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From: ironjustice on 6 Aug 2008 10:57
"Iron-chelating and free-radical scavenging green tea extract"

Effect of green tea on iron status and oxidative stress in iron-loaded
rats.
Med Chem. 2008 Jul;4(4):365-70.
Ounjaijean S, Thephinlap C, Khansuwan U, Phisalapong C, Fucharoen S,
Porter JB, Srichairatanakool S.
Department of Biochemistry, Faculty of Medicine, Chiang Mai
University, Chiang Mai 50200, Thailand. ssrichai(a)mail.ed.cmu.ac.th.

Plasma non-transferrin bound iron (NTBI) is potentially toxic and
contributes to the generation of reactive oxygen species (ROS),
consequently leading to tissue damage and organ dysfunction.
Iron chelators and antioxidants are used for treatment of thalassemia
patients. Green tea (GT) contains catechins derivatives that have many
biological activities. The purpose of this study was to investigate
the iron-chelating and free-radical scavenging capacities of green tea
extract in vivo. Rats were injected ip with ferric citrate together
with orally administered GT extract (GTE) for 4 months. Blood was
collected monthly for measurement of iron overload and oxidative
stress indicators. Plasma iron (PI) and total iron-binding capacity
(TIBC) were quantified using bathophenanthroline method. Plasma NTBI
was assayed with NTA chelation/HPLC. Plasma malonyldialdehyde (MDA)
was determined by using the TBARS method. Erythrocyte oxidative stress
was assessed using flow cytometry. Levels of PI, TIBC, NTBI and MDA,
and erythrocyte ROS increased in the iron-loaded rats. Intervention
with GT extract markedly decreased the PI and TIBC concentrations. It
also lowered the transferrin saturation and effectively inhibited
formation of NTBI. It also decreased the levels of erythrocyte ROS in
week 4, 12 and 16. Therefore, green tea extract can decrease iron in
plasma as well as eliminate lipid peroxidation in plasma, and destroy
formation of erythrocyte ROS in the rats challenged with iron. The
bifunctional effects could be beneficial in alleviating the iron and
oxidative stress toxicity. In prospective, these GTE activities should
be further examined in thalassemic animals or humans.

PMID: 18673149


Who loves ya.
Tom


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From: timmythesaint on 7 Aug 2008 03:22
Didn't Jesus eat fish? I think I remember somethimg about that from my
scholing. Or is fish not meat in the eyes of a vegatrian?
Tim
From: Andrew Heenan on 7 Aug 2008 04:46
"timmythesaint" <timwardman(a)hotmail.com> wrote ...
> Didn't Jesus eat fish? I think I remember somethimg about that from my
> scholing. Or is fish not meat in the eyes of a vegatrian?

Fish *is* meat in the eyes of a vegetarian,
But fish is NOT meat in the eyes of a vegatrian. It's a bicycle.

--
Andrew

"Why do all the insane people cross post all over Usenet?"

;o)


From: RF on 7 Aug 2008 13:39
OK, Expert Tom,

Bravo for the green tea extract but how
concentrated is it? - how many regular green tea
bags would it take to get the "extract dose"?

Do I need to hike to Thailand to find out? If I
have to, I'll talk to those guys and teach them
how to write ;-)


ironjustice(a)aol.com wrote:
> "Iron-chelating and free-radical scavenging green tea extract"
>
> Effect of green tea on iron status and oxidative stress in iron-loaded
> rats.
> Med Chem. 2008 Jul;4(4):365-70.
> Ounjaijean S, Thephinlap C, Khansuwan U, Phisalapong C, Fucharoen S,
> Porter JB, Srichairatanakool S.
> Department of Biochemistry, Faculty of Medicine, Chiang Mai
> University, Chiang Mai 50200, Thailand. ssrichai(a)mail.ed.cmu.ac.th.
>
> Plasma non-transferrin bound iron (NTBI) is potentially toxic and
> contributes to the generation of reactive oxygen species (ROS),
> consequently leading to tissue damage and organ dysfunction.
> Iron chelators and antioxidants are used for treatment of thalassemia
> patients. Green tea (GT) contains catechins derivatives that have many
> biological activities. The purpose of this study was to investigate
> the iron-chelating and free-radical scavenging capacities of green tea
> extract in vivo. Rats were injected ip with ferric citrate together
> with orally administered GT extract (GTE) for 4 months. Blood was
> collected monthly for measurement of iron overload and oxidative
> stress indicators. Plasma iron (PI) and total iron-binding capacity
> (TIBC) were quantified using bathophenanthroline method. Plasma NTBI
> was assayed with NTA chelation/HPLC. Plasma malonyldialdehyde (MDA)
> was determined by using the TBARS method. Erythrocyte oxidative stress
> was assessed using flow cytometry. Levels of PI, TIBC, NTBI and MDA,
> and erythrocyte ROS increased in the iron-loaded rats. Intervention
> with GT extract markedly decreased the PI and TIBC concentrations. It
> also lowered the transferrin saturation and effectively inhibited
> formation of NTBI. It also decreased the levels of erythrocyte ROS in
> week 4, 12 and 16. Therefore, green tea extract can decrease iron in
> plasma as well as eliminate lipid peroxidation in plasma, and destroy
> formation of erythrocyte ROS in the rats challenged with iron. The
> bifunctional effects could be beneficial in alleviating the iron and
> oxidative stress toxicity. In prospective, these GTE activities should
> be further examined in thalassemic animals or humans.
>
> PMID: 18673149
>
>
> Who loves ya.
> Tom
From: RF on 7 Aug 2008 23:50
Andrew Heenan wrote:
> "timmythesaint" <timwardman(a)hotmail.com> wrote ...
>> Didn't Jesus eat fish? I think I remember somethimg about that from my
>> scholing. Or is fish not meat in the eyes of a vegatrian?
>
> Fish *is* meat in the eyes of a vegetarian,
> But fish is NOT meat in the eyes of a vegatrian. It's a bicycle.

VERRRYYY FUUNNNYYYY! Andrew. Thanks for the laughs :-)


> Andrew
>
> "Why do all the insane people cross post all over Usenet?"
>
> ;o)
>
>
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