>>
>> (comments in
>>
>> Strontium for osteoporosis - Medscape Nov 26, 2004
>> <http://www.medscape.com/viewarticle/538026>
>>
>> (may require a free registration)
>>
>> and
>>
>> Strontium: A Better Drug for Osteoporosis? - Dr. Weil
>> <http://www.webcitation.org/5ZEU9NBv4> )
>>
>> and
>>
>> the review article
>>
>> Compston J.
>> Prevention of vertebral fractures by strontium ranelate in
>> postmenopausal women with osteoporosis.
>> Osteoporos Int. 2005 Jan;16 Suppl 1:S4-6. Review.
>> PMID: 15480571
>> <http://www.springerlink.com/content/dxkjafu9rlfyb6b2/>
>>
>>
>> Now the new five-year clinical trial
>>
>> Reginster JY, Felsenberg D, Boonen S, Diez-Perez A, Rizzoli R, Brandi
>> ML, Spector TD, Brixen K, Goemaere S, Cormier C, Balogh A, Delmas PD,
>> Meunier PJ.
>> Effects of long-term strontium ranelate treatment on the risk of
>> nonvertebral and vertebral fractures in postmenopausal osteoporosis:
>> Results of a five-year, randomized, placebo-controlled trial.
>> Arthritis Rheum. 2008 Jun;58(6):1687-95.
>> PMID: 18512789
>> doi: 10.1002/art.23461
>> <http://www3.interscience.wiley.com/cgi-bin/fulltext/119755350/HTMLSTART>
>>
>> has shown that strontium ranelate also reduces the risk of hip
>> fracture and nonvertebral fractures in general. This study is
>> commented in
>>
>> Protelos(R) (strontium Ranelate) Is The First Osteoporosis Treatment To
>> Demonstrate Long-term Reduced Risk Of Hip Fracture
>> <http://www.medicalnewstoday.com/articles/114599.php>
>>
>> I live in Europe, so I don't know what's the current status of
>> strontium ranelate in USA, but to my knowledge at least still fairly
>> recently it hadn't been approved by FDA. Therefore many osteoporosis
>> patients in USA have been using strontium dietary supplements such as
>> strontium citrate, strontium carbonate, strontium chloride, strontium
>> lactate, and strontium gluconate.
>>
>> In addition to strontium, vitamin D and calcium, also vitamin K,
>> magnesium, boron, weight-bearing exercises (jumping for example), and
>> reducing diet acid load by eating more alkali-producing foods, such as
>> most vegetables and fruits may be useful in the prevention and
>> treatment of osteoporosis.
>>
> Omega-3 fatty acids and some B-vitamins may also be useful, see the
> osteoporosis links in the group Nutrition of the social bookmarking
> site ma.gnolia.
>>
>> Strontium and osteoporosis links in the group Nutrition of the social
>> bookmarking site ma.gnolia:
>>
>> <http://ma.gnolia.com/groups/Nutrition/tags/osteoporosis,strontium?rating=0>
>> <http://ma.gnolia.com/groups/Nutrition/tags/osteoporosis?rating=0>
>> <http://ma.gnolia.com/groups/Nutrition/tags/bone?rating=0>
>>
>> Links related to acid-base balance:
>>
>> <http://ma.gnolia.com/groups/Nutrition/tags/acid-base?rating=0>
>>
>>
>> These links may or may not require a free registration at the ma.gnolia
>> home page
>>
>> <http://ma.gnolia.com>
>>
>> If you wish, you can also join group Nutrition: from the menu in the
>> top of ma.gnolia home page: Find Groups -> enter Nutrition -> GO ->
>> click the group Nutrition among the offered groups -> JOIN GROUP.
>> Nutrition group is a public group, so all the members can also post
>> their own bookmarks.
>>
> --
> Matti Narkia
>
> http://ma.gnolia.com/groups/Nutrition
>



From: trigonometry1972 on 13 Jul 2008 05:03
On Jul 12, 8:59 pm, "Pam" <phflores~nosp...(a)verizon.net> wrote:
> Hi Matti:  Thanks for the info...  SR still isn't available in the U.S., but
> Strontium Malonate is in clinical trials and hopefully will be approved.
>
> Pam
>
> "Matti Narkia" <m...(a)mbnet.fi> wrote in message
>
> news:2dLdk.31222$_03.16798(a)reader1.news.saunalahti.fi...
>
>
>
> > Matti Narkia wrote:
> >> Earlier it's have been shown that strontium ranelate (Protelos(R))
> >> improves bone mineral density (BMD) and reduces the risk of vertebral
> >> fracture in women with postmenopausal osteoporosis even when they
> >> already take calcium and vitamin D, see for example the clinical
> >> trial report
>
> >> Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD,
> >> Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK,
> >> Reginster JY.
> >> The effects of strontium ranelate on the risk of vertebral fracture
> >> in women with postmenopausal osteoporosis.
> >> N Engl J Med. 2004 Jan 29;350(5):459-68.
> >> PMID: 14749454
> >> <http://content.nejm.org/cgi/content/full/350/5/459>
>
> >> (comments in
>
> >> Strontium for osteoporosis - Medscape Nov 26, 2004
> >> <http://www.medscape.com/viewarticle/538026>
>
> >> (may require a free registration)
>
> >> and
>
> >> Strontium: A Better Drug for Osteoporosis? - Dr. Weil
> >> <http://www.webcitation.org/5ZEU9NBv4> )
>
> >> and
>
> >> the review article
>
> >> Compston J.
> >> Prevention of vertebral fractures by strontium ranelate in
> >> postmenopausal women with osteoporosis.
> >> Osteoporos Int. 2005 Jan;16 Suppl 1:S4-6. Review.
> >> PMID: 15480571
> >> <http://www.springerlink.com/content/dxkjafu9rlfyb6b2/>
>
> >> Now the new five-year clinical trial
>
> >> Reginster JY, Felsenberg D, Boonen S, Diez-Perez A, Rizzoli R, Brandi
> >> ML, Spector TD, Brixen K, Goemaere S, Cormier C, Balogh A, Delmas PD,
> >> Meunier PJ.
> >> Effects of long-term strontium ranelate treatment on the risk of
> >> nonvertebral and vertebral fractures in postmenopausal osteoporosis:
> >> Results of a five-year, randomized, placebo-controlled trial.
> >> Arthritis Rheum. 2008 Jun;58(6):1687-95.
> >> PMID: 18512789
> >> doi: 10.1002/art.23461
> >> <http://www3.interscience.wiley.com/cgi-bin/fulltext/119755350/HTMLSTART>
>
> >> has shown that strontium ranelate also reduces the risk of hip
> >> fracture and nonvertebral fractures in general. This study is
> >> commented in
>
> >> Protelos(R) (strontium Ranelate) Is The First Osteoporosis Treatment To
> >> Demonstrate Long-term Reduced Risk Of Hip Fracture
> >> <http://www.medicalnewstoday.com/articles/114599.php>
>
> >> I live in Europe, so I don't know what's the current status of
> >> strontium ranelate in USA, but to my knowledge at least still fairly
> >> recently it hadn't been approved by FDA. Therefore many osteoporosis
> >> patients in USA have been using strontium dietary supplements such as
> >> strontium citrate, strontium carbonate, strontium chloride, strontium
> >> lactate, and strontium gluconate.
>
> >> In addition to strontium, vitamin D and calcium, also vitamin K,
> >> magnesium, boron, weight-bearing exercises (jumping for example), and
> >> reducing diet acid load by eating more alkali-producing foods, such as
> >> most vegetables and fruits may be useful in the prevention and
> >> treatment of osteoporosis.
>
> > Omega-3 fatty acids and some B-vitamins may also be useful, see the
> > osteoporosis links in the group Nutrition of the social bookmarking
> > site  ma.gnolia.
>
> >> Strontium and osteoporosis links in the group Nutrition of the social
> >> bookmarking site ma.gnolia:
>
> >> <http://ma.gnolia.com/groups/Nutrition/tags/osteoporosis,strontium?rat....>
> >> <http://ma.gnolia.com/groups/Nutrition/tags/osteoporosis?rating=0>
> >> <http://ma.gnolia.com/groups/Nutrition/tags/bone?rating=0>
>
> >> Links related to acid-base balance:
>
> >> <http://ma.gnolia.com/groups/Nutrition/tags/acid-base?rating=0>
>
> >> These links may or may not require a free registration at the ma.gnolia
> >> home page
>
> >> <http://ma.gnolia.com>
>
> >> If you wish, you can also join group Nutrition: from the menu in the
> >> top of ma.gnolia home page: Find Groups -> enter Nutrition -> GO ->
> >> click the group Nutrition among the offered groups -> JOIN GROUP.
> >> Nutrition group is a public group, so all the members can also post
> >> their own bookmarks.
>
> > --
> > Matti Narkia
>
> >http://ma.gnolia.com/groups/Nutrition

Yes clearly the working end of things is the strontium and not
whatever the specific drug company chooses to use as
to form a organic salt with Sr. Indeed, the malonic acid
is native both to our biochemistry and is also found
in some foods. And clearly if malonate is good and
there is every reason to know this is true then the succinate
form can't be far behind.

In a slightly more ideal world the ranelate form would never
be approved in the States given the behavior of its owners.

From: Matti Narkia on 13 Jul 2008 07:21
Pam wrote:

> Hi Matti: Thanks for the info... SR still isn't available in the U.S., but
> Strontium Malonate is in clinical trials and hopefully will be approved.
>
Thanks for the info, Pam. I found this link

A Dose-Response Study With Strontium Malonate in Postmenopausal Women
<http://clinicaltrials.gov/ct2/show/NCT00409032

for a phase II trial, where different doses of strontium malonate were
compared to strontium ranelate (Protelos(R)) and placebo. It seems
that Osteologix has already issued a press release about the results
of this trial:

Osteologix Presents Phase 2 Osteoporosis Data at a Major European
Medical Conference
<http://www.osteologix.com/wb0005.php?oid=5>

A citation (NB S101 is strontium malonate):

"� All three doses of NB S101 (0.75g, 1.0g, 2.0g) were safe and
well tolerated with the frequency and types of adverse events
comparable to those with the active comparator, Protelos�
(strontium ranelate).

� Bone resorption assessed with the CTX-1 marker indicated a
dose-dependent effect of NB S101 to reduce bone resorption

� All three doses of NB S101 achieved statistically significant
reductions in CTX-1, with the 2 gram dose of NB S101 achieving
significantly greater reductions of CTX-1 (p<0.001) than the 2
gram dose of Protelos�(strontium ranelate).

� All three doses of NB S101 significantly increased BMD as
measured at the total hip and lumbar spine."

And here is a just published Danish animal study about strontium
malonate:

Raffalt AC, Andersen JE, Christgau S.
Application of inductively coupled plasma-mass spectrometry (ICP-MS)
and quality assurance to study the incorporation of strontium into
bone, bone marrow, and teeth of dogs after one month of treatment with
strontium malonate.
Anal Bioanal Chem. 2008 Jul;391(6):2199-207. Epub 2008 May 23.
PMID: 18496676
<http://www.springerlink.com/content/625423xj274g0822/>


--
Matti Narkia

http://ma.gnolia.com/groups/Nutrition


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