Neurodegenerative Iron Spots
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From: ironjustice on 10 Aug 2008 09:41 Alzheimer Disease Plaques Seen with Conventional MRI in Animal Model for the First Time - MRI and advanced computer analysis bring us closer to early identification of Alzheimer's - Chicago, July 27, 2008 – For the first time, scientists have captured images of brain lesions similar to those found in Alzheimer's disease using clinical-grade MRI in an animal model of the disease, according to research reported today at the Alzheimer's Association's 2008 International Conference on Alzheimer's Disease (ICAD 2008), in Chicago. These lesions, known as amyloid plaques, have been "imaged" previously using very high power MRI scanners that are only used on animals, and also with PET scans combined with specialized marker chemicals. This is the first time images of plaques were captured with conventional, clinical strength MRI. John Ronald, a Ph.D. candidate in Medical Biophysics, along with Brian Rutt, PhD, and colleagues at the Robarts Research Institute and University of Western Ontario, London, Ontario, Canada, used clinical strength MRI scanners to take brain images from rabbits that had been fed a high cholesterol diet for more than two years. These animals form amyloid plaques in their brains. According to the researchers, the MRI scans revealed distinct signal voids – black spots – in several brain areas including the hippocampus, which is very important for memory. Autopsy examination revealed that the void areas reflected the presence of small clusters of amyloid plaques. Each cluster had high levels of iron, which the researchers say caused the MRI signal voids; these signal voids were not found in animals fed a normal diet. http://www.alz.org/icad/_icad_release_072708_3pm_mri.asp ----------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
From: jay on 11 Aug 2008 00:04 > ... rabbits that had been fed a high cholesterol diet for more > than two years. These animals form amyloid plaques in their brains. 7-Ketocholesterol is one of the major forms of oxidized cholesterol found in vivo. While 7-Ketocholesterol activates AhR-mediated pathways, Persistent Organic Pollutants (ie TCDD, a potent dioxin) are even stronger activators. 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor. We have identified 7-ketocholesterol (7-KC) as an endogenous modulator that inhibits transactivation by the arylhydrocarbon receptor (AhR) through competitive binding against xenobiotic ligands. 7-KC binds AhR and displaces labeled dioxin (2,3,7,8-tetrachlorodibenzo(p)dioxin (TCDD)). IC(50) is 5 x 10(-7) m in vivo and 7 x 10(-6) m in vitro. These figures are consistent with its concentration in human blood plasma and tissues. Association with 7-KC prevents AhR binding to DNA. 7-KC blocks the TCDD-mediated transactivation of stably expressed reporter gene constructs in T47-D cells as well as the expression of the endogenous CYP 1A1 gene in HepG2 cells and in primary porcine aortic endothelial cells. Injection of 7-KC to rats blocks the induction of CYP 1A1 messenger RNA and protein in endothelial cells from myocardial blood vessels. The differential sensitivity of mammalian species to toxic effects of AhR ligands, especially dioxin (TCDD), correlates with the expression of 7-hydroxycholesterol dehydrogenase, which synthesizes 7-KC from 7-hydroxycholesterol. The documented involvement of AhR ligands in cardiovascular diseases through lipid peroxidation and endothelium dysfunction can now be examined in the context of displacement of this protective modulator. PMID: 11042205
From: ironjustice on 11 Aug 2008 00:50 On Aug 10, 9:04Â pm, jay <jaym1...(a)hotmail.com> wrote: snip << I see you didn't mention anything about iron .. How about the Middle Ages .. there .. buddy .. ------------------- Each cluster had high levels of iron, which the researchers say caused the MRI signal voids; these signal voids were not found in animals fed a normal diet. http://www.alz.org/icad/_icad_release_072708_3pm_mri.asp ----------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/4rq595 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > > ... rabbits that had been fed a high cholesterol diet for more > > than two years. These animals form amyloid plaques in their brains. > > 7-Ketocholesterol is one of the major forms of oxidized cholesterol > found in vivo. While 7-Ketocholesterol activates AhR-mediated > pathways, Persistent Organic Pollutants (ie TCDD, a potent dioxin) are > even stronger activators. > > 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon > receptor. > We have identified 7-ketocholesterol (7-KC) as an endogenous modulator > that inhibits transactivation by the arylhydrocarbon receptor (AhR) > through competitive binding against xenobiotic ligands. 7-KC binds AhR > and displaces labeled dioxin (2,3,7,8-tetrachlorodibenzo(p)dioxin > (TCDD)). IC(50) is 5 x 10(-7) m in vivo and 7 x 10(-6) m in vitro. > These figures are consistent with its concentration in human blood > plasma and tissues. Association with 7-KC prevents AhR binding to DNA. > 7-KC blocks the TCDD-mediated transactivation of stably expressed > reporter gene constructs in T47-D cells as well as the expression of > the endogenous CYP 1A1 gene in HepG2 cells and in primary porcine > aortic endothelial cells. Injection of 7-KC to rats blocks the > induction of CYP 1A1 messenger RNA and protein in endothelial cells > from myocardial blood vessels. The differential sensitivity of > mammalian species to toxic effects of AhR ligands, especially dioxin > (TCDD), correlates with the expression of 7-hydroxycholesterol > dehydrogenase, which synthesizes 7-KC from 7-hydroxycholesterol. The > documented involvement of AhR ligands in cardiovascular diseases > through lipid peroxidation and endothelium dysfunction can now be > examined in the context of displacement of this protective modulator. > PMID: 11042205
From: jay on 11 Aug 2008 01:32 > > While 7-Ketocholesterol activates AhR-mediated > > pathways, Persistent Organic Pollutants (ie TCDD, > > a potent dioxin) are even stronger activators. > > How about the Middle Ages .. there .. buddy .. The Ah-R mediated pathways are also activated by compounds generated by combustion of matter found in Middle Ages and before. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. The mammalian CYP1A1, CYP1A2, and CYP1B1 genes (encoding cytochromes P450 1A1, 1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR). The CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion products... PMID: 15028720 Wiki - PAHs: Natural crude oil and coal deposits contain significant amounts of PAHs, arising from chemical conversion of natural product molecules, such as steroids, to aromatic hydrocarbons. Formed by incomplete combustion of carbon-containing fuels such as wood, coal, diesel, fat, tobacco, or incense. Wiki - Some heterocyclic amines (HCAs) found in cooked meat are known carcinogens. Research has shown that cooking certain meats at high temperatures creates chemicals that are not present in uncooked meats. For example, heterocyclic amines are the carcinogenic chemicals formed from the cooking of muscle meats such as beef, pork, fowl, and fish. HCAs form when amino acids and creatine (a chemical found in muscles) react at high cooking temperatures. Researchers have identified 17 different HCAs resulting from the cooking of muscle meats that may pose human cancer risk. NCI's Division of Cancer Epidemiology and Genetics found a link between individuals with stomach cancer and the consumption of cooked meat, and other studies for colorectal, pancreatic, and breast cancer is associated with high intakes of well- done, fried, or barbecued meats.
From: jay on 11 Aug 2008 01:37
> I see you didn't mention anything about iron .. Activation of Aryl Hydrocarbon Receptor Mediated Pathways increases cellular production of iron-utilizing detoxification enzymes (CYP1A1, CPY1A2, CYP1B, etc). |