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From: ironjustice on 6 Aug 2008 11:02
"Iron-chelating and free-radical scavenging green tea extract"

Effect of green tea on iron status and oxidative stress in iron-loaded
rats.
Med Chem. 2008 Jul;4(4):365-70.
Ounjaijean S, Thephinlap C, Khansuwan U, Phisalapong C, Fucharoen S,
Porter JB, Srichairatanakool S.
Department of Biochemistry, Faculty of Medicine, Chiang Mai
University, Chiang Mai 50200, Thailand. ssrichai(a)mail.ed.cmu.ac.th.

Plasma non-transferrin bound iron (NTBI) is potentially toxic and
contributes to the generation of reactive oxygen species (ROS),
consequently leading to tissue damage and organ dysfunction.
Iron chelators and antioxidants are used for treatment of thalassemia
patients. Green tea (GT) contains catechins derivatives that have many
biological activities. The purpose of this study was to investigate
the iron-chelating and free-radical scavenging capacities of green tea
extract in vivo. Rats were injected ip with ferric citrate together
with orally administered GT extract (GTE) for 4 months. Blood was
collected monthly for measurement of iron overload and oxidative
stress indicators. Plasma iron (PI) and total iron-binding capacity
(TIBC) were quantified using bathophenanthroline method. Plasma NTBI
was assayed with NTA chelation/HPLC. Plasma malonyldialdehyde (MDA)
was determined by using the TBARS method. Erythrocyte oxidative stress
was assessed using flow cytometry. Levels of PI, TIBC, NTBI and MDA,
and erythrocyte ROS increased in the iron-loaded rats. Intervention
with GT extract markedly decreased the PI and TIBC concentrations. It
also lowered the transferrin saturation and effectively inhibited
formation of NTBI. It also decreased the levels of erythrocyte ROS in
week 4, 12 and 16. Therefore, green tea extract can decrease iron in
plasma as well as eliminate lipid peroxidation in plasma, and destroy
formation of erythrocyte ROS in the rats challenged with iron. The
bifunctional effects could be beneficial in alleviating the iron and
oxidative stress toxicity. In prospective, these GTE activities should
be further examined in thalassemic animals or humans.

PMID: 18673149


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